Navigation Links
With record resolution and sensitivity, tool images how life organizes in a cell membrane

I know that this is cholesterol or this is sphingomyelin or this is some other molecule. You need a way to do analytical chemistry, only with extreme sensitivity, because we're not talking about very many molecules.''

The answer is isotopes. The NanoSIMS 50 can detect extremely small differences in mass among molecular fragments labeled with different isotopes. And the machine has five detectors, so scientists can look at five different isotopically labeled molecules at a time. The picture from each isotope is overlaid to produce a composite image that provides rich, mass-specific information about chemically what's in that cell membrane.

Boxer compared the concept to learning about people sitting in chairs in a room to the organization of individual molecules in a membrane. ''If you look at the room, you want to be able to see not just the chair but also what kind of chair it is... and I want to see who is nearby, and that chair over there is empty... I'd like to know that you're sitting in a chair and that that chair is different from that [other] chair. And that's what's been missing. We just don't have analytical tools that give us this combination of sensitivity, analytical information and spatial resolution.''

For the Science study, Boxer and colleagues made a spherical lipid vesicle to model a cell membrane, placed it on a small silicon wafer to make the lipid bilayer flatten into two dimensions and organized the flat membrane with a pattern of chrome grids to provide ''landmarks'' on the surface. That system let the scientists track how lipids moved and measure how many of each type of lipid resided in an area.

''We're looking for lateral organization of some sort believed to be present in membranes,'' Boxer said. ''There is now no really good way to measure it. There's got to be something that makes one part of a cell different from another part of a cell. But the forces that are responsible for segregating components, or co
'"/>

Source:Stanford University


Page: 1 2 3 4 5 6

Related biology news :

1. Space matters: Estimating species diversity in the fossil record
2. Nano springs eternal; Protozoan engine posts nano records
3. Immunization rates hit record high in poor countries
4. New law for resolution allows unprecedented sharpness in fluorescence microscopy
5. High resolution snapshots detail dynamics of a cocaine antibody
6. High-resolution light microscope reveals the fundamental mechanisms of nerve communication
7. Recombination protein dynamics observed with single monomer resolution
8. New MRI technique quickly builds 3-D images of knees
9. Everything in its place: Researchers identify brain cells used to categorize images
10. Novel computed imaging technique uses blurry images to enhance view
11. Ultrasound upgrade produces images that work like 3-D movies
Post Your Comments:
(Date:4/17/2014)... In the most densely forested and most densely ... centuries of human needs, values and practices. Disturbances associated ... for agriculture and development, have set the stage for ... Service study reports. , The report Five anthropogenic ... needs in the Northern United States was ...
(Date:4/17/2014)... development of stem cell therapies to cure a variety ... cell populations based on cell surface markers. Researchers from ... that is highly expressed in a type of stem ... describe in an article in BioResearch Open Access ... publishers. The article is available free on the ...
(Date:4/17/2014)... A credit-card-sized anthrax detection cartridge developed at Sandia ... makes testing safer, easier, faster and cheaper. , ... is commonly found in soils all over the world ... both humans and animals. The bacteria can survive in ... B. anthracis may occur through skin contact, inhalation ...
Breaking Biology News(10 mins):Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... in the brain improves recovery from stroke when injected up ... could be used as an effective stroke drug. A study ... Biology shows that an injection of Granulocyte-Colony Stimulating Factor (G-CSF), ... of neurons and counteract neurone death, reduces the size of ...
... disorders that have led to an epidemic of obesity and ... at Penn State University that are due to be published ... the National Academy of Science and also in the PNAS ... The discovery expands the known taxonomic breadth of metabolic ...
... get a lot easier and cheaper thanks to the work ... , Syed Hashsham, an associate professor in the Department of ... is developing a portable, hand-held device capable of detecting up ... , "This device will give us the ability ...
Cached Biology News:Brain protein improves stroke symptoms in rats, even when injected after 3 days 2Dragonfly's metabolic disease provides clues about human obesity 2Dragonfly's metabolic disease provides clues about human obesity 3Dragonfly's metabolic disease provides clues about human obesity 4Dragonfly's metabolic disease provides clues about human obesity 5Professors to develop hand-held pathogen testing device 2
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to announce that ... an e-Journal and producer of Food Labs Conference ... for the co-location of Food Labs Conference to be held ... registration fee to attend the two-day Food Lab Conference, March ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... 1, 2011 Nycomed US Inc. ("Nycomed US") today announced ... Executive Officer and member of the Board for what will ... of the acquisition of Nycomed A/S by Takeda Pharmaceuticals.   ... the newly created position of Chief Operating Officer, and John ...
... signals, for the first time, to assist in braking, ... to the thousands of car accidents that are caused ... technique that attaches electrodes to the scalp , the ... traffic sensors, could detect a driver,s intention to break ...
... Protein Therapeutics Association (PPTA) applauds the introduction of bipartisan ... ( H.R. 2672 ) and ( S. 1423 ), which ... patients with rare diseases by eliminating barriers to innovation. ... therapies are coping with a very rare disease for which ...
Cached Biology Technology:Nycomed US Inc. Names Brian A. Markison as Chief Executive Officer 2Nycomed US Inc. Names Brian A. Markison as Chief Executive Officer 3Put the brakes on using your brain power 2PPTA Praises Legislation That Protects the Treatment of Rare Diseases 2
... 100% capped transcripts with the translation boosting ... of 100% capped (versus 40% to 80% ... in about 2 hours. mScript™ also features ... shown to be up to 50% more ...
Immunogen: Synthetic peptide: M(1) C V P R S G L I L S(11) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Immunogen: Recombinant full length protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Immunogen: Synthetic peptide derived from ... and bovine Math-2. Specificity: Specific ... Human Rat (positive controls: human U251 ... lysates and rat brain homogenates)Storage: Store ...
Biology Products: