Navigation Links
Wild gorillas carriers of a SIV virus close to the AIDS virus

In 2005, 40.3 million people in the world, including 25.8 million in Sub-Saharan Africa, were living with HIV. The question of the origin of HIV-1, responsible for the AIDS pandemic, has been stimulating the scientific community for many years.

Some months ago, the team of Martine Peeters, director of research at IRD, and Eric Delaporte, director of the mixed research unit UMR 145 jointly involving the IRD and the University of Montpellier 1, showed the chimpanzee subspecies living in the Congo Basin (2) to be the reservoir of HIV-1 virus group M, the source of the world pandemic and that of another, very rare variant, HIV-1 group N. However, the reservoir of the third HIV-1 group, group O which infects humans (3), remained unidentified up to now.

This team announces, in an article in the journal Nature, the discovery of a simian immunodeficiency virus (SIV) infection in wild gorillas. Samples of faeces collected from different communities of gorillas found in the remotest areas of the Cameroon tropical forest were found to contain antibodies against this virus, called SIVgor. The genetic characteristics of the virus were present again in three gorillas living more than 400 km apart. Phylogenetic analysis of SIVgor showed it to be related to HIV-1 group O found in humans, essentially in Cameroon and in neighbouring countries.

This discovery of an HIV-1 related virus in wild gorillas does not, however, call into question the fact that chimpanzees are the primary reservoir of SIV/HIV viruses that crop up again in gorillas and in humans. As Martine Peeters of the IRD says, "the viruses of groups M and N are, very clearly, the consequence of inter-species transmission from chimpanzee to humans, whereas the origin of HIV-1 group O is less apparent. It cannot be excluded that chimpanzees infected by HIV-1 group O might have contaminated humans and the gorilla independently, or that the gorilla, having been contaminated by the chimpanzee, might hav e contaminated humans".

This work thus opens up a Pandora's box on the questions and speculations concerning the ability of these viruses to cross over from one species to another. The main challenges facing these teams for future work will be determination of the prevalence, the geographical distribution and biology of SIV infections in these great apes, not forgetting the question of how the gorillas were contaminated. This last point remains a mystery,considered as rare.
'"/>

Source:Institut de Recherche Pour le D茅veloppement


Related biology news :

1. Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
2. Poaching, logging, and outbreaks of Ebola threaten central African gorillas and chimpanzees
3. Bronx Zoo bears are new Samsonite gorillas
4. Ebola-outbreak kills 5000 gorillas
5. Ugandas mountain gorillas increase in number
6. Ebola outbreaks killing thousands of gorillas and chimpanzees
7. Association of herpesvirus with lung disorder questioned
8. Topical treatment shown to inhibit HIV and herpes simplex virus infection
9. Elusive HIV shape change revealed; Key clue to how virus infects cells
10. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
11. Live Recombinant Adenovirus Vaccine Technique Explored

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... ... 2017 , ... Cancer diagnostics and pathology workflow solution provider ... Association for Pathology Informatics Annual Summit at the Wyndham Grand Hotel ... Diagnostic Cockpit and Consultation Portal, Inspirata will present research it led to help ...
(Date:5/19/2017)... , ... May 19, 2017 , ... In response to ... gait disorders, Biodex Medical Systems, Inc. announces the release of their Gait Trainer 3 ... been joined with a biomedical system to aid in rehabilitating individuals with cerebral palsy, ...
(Date:5/18/2017)... ... May 18, 2017 , ... Lajollacooks4u has added ... is a two-hour team-building package designed for groups of 10-30 people. Guests ... which include items, such as Blackened Shrimp with Edamame Salad, Pizza Rolls with ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... its scientific power by providing investigators access to a high-profile scientific advisory ... the scientific advisory board. “We are committed to offering superior services and ...
Breaking Biology Technology: