Navigation Links
Whole genome promoter mapping - Human Genome Project v2.0?

Investigators from the University California, San Diego (UCSD) Branch of the Ludwig Institute for Cancer Research (LICR) and NimbleGen Systems have developed an efficient method to identify thousands of regulatory sequences in the human genome, according to a study published today in Nature.

Genes are defined by their ability to generate a functional product. Thus the 'promoter' - a DNA sequence that controls when and where a gene product is generated - is the critical element that distinguishes a gene from 'junk DNA.' Using a set of NimbleGen's DNA microarrays that represent the entire human genome, the team was able to track critical proteins binding to each gene's promoter to identify 10,567 active promoters, 6 091 of which were previously unknown.

LICR's Dr. Bing Ren, the senior author of the study and a faculty member at the UCSD School of Medicine, says that although scientists have found most of the protein-coding genes in the human genome, their control sequences have been elusive until now. "Promoters are a type of genetic switch that turn gene expression on or off. If we know where the promoters are, we can study how the genetic switches work in a cell, and investigate their connection to human diseases," said Dr. Ren, who is also a member of the Rebecca and John Moores UCSD Cancer Center. He and his colleagues have made the data freely available on online public databases.

Dr. Robert Strausberg, Vice-President of Human Genomic Medicine at the J. Craig Venter Institute, says that this understanding is vital for determining the genetic causes of, and possible genomic solutions for, diseases such as cancer. "Medicine is increasingly turning towards the idea of using genetic markers for diagnosis and prognosis, or determining personalized therapies, so-called pharmacogenetics, but we don't know how these genes are regulated or even related to each other. The identification of such a large number of promoters means that we can begin to a nswer these sorts of questions."


'"/>

Source:Ludwig Institute for Cancer Research


Related biology news :

1. Whole genome fine map of rice completed
2. Whole-body MRI Takes Less Than 20 Min To Scan A Patients Entire Body For Cancer Spread To Bone
3. First Whole Genome Map of Genetic Variability in Parkinson’s Disease
4. Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm
5. Man and mouse share genome structures
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Highly adaptable genome in gut bacterium key to intestinal health
10. Fleshing out the genome
11. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... , Jan. 12, 2017  New research undertaken by ... of the future.  1,000 participants were simply asked which office ... which we may consider standard issue.  Insights on what ... were also gathered from futurists and industry leaders including ... James Canton .  Some of these ...
(Date:1/6/2017)...  SomaLogic announced today that it has agreed ... iCarbonX, the China -based company ... Health Ecosystem that can define each person,s ,digital ... behavioral and psychological data, the Internet and artificial ... will provide proteomics data and applications expertise to ...
(Date:12/22/2016)... -- As part of its longstanding mission to improve genetic literacy ... released its latest children,s book, titled The One ... topics of inheritance and variation of traits that are part ... school classrooms in the US. The book ... Killoran , whose previous book with 23andMe, You ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... PUNE, India , January 18, 2017 According to ... Application (Cancer Diagnosis, Neuroscience, Cytology, Infectious Disease), & End User (Molecular Diagnostic Laboratories, ... market is expected to reach USD 739.9 Million by 2021 from USD 557.1 ... Continue Reading ... MarketsandMarkets Logo ...
(Date:1/18/2017)... 2017 Applied BioMath ( www.appliedbiomath.com ), ... research and development, today announced that Dr. ... of Applied BioMath, will present at the next ... Meeting on Thursday January 19, 2017 at the ... MA.   Dr. Burke,s talk "Quantitative Modeling and Simulation ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... Executives 2017 in its continued commitment to the advancement of the clinical trials ... current issues related to clinical trial planning and management. , As executive ...
(Date:1/18/2017)... ... January 18, 2017 , ... Whitehouse Labs has furthered its ... Research, Inc. (AMRI), the scientific staff dedicated to Extractables / Leachables & Impurities ... growth in 2017. Extractable & Leachable evaluations have become increasingly more vital to ...
Breaking Biology Technology: