Navigation Links
With few factors, adult cells take on character of embryonic stem cells

With the introduction of just four factors, researchers have successfully induced differentiated cells taken from mouse embryos or adult mice to behave like embryonic stem cells. The researchers reported their findings in an immediate early publication of the journal Cell, published by Cell Press.

The cells--which the researchers designate "induced pluripotent stem cells" (iPS)--exhibit the physical, growth, and genetic characteristics typical of embryonic stem cells, they reported. "Pluripotent" refers to the ability to differentiate into most other cell types.

"Human embryonic stem cells might be used to treat a host of diseases, such as Parkinson's disease, spinal cord injury, and diabetes," said Shinya Yamanaka of Kyoto University in Japan. "However, there are ethical difficulties regarding the use of human embryos, as well as the problem of tissue rejection following transplantation into patients."

Those problems could be circumvented if pluripotent cells could be obtained directly from the patients' own cells.

"We have demonstrated that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors," Yamanaka said. Fibroblasts make up structural fibers found in connective tissue.

Embryonic stem cells are derived from inner cells of the mammalian blastocyst, a ball of cells that develops after fertilization and goes on to form a developing embryo. Cells from other parts of the body can also be "reprogrammed" by transferring their nuclear contents into egg cell precursors called oocytes or by fusion with embryonic stem cells, earlier studies showed.

Those findings provided evidence that unfertilized eggs and embryonic stem cells contain factors that can confer pluripotency to differentiated cells, Yamanaka said.

"We hypothesized that the factors that play important roles in the maintenance of embryonic stem cell identity also play pivotal role
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. With few factors, adult cells take on character of embryonic stem cells
2. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
3. Study finds adult stem cells can replicate
4. Researchers discover mechanism for multiplying adult stem cells
5. Suppressing growth hormone in early adulthood may prevent cancer
6. A new window into structural plasticity in the adult visual cortex
7. MIT researcher finds neuron growth in adult brain
8. New neurons take baby steps in the adult brain
9. Neurons generated in the adult brain learn to respond to novel stimuli
10. Changes to embryos can elicit change in adult fish
11. Feds give researchers ok for safety test of adult stem cells in patients with heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: With few factors adult cells take character embryonic stem cells

(Date:7/25/2014)... the age girls reach puberty is influenced by ,imprinted genes,a ... contributes the gene. This is the first evidence that ... and details of this study were published today in the ... known as menarche, is a marker for the timing of ... of menses varies between girls, is an inherited trait, and ...
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
(Date:7/24/2014)... the use of native animal species for food or ... a significant factor in the decline of many species ... study indicates that more than half of the species ... and hornbills., "By surveying not only the meat made ... eaten inside the forest by hunters and brought to ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2
... SEATTLE Harmit Singh Malik, Ph.D., an evolutionary ... the 2010 Vilcek Prize for Creative Promise in Biomedical ... cash prize, for his research on the co-evolution of ... "immigrant achievement in biomedical science and arts." Malik was ...
... to our understanding of the complex chain of chemistry that ... University of Vermont (UVM), the University of Utah, Vanderbilt University ... demonstrated for the first time the specific activity of the ... integrity of DNA in humans and other mammals. Their work ...
... the sun were easy, we wouldn,t still have the greenhouse ... And while solar energy systems work moderately well in hot ... small percentage of the general energy demand. A new ... source that may be on your dinner plate tonight. ...
Cached Biology News:Dr. Harmit Malik receives Vilcek Prize for creative promise in biomedical science 2Mouse work: New insights on a fundamental DNA repair mechanism 2A new energy source from the common pea 2
(Date:7/25/2014)... of bacteria live in each person,s digestive tract. Scientists ... and stave off harmful infections, but their role in ... shed light on the role of these bacteria, a ... Alm recently tracked fluctuations in the bacterial populations of ... described in the July 25 issue of the journal ...
(Date:7/25/2014)... Albany, New York (PRWEB) July 25, 2014 ... Transparency Market Research, "Biological Drugs Market - Global Industry ... 2020," the global biological drugs market is estimated at ... grow at a CAGR of 10.1% from 2014 to ... million in 2020. , The biological drugs market is ...
(Date:7/25/2014)... July 25, 2014 Lawrence Livermore scientists ... Thomson Reuters list of " The World's Most Influential ... of the 3,000 researchers who were identified by analyzing ... those who published the highest-impact work (2002-2012 and 2012-2013). ... on combustion modeling . , "This recognition is ...
(Date:7/25/2014)... At the request of the AMA, the ... for the public comment period (Docket No. FAA-2014-0396) for ... established by Congress as part of the FAA Modernization ... the new deadline for comments as September 23, 2014. ... published in the Federal Register on July 25, 2014, ...
Breaking Biology Technology:Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4FAA Grants Comment Extension at the Request of AMA 2
... Blocks of carbon nanotubes can be used to create ... study by researchers at Rensselaer Polytechnic Institute. , Taking ... researchers repeatedly squeezed a 3-millimeter nanotube block and discovered ... pressure sensor. No matter how many times or how ...
... Systems, Inc. (Sparta),the maker of TrackWise(R), and the ... announced that its TrackWise solution has,been chosen by ... development, manufacturing and marketing of specialized products for,critical ... complaint handling,processes. TrackWise provides organizations with a ...
... Human Genome,Sciences, Inc. (Nasdaq: HGSI ) today ... its financial results for the quarter ended,September 30, 2007. ... 1, 2007. (Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO ) The ... will be,held on Thursday, November 1, 2007, at 11:00 ...
Cached Biology Technology:The sensitive side of carbon nanotubes: Creating powerful pressure sensors 2The sensitive side of carbon nanotubes: Creating powerful pressure sensors 3Protherics UK Ltd. Chooses TrackWise for Corrective Action and Preventive Action (CAPA) Management 2Human Genome Sciences To Sponsor Conference Call To Discuss Third Quarter 2007 Financial Results 2
cysteine and glycine-rich protein 2,...
... pan B (B220), 4.5 m, coated ... efficient positive isolation or depletion of ... or lymph node cell suspensions. B220 ... cells and lytically active subsets of ...
Gap junction protein, beta 2, 26kDa (connexin 26) Antigen: Peptide...
NAP-2 (5C7)...
Biology Products: