Navigation Links
Why mice don't get cancer of the retina

Humans are more susceptible to developing the eye cancer retinoblastoma than mice because, unlike humans, mice can compensate for the loss of activity of a gene critical to normal retinal development , according to results of a study by investigators at St. Jude Children's Research Hospital. The study, published today in the open access journal BMC Biology, explains why humans with a defective copy of the Retinoblastoma gene RB1 are at high risk of developing cancer of the retina, or retinoblastoma, whereas mice with a similar genetic profile do not develop the cancer.

Stacy Donovan and Brett Schweers from St Jude Children's Research Hospital in Memphis, USA and colleagues from St Jude's and from the University of Tennessee Health Science Center in Memphis, studied the expression of the Retinoblastoma proteins Rb (RB1 in humans), p107 and p130 throughout the development of mouse and human retinae, using molecular amplification and immunolabelling techniques.

Donovan et al. find that p107, Rb and p130 are expressed at different stages in the developing mouse retina, with p107 expressed first and Rb and 130 expressed during the late stages of development. The authors show that, in mutant mouse embryos that do not express Rb at all, the levels of p107 are much higher than in wild-type embryos at the same stage in development. The reverse situation is observed in mutant embryos that do not express p107. This suggests that Rb and p107 compensate for each other in retinal progenitor cells and prevent the deregulated proliferation of the cells that leads to retinoblastoma. By contrast, RB1 is the main protein expressed during retinal development in humans. The protein p107 is only slightly expressed during development and cannot compensate for the lack of RB1, which leads to retinoblastoma.


'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Penguins waddle but they dont fall down, UH researchers say
2. Nearly half of people who need cholesterol treatment dont get it
3. Study: Paramedics save more lives when they dont follow the rules
4. Even fish dont swim well when theyre young!
5. One-third of adults with diabetes still dont know they have it
6. Survival of the selfless - scientists find cheats dont always prosper
7. Why dont all moles progress to melanoma?
8. New cigarette designs dont offer lower predicted cancer risks
9. Some caterpillers just dont want to grow up
10. Mosquito repellents that emit high-pitched sounds dont prevent bites
11. When your brain talks, your muscles dont always listen
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology: