Navigation Links
With record resolution and sensitivity, tool images how life organizes in a cell membrane

I know that this is cholesterol or this is sphingomyelin or this is some other molecule. You need a way to do analytical chemistry, only with extreme sensitivity, because we're not talking about very many molecules.''

The answer is isotopes. The NanoSIMS 50 can detect extremely small differences in mass among molecular fragments labeled with different isotopes. And the machine has five detectors, so scientists can look at five different isotopically labeled molecules at a time. The picture from each isotope is overlaid to produce a composite image that provides rich, mass-specific information about chemically what's in that cell membrane.

Boxer compared the concept to learning about people sitting in chairs in a room to the organization of individual molecules in a membrane. ''If you look at the room, you want to be able to see not just the chair but also what kind of chair it is... and I want to see who is nearby, and that chair over there is empty... I'd like to know that you're sitting in a chair and that that chair is different from that [other] chair. And that's what's been missing. We just don't have analytical tools that give us this combination of sensitivity, analytical information and spatial resolution.''

For the Science study, Boxer and colleagues made a spherical lipid vesicle to model a cell membrane, placed it on a small silicon wafer to make the lipid bilayer flatten into two dimensions and organized the flat membrane with a pattern of chrome grids to provide ''landmarks'' on the surface. That system let the scientists track how lipids moved and measure how many of each type of lipid resided in an area.

''We're looking for lateral organization of some sort believed to be present in membranes,'' Boxer said. ''There is now no really good way to measure it. There's got to be something that makes one part of a cell different from another part of a cell. But the forces that are responsible for segregating components, or co
'"/>

Source:Stanford University


Page: 1 2 3 4 5 6

Related biology news :

1. Space matters: Estimating species diversity in the fossil record
2. Nano springs eternal; Protozoan engine posts nano records
3. Immunization rates hit record high in poor countries
4. New law for resolution allows unprecedented sharpness in fluorescence microscopy
5. High resolution snapshots detail dynamics of a cocaine antibody
6. High-resolution light microscope reveals the fundamental mechanisms of nerve communication
7. Recombination protein dynamics observed with single monomer resolution
8. New MRI technique quickly builds 3-D images of knees
9. Everything in its place: Researchers identify brain cells used to categorize images
10. Novel computed imaging technique uses blurry images to enhance view
11. Ultrasound upgrade produces images that work like 3-D movies
Post Your Comments:
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
(Date:4/2/2015)... Md. , April 2, 2015 At ... Salt Lake City , the American College ... of five new directors to its Board.  Members of ... the ACMG and for forming and advancing its policies ... medical genetics profession. "It,s an eventful time ...
(Date:3/31/2015)...  Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant ... Defined Network Architecture (ET Software DNA® 2.0) platforms and ... $20.4 million for the year ended December 31, 2014 ... year ended December 31, 2013. At ... its multi-year transition away from its legacy landline business ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... manage to efficiently collect a lot of nectar with limited ... queen bee is too busy laying eggs to oversee something ... on any given morning. According to new research from the ... organized bees can also be used to improve the efficiency ...
... developing world, has announced the winners of the TWAS Prizes ... be invited to lecture about his or her research at ... in Mexico City from 10 to 13 November 2008. ... Sciences, University of Agriculture, Faisalabad, Pakistan, has won the 2007 ...
... habitat changes, animals migrate. But how do immobile organisms ... environment? This is an increasingly important question in light ... change. A University of Virginia study, published in ... that plants grown in the same setting as their ...
Cached Biology News:Bee strategy helps servers run more sweetly 2Bee strategy helps servers run more sweetly 3TWAS announces 2007 prize winners 2TWAS announces 2007 prize winners 3TWAS announces 2007 prize winners 4Evolutionary biology research on plant shows significance of maternal effects 2
(Date:5/4/2015)... , May 4, 2015  RegeneRx Biopharmaceuticals, ... announced that an independent team of researchers from ... that Thymosin B4 (TB4) plays an important role ... wounds, induced in an experimental mouse model, by ... remodeling of damaged dermal tissue.  The research found ...
(Date:5/4/2015)... - New Massive Open Online ... for the United States Medical Licensing Examination ... and medical information products and services, announced today that ... Course) designed to help medical students prepare for the ... first and most daunting of the three exams medical ...
(Date:5/1/2015)...  Northwest Biotherapeutics (NASDAQ: NWBO ) ("NW Bio"), ... for solid tumor cancers, announced today that the Company ... a $40 million investment from Woodford investment funds in ... million in NW Bio on November 19, 2014.  On ... the Company for a further $40 million investment in ...
(Date:5/1/2015)... -- A new report by  visiongain  forecasts ... $22.4bn in 2019. That revenue forecast and others appear ... 2015-2025 ,  published in March 2015. ... forecasts and qualitative analyses of the antithrombotic drugs market. ... London, UK . It produces analyses ...
Breaking Biology Technology:Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5
... R.I. [Brown University] Creating catalysts that can operate efficiently ... taking fuel-cell technology from the lab bench to the assembly ... many researchers, but platinum has two major downsides: It is ... In a new study, chemists at Brown University report ...
... New ... ... sustainable farming methods to meet a growing global food demand, and a new online resource from ... they do it. , , ,The new website, which can be found here , will ...
... May 24 /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems Ltd.,(Nasdaq: DHRM ), ... in China , announced today an exclusive distributor,agreement for HEYER Medical,s ... models of this product. , , ... HEYER Cumulus is suitable for the treatment of ...
Cached Biology Technology:Brown chemists report promising advance in fuel-cell technology 2Farmers Use Sustainable Farming Methods to Meet Global Food Demand 2Dehaier Medical Systems Continues Product Line Expansion. Signs Exclusive Distribution Agreement with HEYER Medical for Respiratory Products in China 2Dehaier Medical Systems Continues Product Line Expansion. Signs Exclusive Distribution Agreement with HEYER Medical for Respiratory Products in China 3Dehaier Medical Systems Continues Product Line Expansion. Signs Exclusive Distribution Agreement with HEYER Medical for Respiratory Products in China 4
...
...
... and supplies, for 10 chips, provides ... perform high-sensitivity RNA analysis (picogram levels) ... automated electrophoresis system. Supplied are 1,250 ... HighSens stain, 20 microliters RNA ladder, ...
Anti-NCAPD3 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunoprecipitation, Western Blot...
Biology Products: