Navigation Links
Why don't all moles progress to melanoma?

ess and gets rid of excess incoming amino acids, giving the ER a chance to catch up. If that doesn't work, the UPR causes the cell to destroy itself in a process called apoptosis.

"Traditionally, the ER's role was considered to be limited to protein folding or protein modification," Soengas says. "But scientists like Randal Kaufman, a U-M professor of biological chemistry and co-author on our paper, have found that the ER can sense changes in glucose, nutrients, oxygen levels and other aspects of cellular physiology associated with diseases like diabetes and Alzheimer's disease."

"In our study, we found that the ER senses the activity of certain oncogenes in the melanocyte and triggers a response that prevents the malignant transformation of these cells," Soengas adds.

According to Soengas, the tumor suppressive mechanism induced by the ER in melanocytes with these cancer-causing mutations is premature senescence ?a form of "suspended animation" that stops the cell cycle and keeps cells from dividing, but doesn't kill them.

"The cells are held in check ?they don't die, but they don't proliferate either," Soengas explains. "In the case of moles, melanocytes can stay this way for 20 to 40 years or even your whole life. For most of us, just holding cells in an arrested state is sufficient to prevent the development of cancer. That's why so many people have moles, but few have melanoma."

In the study, U-M scientists found that the tumor suppressive response in melanocytes varied depending on the type of oncogene being expressed in the cell.

"We found that some oncogenes activated the endoplasmic reticulum, while other oncogenes didn't," Soengas says.

In a previous study, Soengas and colleagues found that certain oncogenes use a different senescence mechanism, which doesn't activate the ER, to block the transformation of melanocytes. Both these mechanisms work in addition to or independent from other well-
'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. Penguins waddle but they dont fall down, UH researchers say
2. Nearly half of people who need cholesterol treatment dont get it
3. Study: Paramedics save more lives when they dont follow the rules
4. Even fish dont swim well when theyre young!
5. One-third of adults with diabetes still dont know they have it
6. Survival of the selfless - scientists find cheats dont always prosper
7. Why mice dont get cancer of the retina
8. New cigarette designs dont offer lower predicted cancer risks
9. Some caterpillers just dont want to grow up
10. Mosquito repellents that emit high-pitched sounds dont prevent bites
11. When your brain talks, your muscles dont always listen
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Why don all moles progress melanoma

(Date:3/2/2015)... March 2, 2015  Businesses have a new ... company Tharon Rankins Enterprises has announced the launch ... ultra-safe way for businesses to protect their customers, ... Beconux is a biometric transaction ... Functioning similarly to an ATM machine, the new ...
(Date:2/24/2015)... This report analyzes the worldwide markets for Iris ... for the US, Canada , ... Asia-Pacific , Middle East , and ... are provided for the period 2013 through 2020. Also, a ... and analytics are derived from primary and secondary research. Company ...
(Date:2/23/2015)... , Feb. 23, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... filed provisional patent 62114357 for DISTRIBUTED VOICE ... patent, NXT-ID introduces a new groundbreaking payment method. Payment ... payment account may only be accessed if both the ...
Breaking Biology News(10 mins):Personal Data Protection Company Launches New Product 2World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
... clearly defined male or female genitals experience a roller-coaster of emotions, ... to a study in the October issue of the Journal ... parents found that they were keen to find a sense of ... them as. "The parents we spoke to went through ...
... SCOTTSDALE, Ariz. Sept. 28, 2011 ... award from the Arizona BioIndustry Association (AZBio) for ... TD2, a subsidiary of the Translational Genomics Research ... to biopharmaceutical companies using cutting-edge technology to minimize ...
... COLUMBIA, Mo. The average yearly energy savings for ... (MoIAC) is $80,000. However, the true cost savings are ... energy conservation. To help educate those future leaders, ... $1.5 million grant to the MoIAC for the next ...
Cached Biology News:Parents feel shock, anxiety and the need to protect children with genital ambiguity 2Parents feel shock, anxiety and the need to protect children with genital ambiguity 3TGen Drug Development recognized for economic development of Arizona biosciences 2MU Industrial Assessment Center saves companies thousands, trains future energy efficiency experts 2
(Date:3/4/2015)... Korea , March 4, 2015 Vegalab ... company, in August of last year. As part of ... Kyung Bon Koo continuing his role as CEO ... President of Vegalab S.A., will work alongside Koo and ... Photo - http://photos.prnewswire.com/prnh/20150303/179218 Koo ...
(Date:3/4/2015)... ANDOVER, Massachusetts , March 4, 2015 /PRNewswire/ ... Unternehmen präsentiert innovative Entwicklungen für Diagnostik und Therapie, ... Gesundheitsversorgung   Royal Philips ... am Europäischen Röntgenkongress 2015 (ECR) bekannt, ... stattfindet. An den Ständen Nr. ...
(Date:3/3/2015)... Experts and industry insiders from around the ... Alltech REBELation exploring innovation, inspiration and world-changing ideas in ... 31st year, Alltech’s annual international conference traditionally draws more ... to join the REBELation at an extra discount registration ... at which point the standard early registration rate will ...
(Date:3/3/2015)... TORONTO , March 3, 2015 /CNW/- SQI Diagnostics ... and commercializes proprietary technologies and products for advanced ... Ryer CPA, CA, CFE  to its Management team. ... the Company in its transition from a development ... financing initiatives to advance the Company,s capital market ...
Breaking Biology Technology:Korean Government Program Supports Vegalab's Research and Development 2Korean Government Program Supports Vegalab's Research and Development 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 2Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 5Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 6World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3
... At this year,s Drug Information Association Annual Meeting ... - the first mobile biorepository designed specifically for ... transport technology allows for the customized transportation of ... the shipment reaches its destination on time and ...
... The world,s leading researchers in cardiovascular medicine will ... Echocardiography (ASE) 22nd Annual Scientific Sessions, June 11-14, 2011 ... will significantly impact the diagnosis and treatment of heart ... To view the full text of the press releases, ...
... CHICAGO, June 10, 2011 The neurological system is ... The human brain performs so many amazing tasks on ... surprise that over 600 brain disorders have currently been ... and neurosurgeons. The American Academy of Neurology, The Congress ...
Cached Biology Technology:BioStorage Technologies Showcases First-Ever Mobile Biorepository - Relofleet™ at Drug Information Association Annual Meeting 2Researchers From More Than 30 Countries Share Findings About the Use of Ultrasound in the Prevention, Diagnosis and Treatment of Heart Disease 2Mediaplanet Launches Campaign for Awareness of Neurological Issues 2
...
... walled plates enhance luminescent signals and ... Not treated (or medium binding) polystyrene ... binds biomolecules through passive interactions,• Is ... large molecules, such as antibodies, that ...
... H-IPMIK-OH Lyophilized solid. Supplied as ... PACKAGED UNDER INERT GAS. A cell-permeable mutated ... No. 196810) that serves as a negative ... μM). Purity: ≥97% by HPLC. ...
...
Biology Products: