Navigation Links
Why do aneurysms form? New studies suggest leading role for white blood cells

e rodents that had low neutrophil levels or no neutrophil-attaching protein developed little or no sign of aneurysm. Meanwhile, the injury to the aorta wall prompted the rapid formation of aneurysms in the normal rodents -- aneurysms that made the diameter of the blood vessel double or even quadruple.

In an accompanying editorial, Columbia University surgeon M. David Tilson, M.D., notes that the studies bring research on AAA formation and the role of the neutrophil to a new level and may lead to further discoveries that help sort out the AAA puzzle.

AAAs are an under-appreciated and under-researched public health threat, says Upchurch, who operates on dozens of AAA patients each year, including some whose aneurysms have already burst and who will die within minutes or hours if the bleeding isn't stopped. AAAs can go undetected for years; experts sometimes refer to them as a "ticking time bomb" inside a patient's abdomen.

In fact, an estimated 10 percent of all men over the age of 70 may have intact aortic aneurysms, which cause few symptoms except for occasional back pain or abdominal discomfort. If they are detected during this stage, for instance on a routine physical exam, X-Ray, MRI or CT scan, they can be repaired successfully 95 percent of the time.

Recently, new ideas about why aneurysms form have begun to take shape. "We're finding that in general, an aneurysm is an inadequate response to injury," Upchurch explains. "Something happens to damage elastin fibers in the blood vessel wall and, for some reason, the immune system's normal healing response doesn't work. Something eats away at smooth muscle cells in the wall of the aorta until it starts to fall apart."

Researchers have found that AAAs appear to be associated with high levels of enzymes that are capable of doing that eating. But the question of how those enzymes get there, and what prompts them to arrive, has been unanswered.

"Neutrophils are known to ca
'"/>

Source:University of Michigan Health System


Page: 1 2 3 4

Related biology news :

1. New studies suggest airborne SARS transmission is possible
2. Two studies document rise of superbugs in the environment
3. UI researcher studies deafness in fruit flies, humans
4. Biased reporting found in cancer prognostic studies
5. Fruit fly studies open new window on cancer research
6. Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
7. Diabetes researchers pioneer islet cell xenotransplantation in primate studies
8. Pair of studies offer new clues to combat antibiotic resistance
9. New RNAi tools enable systematic studies of gene function
10. Ernst Mayrs theory illustrated in genetic epidemiology studies
11. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
Post Your Comments:
(Date:8/29/2014)... Until recently, little has been known about what genetic ... team of scientists, one of whom is a University ... showing that genes controlling the development of the brain ... domestication., The study was published Aug. 28 in ... It is online at http://www.sciencemag.org/ ., The domestication ...
(Date:8/29/2014)... understand how the repeated climatic shifts over the ... of genetic diversity, a team of researchers led ... Ana Carnaval developed a new biodiversity metric called ... which the genetic variation within species is restricted ... professor of biology, and 14 other researchers from ...
(Date:8/29/2014)... is available in German . ... in the natural nitrogen cycle on Earth and in ... were thought to depend on nitrite as their source ... Holger Daims, a microbiologist at the University of Vienna, ... as an alternative source of energy. The oxidation of ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3CCNY team defines new biodiversity metric 2Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3
... At a recent Kavli Futures Symposium, 19 experts from ... the lab to understand and exploit the evolution of organisms ... or other biotechnology products. Now, three of the participants ... raised during the meeting: Michael Brenner, Professor of Applied Mathematics ...
... Tampa, Fla. (June 28, 2011) Mensenchymal stem cells ... tissues, have been shown to be therapeutically effective in ... assisting in skin wound healing, and suppressing chronic airway ... are being prepared for therapeutic applications, they are cultured ...
... device to reduce the risk of infection, clotting and narrowing ... because of kidney failure. The device, designed to be ... a technician easy access to the patient,s bloodstream and could ... of a dialysis procedure. The prototype has not yet ...
Cached Biology News:Beyond Darwin: Evolving new functions 2Serum-free cultures help transplanted MSCs improve efficacy 2Student team invents device to cut dialysis risk 2
(Date:8/28/2014)... NEW YORK , Aug. ... announces that a new market ... its catalogue: Whole ... (Systems, Kits (Library Preparation, Target ... Technology (Sequencing by Synthesis), by ...
(Date:8/28/2014)... SunTrust Robinson Humphrey (STRH) today announced the ... research team in biotechnology and oilfield services.  ... demonstrates our commitment to providing our valued institutional ... decision making," said Biff Woodruff , Head ... significant investments in differentiated content at a time ...
(Date:8/28/2014)... by a Florida State University research team has led ... temperature, emit white light, and convert photon energy directly ... a butterfly. , Biwu Ma, associate professor in the ... College of Engineering, created the molecule in a lab ... that his creation has many other unique capabilities. , ...
(Date:8/28/2014)... Earlier this month, a report was created by ... Air Force on the performance of vehicles using an ... of fuel made from mustard seeds, offered great potential ... Eco friendly future. In fact, every branch of the ... of foreign oil over the next few years. They ...
Breaking Biology Technology:Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... Custom Solutions announced a processor modification in the popular ... to make it the most powerful augmentative, alternative communication ... that the new i7 processor is up to seven ... processing, longer battery life and more memory storage. ...
... Calif., Jan. 10, 2012 Accuray Incorporated ... company, announced today significant momentum in global adoption of ... TomoTherapy® System , solidifying the company,s footprint in the ... the company,s short- and long-term growth strategy, was ...
... 2012  Omeros Corporation (NASDAQ: OMER ) today reported ... of GPR25, GPR32, GPR80, GPR135 and MAS1, bringing the total ... to 23, representing 30 percent of the Class A orphan ... for drug development equals half of the total number of ...
Cached Biology Technology:Powerful AAC Device With Intel® i7 Processor Enables Natural Communication for Stroke, ALS and Autism Patients 2Accuray Surpasses 600 Installations Globally 2Accuray Surpasses 600 Installations Globally 3Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 2Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 3Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 4Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 5
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
One-step, microplate or cuvet, colorimetric, linear detection range 0.7 mg/dL to 35 mg/dL. Procedure: 5 min....
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
One-step, microplate or cuvet, colorimetric, detection range 0.1 mg/dL to 3 mg/dL. Procedure: 10 min....
Biology Products: