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Wisconsin scientists grow critical nerve cells

truck by an idea: Why not apply a chemical known to be necessary for a later stage of neuron development to a much earlier step in the process?

The hunch paid off and turned out to be the final piece of the puzzle.

The discovery, says Zhang, demonstrates that human stem cells do not necessarily differentiate in linear fashion, as scientists always believed. Rather, a series of complex overlapping changes may well be the developmental norm in higher vertebrates such as humans.

"We cannot simply translate studies from animal to humans," says Zhang.

The next step, Li says, will be to test if the newly generated neurons can communicate with other cells when transplanted into a living animal. The team will first test the neurons in chicken embryos.

While the new results are promising and provide access to critical cells that may one day be used in therapy, it will likely be many years before they can be tested in humans, Zhang says.


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Source:University of Wisconsin-Madison


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