Navigation Links
With few factors, adult cells take on character of embryonic stem cells

s in the induction of pluripotency" in other body cells, he explained.

The researchers selected 24 genes--all previously found to play a role in early embryos and embryonic stem cell identity--as candidate factors that might give body cells the ability to become other cell types.

The researchers found that four of those factors, known as Oct3/4, Sox2, c-Myc, and Klf4, could lend differentiated fibroblast cells taken from embryonic or adult mice the pluripotency normally reserved for embryonic stem cells.

They further reported that transplantation of the iPS cells under the skin of mice resulted in tumors containing a variety of tissues representing the three primary types found in mammalian embryos. Those primary "germ layers" in embryos eventually give rise to all an animal's tissues and organs.

Following injection into blastocysts, iPS cells also contributed to mouse embryonic development.

"The finding is an important step in controlling pluripotency, which may eventually allow the creation of pluripotent cells directly from somatic cells of patients," Yamanaka said.

While the findings could have wide applications, stem cell experts caution that the study of embryonic stem cells has much further to go.

"We still do not know whether the four factors can generate pluripotent cells from human somatic cells," Yamanaka said. Use of c-Myc, a gene implicated in many human cancers, may not be suitable for clinical applications, they added, and the process may require specific culture environments. It also remains unclear whether iPS cells can do everything that embryonic stem cells can.


'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. With few factors, adult cells take on character of embryonic stem cells
2. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
3. Study finds adult stem cells can replicate
4. Researchers discover mechanism for multiplying adult stem cells
5. Suppressing growth hormone in early adulthood may prevent cancer
6. A new window into structural plasticity in the adult visual cortex
7. MIT researcher finds neuron growth in adult brain
8. New neurons take baby steps in the adult brain
9. Neurons generated in the adult brain learn to respond to novel stimuli
10. Changes to embryos can elicit change in adult fish
11. Feds give researchers ok for safety test of adult stem cells in patients with heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: With few factors adult cells take character embryonic stem cells

(Date:11/4/2014)... Nov. 5, 2014 – University of Utah engineers developed ... help jet fuel produce electricity without needing to ignite ... to power portable electronics, off-grid power and sensors. , ... in the American Chemical Society journal ACS Catalysis ... a chemical reaction between a fuel and an oxygen-rich ...
(Date:11/4/2014)... Think about the way our bodies are assembled during ... that they are supposed to become a nerve or ... the correct place and alignment? Researchers at the University ... In a new study, UM researchers describe the signaling ... neighbors, at the head-trunk region. Their discovery may have ...
(Date:11/4/2014)... HOUSTON – (Nov. 4, 2014) – A majority of ... and that could have serious consequences for the rainforests ... researchers shows the positive impacts lemurs can have on ... impact their disappearance could have on the region,s rich ... rainforest have fruits eaten by lemurs. Lemurs in ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2The inside story: How the brain and skull stay together 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... Alberta researcher has discovered a rare practice by red squirrels ... its heart is also a survival tactic. U ... when he discovered a female had adopted a newborn squirrel ... candidate in evolutionary biology, found a baby red squirrel had ...
... funded by the U.S. economic stimulus program (ARRA) Health ... to advance the use of health information technology (HIT) ... been awarded to leading members of the American Medical ... the last two decades has advocated for informatics as ...
... and Space Sciences More than 2,200 scientists are ... sciences in Foz do Iguau at the 2010 Meeting of ... 8 to 12 August, are planning 377 scientific sessions on ... weather events in the Americas, climate impacts of megacities, greenhouse ...
Cached Biology News:Red squirrels: Altruists or self-serving survivalists? 2AMIA Members Manage HITECH Stimulus Grant Awards 22010 Meeting of the Americas, Brazil: News media registration open 22010 Meeting of the Americas, Brazil: News media registration open 32010 Meeting of the Americas, Brazil: News media registration open 4
(Date:11/22/2014)... During his lifetime Richard L. Sharp ... surround himself with great people and take risks to ... often marveled at his extraordinarily courageous attitude when taking ... -- even with his death impending—that’s how he continued ... would ultimately take his life. , Carrying on Sharp’s ...
(Date:11/22/2014)... Colo. (PRWEB) November 21, 2014 ... proprietary cloud based analytics and scientific testing methodologies relating ... commitment for a $750,000 line of credit from an ... extremely pleased to have secured this commitment from one ... Executive Officer of CannLabs. “This capital will help accelerate ...
(Date:11/22/2014)... IL (PRWEB) November 21, 2014 On ... competitors at the 2014 Emerging Medical Technologies Summit in ... Innovator Awards. Widely regarded among Silicon Valley investors ... medical device innovation, the win also positions Briteseed ... MedTech Innovator competition in 2015 and compete with other ...
(Date:11/22/2014)... 22, 2014 Respiratory therapy students ... proper management of life-like respiratory ailments using the ... . Grand Rapids-based, Michigan Instruments Inc. developers of ... of the respiratory simulation units to the pro-gram, ... Valley and Muskegon Community College are collaborating to ...
Breaking Biology Technology:Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3CannLabs Secures $750,000 Line Of Credit 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3
... 2011 The Jackson Laboratory (JAX), Sackler School of Graduate ... have unveiled a new mammalian genetics track for Ph.D. students. ... both JAX and Tufts. Combining the faculty and resources of ... disease, and the faculty and resources at JAX, with its ...
... EAST BRUNSWICK, N.J., Jan. 7, 2011 Savient Pharmaceuticals, Inc. ... its business activities related to the U.S. launch and commercialization ... the treatment of chronic gout in adult patients refractory to ... track for the promotional launch of KRYSTEXXA in the first ...
... Biopharma, a biopharmaceutical company developing novel and biosuperior ... that the company has entered into a multi-year ... commercialization of novel peptide-based therapeutics. Under ... receive an upfront payment of an undisclosed amount, ...
Cached Biology Technology:The Jackson Laboratory and Tufts University Announce New Ph.D. Track in Mammalian Genetics 2The Jackson Laboratory and Tufts University Announce New Ph.D. Track in Mammalian Genetics 3Savient Pharmaceuticals Provides Business Update 2Savient Pharmaceuticals Provides Business Update 3Savient Pharmaceuticals Provides Business Update 4Savient Pharmaceuticals Provides Business Update 5Savient Pharmaceuticals Provides Business Update 6Sutro Biopharma Forges Partnership with Pfizer for Discovery, Development and Commercialization of Novel Peptide-Based Therapeutics 2
Mouse polyclonal antibody raised against a partial recombinant KCTD13. NCBI Entrez Gene ID = 253980...
... direct antibiotic-based selection system for recombinant identification. ... eliminating the need for costly color screening. ... to 100% accuracy in recombinant selection. pLivSelect ... colony picking. This cloning kit is ...
Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP). [Source:Uniprot/SWISSPROT;Acc:P08697] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Mouse monoclonal antibody raised against a partial recombinant ZNF167. NCBI Entrez Gene ID = ZNF167...
Biology Products: