Navigation Links
With record resolution and sensitivity, tool images how life organizes in a cell membrane

high sensitivity and high spatial resolution and high chemical information content.''

Boxer's group used atomic force microscopy to locate interesting places and then employed the NanoSIMS 50 to determine what was there chemically. ''Either technique by itself would be I think insufficient, but combined, they're really powerful,'' Boxer said. The combination of techniques allowed the researchers to distinguish debris from features of interest.

''The real point is that you can do quantitative analysis,'' Boxer said, emphasizing that this research allowed the first high-resolution mapping of chemical features in a region of interest. ''We can analyze a few percent of one component in the presence of other components...It's exquisitely sensitive.''

Sensitivity is important because cell membranes are not pure materials. ''We're looking at mixtures of things, and we want to be able to say that we've got one molecule in 20 of type A mixed in with type B, or something like that,'' Boxer said.

This world is flat-sometimes

''Imagine how a cell could divide if it weren't for the fact that the membranes were flexible,'' Boxer said. ''They must be flexible. You have endocytosis, exocytosis, all these processes which involve dynamic reorganizations of membranes.''

The membrane that surrounds a cell or the organelles within cells is made of two layers of phospholipids-microscopic ''lollipops'' with water-loving (hydrophilic) heads that point outward and water-fearing (hydrophobic) tails that point inward. The cell membrane is studded with proteins like receptors and ion channels, which cross the membrane many times and transmit signals from the outside of the cell to the inside. Others don't cross the membrane at all-they are anchored to the membrane by lipid-like entities or by single transmembrane helices. The membrane is a fluid and components can move around laterally to differing degrees, like swimmers in a pool. The Nan
'"/>

Source:Stanford University


Page: 1 2 3 4 5 6

Related biology news :

1. Space matters: Estimating species diversity in the fossil record
2. Nano springs eternal; Protozoan engine posts nano records
3. Immunization rates hit record high in poor countries
4. New law for resolution allows unprecedented sharpness in fluorescence microscopy
5. High resolution snapshots detail dynamics of a cocaine antibody
6. High-resolution light microscope reveals the fundamental mechanisms of nerve communication
7. Recombination protein dynamics observed with single monomer resolution
8. New MRI technique quickly builds 3-D images of knees
9. Everything in its place: Researchers identify brain cells used to categorize images
10. Novel computed imaging technique uses blurry images to enhance view
11. Ultrasound upgrade produces images that work like 3-D movies
Post Your Comments:
(Date:7/8/2008)...hington, DC July 8, 2008) A new partnership betwe...) Office of Research and Development (ORD) and the...iversity of Vermont will help decision makers more...tions that alter ecosystem services -- the goods a... erosion and flood control, soil enrichment, and f...
(Date:7/8/2008)...e effective treatment of many forms of cancer cont...umours fail to respond to standard forms of chemot...ntists at the Helmholtz Centre for Infection Resea...hool (MHH) and Leibniz-Universitt (LUH) in Hanover...ch a natural substance - argyrin - destroys tumour...
(Date:7/8/2008)..., , NEW BRUNSWICK, N.J. Three plant biologists... obsessed with duckweed, a tiny aquatic plant with...ederal government to focus its attention on duckwe...n, combating global warming and feeding the world....ng energy and environmental research and the impor...
(Date:7/8/2008)...s release is available in Spanish . , Barce... embryo has been replaced in the womb have higher ...ere used, Danish scientists reported to the 24th a...Reproduction and Embryology today (Tuesday 8 July)...dren did not show an increased risk of congenital ...
Breaking Biology News(10 mins):US EPA, UVM's Gund Institute team up to develop new ways to understand ecosystem services 2Argyrin: Natural substance raises hope for new cancer therapies 2Duckweed genome sequencing has global implications 2Children born from frozen embryos weigh more and do better than those born after fresh transfer 2Intel Co Founder Andrew S Grove Dedicates Portion of His Estate Up to 2440 Million to Michael J Fox Foundation 9422 1Intel Co Founder Andrew S Grove Dedicates Portion of His Estate Up to 2440 Million to Michael J Fox Foundation 9422 2Intel Co Founder Andrew S Grove Dedicates Portion of His Estate Up to 2440 Million to Michael J Fox Foundation 9422 3BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J Simon M D as Interim Chief Medical Officer To Meet Growing Product De 2552 1BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J Simon M D as Interim Chief Medical Officer To Meet Growing Product De 2552 2BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J Simon M D as Interim Chief Medical Officer To Meet Growing Product De 2552 3BioCryst Strengthens Its Expertise in Clinical Development By Adding Thomas J Simon M D as Interim Chief Medical Officer To Meet Growing Product De 2552 4Memantine and Alzheimers disease 9416 1Memantine and Alzheimers disease 9416 2Memantine and Alzheimers disease 9416 3Priming Heart Before an Attack Could Limit Damage 9413 1Priming Heart Before an Attack Could Limit Damage 9413 2Priming Heart Before an Attack Could Limit Damage 9413 3
... HIV-infected patients in India has risen in respo...al therapy (ART), according to an article in the N...available online. The introduction of generic drug...IV treatment because of the cheaper cost, the arti...infected people living in India have been unable t...
...ns Hopkins have discovered the presence of functio...Cs). These ion channels act like electrical wires ...unique ability to become all cell types of the bod...If researchers could selectively block some of the...cells, they may be able to prevent potential tumor...
...eaten back pink bollworm eight years running, repo...izona in Tucson. , The surprising finding is good ...t the biotech cotton known as Bt cotton use substa...t. , Insect pests sometimes evolve resistance to ...s predicted for biotech crops genetically altered ...
...l kingdom, rival males routinely challenge one ano...collisions between bighorn rams to the ritualized ...often the key to reproductive success. , But now ...ish have discovered that low-ranking male cichlids...ng up a fight. In fact, a drab subordinate male ci...
Other Biology News:HIV mortality in India drops with introduction of generic antiretroviral therapy 2Stem cells' electric abilities might help their safe clinical use 2Biotech cotton 8: Bugs 0 2Biotech cotton 8: Bugs 0 3Sudden change in social status triggers genetic response in male fish, study finds 2Sudden change in social status triggers genetic response in male fish, study finds 3Sudden change in social status triggers genetic response in male fish, study finds 4Sudden change in social status triggers genetic response in male fish, study finds 5Sudden change in social status triggers genetic response in male fish, study finds 6
(Date:7/8/2008)...uly 8 /- Knowledge Enterprises, Inc.,... the release of The,2007-2008 Orthopaedic Industry... accurate, strategically oriented industry data. T...obal orthopaedic market through,sections dedicated...y/Soft,Tissue Repair, Spinal Implants and Instrume...
(Date:7/8/2008)...y 8 /- The world chemical and,pharmac...sey in early,September to attend the Pharma ChemOu...ls sourcing event is geared to top pharmaceutical ...ecord turnout. The popular,seaside venue has had t...,to house the hordes of delegates who will descend...
(Date:7/8/2008)...8 /Xinhua-- China-Biotics,..."the Company"), a leading,Chinese firm specializin...ting and distribution of probiotics products, toda...f Technology Officer, has been invited to,be the g...hnology Forum,2008 (the "Forum")., The Forum, org...
(Date:7/8/2008)... Expanded Commercialization of the Revolutionary ...--, ANN ARBOR, Mich., July 8 /- Accu...ping revolutionary bench-top flow cytometer system... Series C financing led by,Fidelity Biosciences an...aird Venture Partners and Arboretum Ventures also ...
Breaking Biology Technology:Knowledge Enterprises, Inc. and The Institute for Orthopaedics(TM) Release The 2007-2008 Orthopaedic Industry Annual Report 2World Chemical Industry Has Decided to Gather at ChemOutsourcing Show on September 7-9 in New Jersey 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 3Accuri Cytometers Completes $13 Million Series C Financing 2Accuri Cytometers Completes $13 Million Series C Financing 3Accuri Cytometers Completes $13 Million Series C Financing 4
... In clinical research, the monitoring of proteas...riptase inhibitor (NNRTI) antiretroviral drugs is ...ssessing inter-individual and intra-individual met... essential that the analytical method used to moni...minimal sample preparation, and without compromisi...
...ucleotide Kinase (PNK) (1,2,3) is commonly used f...and oligonucleotides. Labeling, in particular, can...action and the exchange reaction (Fig. 1) (3) . Hi...lecular biology and it continues to be important i...idization, sequencing or mapping of transcripts an...
...mple high performance liquid chromatograph tandem ...or a simultaneous analysis of the metabolites of f... Abstract , The animal meat sample... washes, hydrolysis and derivatization followed by...he limits of detection were 0.05-0.15 ng/g animal ...
... liquid chromatography/ mass spectrometry and info...s spectrometry, it has become possible to characte...s during metabolic stability studies. This was onc... Abstract , The Q TRAP instrument ...pable of doing conventional multiple reaction moni...
Other Biology Technology:A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 2A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 3A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors) 4 USB OptiKinase Eliminates Base Bias in Labeling of Oligonucleotide 5'-Ends 2 USB OptiKinase Eliminates Base Bias in Labeling of Oligonucleotide 5'-Ends 3High sensitivity quantitation of metabolites of nitrofuran antibiotics in animal tissue using LC/MS/MS 2High sensitivity quantitation of metabolites of nitrofuran antibiotics in animal tissue using LC/MS/MS 3Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS 2Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS 3Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS 4Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS 5
Request Info
...Ultrospec 6300 pro UV/Visible Spectrophotometer: ...poeia in terms of instrument specification and GLP... to be used for rapid, discrete measurements., *Ba...y., *Press to read high performance deuterium and ...
Cy3 Ab Labeling Kit, 1 kit. Convenient way to tag antibodies with CyDye fluorescent dyes. Conjugations are carried out under mild conditions and are complete within 1 h. Dyes are packaged in prem
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA
Biology Products: