Navigation Links
Who gives stem cells their marching orders?

Researchers from the Swiss Institute for Experimental Cancer Research (ISREC) have shown that a single gene involved in embryonic development is responsible for two seemingly contradictory activities -- maintaining stem cells after the embryo has implanted in the mother's uterus, and later providing cues to direct their differentiation in a coordinated fashion when the time is ripe.

The development of an embryo from a few seemingly identical stem cells is a truly awesome feat of nature. As they bathe in a chemical soup they've manufactured themselves, stem cells react to subtle changes in chemical concentration, moving apart and taking on distinct identities. The million-dollar question: How do these cells ?all initially the same, and exposed to the same environment ?end up acting in such different ways, and in so orchestrated a manner? Understanding the choreography involved in this mysterious cellular signaling dance is crucial to our ability to coax stem cells to grow into specific tissues outside the body. And it is also important if we are to understand and perhaps correct what goes wrong when the chemical signaling system goes awry and stem cells become cancerous.

Research has shown that the chemical soup in the developing embryo contains a protein factor called Nodal, a powerful "master chef" that controls the activity of a whole host of important regulatory genes. The ISREC group showed that embryos already need Nodal when they attach to the wall of the uterus, to expand their pool of stem cells, and to let individual cells know where they are with respect to their neighbors. However, to carry out these tasks, the Nodal protein must be cleaved by specific enzymes. The enzymes act as a sort of regulatory switch, increasing the stem cells' production of Nodal and preventing them from differentiating too early. Using mice engineered to carry an altered form of the protein, the ISREC group showed that if this switch is blocked, Nodal has the opp
'"/>

Source:Ecole Polytechnique F茅d茅rale de Lausanne


Page: 1 2

Related biology news :

1. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
2. A little stress gives beneficial oomph! to immune system
3. Bionic arm gives amputee sense of touch
4. Gene thwarts some pathogens, gives access to others, could save crops
5. US woman gives birth to baby from worlds first frozen donor egg bank
6. Researcher gives hard thoughts on soft inheritance
7. Unique gene regulation gives chilly bugs survival advantage at bottom of the world
8. Thymus transplants gives hope to babies with fatal immune disease
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Who gives stem cells their marching orders

(Date:8/24/2015)... The consulting company Frost & Sullivan ... DERMALOG and its customized solutions and products for ... the Year Award". DERMALOG is particularly successful with a large ... -Cross reference: Picture is available at AP Images ( ... Thursday evening, in South Africa,s economic ...
(Date:8/20/2015)... ., Aug. 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market ... has joined The Smart Card Alliance and the EMV ... Alliance and the Smart Card Alliance Latin America (SCALA) ... industry peers and thought leaders promoting adoption of smart ...
(Date:8/17/2015)... OXFORD, Conn. , Aug. 17, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces its new sales campaign for Q4 2015. The ... winning marketing team consisting of Amplitude Marketing Group ( ... Amplitude Marketing Group is a leader in retail driven ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... -- A team of researchers from The Florida State ... will study the environmental and economic impacts of the ... on shrimping in the region, home to one of ... State will serve as the lead institution for the ...
... Oct. 30 SCM Microsystems, Inc. (Nasdaq: SCMM ) ... access, secure identity and secure exchange, announced today that its ... shares authorized during yesterday,s annual meeting of stockholders. ... 61 percent of SCM,s stockholders cast their votes and a ...
... The North Pacific Ocean is now commonly referred to ... size of the continental United States covered in plastic debris. ... forages throughout the North Pacific, is quickly becoming the poster ... due to their tendency to ingest large amounts of plastic. ...
Cached Biology News:FSU, Duke partner to study impact of Gulf's 'dead zone' on shrimp fishery 2FSU, Duke partner to study impact of Gulf's 'dead zone' on shrimp fishery 3SCM Microsystems Announces Results of Annual Meeting 2Dining out in an ocean of plastic: How foraging albatrosses put plastic on the menu 2
(Date:8/28/2015)... (PRWEB) , ... August 28, 2015 , ... Since the initial launch of FireflySci Inc. ... quirky humor and excellent customer service. Images such as the Fonz in a lab ... add some flavor to the humdrum spectroscopy field. , FireflySci is proud to ...
(Date:8/27/2015)... 2015  Neogen Corporation (NASDAQ: NEOG ) announced ... United Kingdom -based Lab M Holdings, a ... diagnostic systems. Lab M was founded ... of microbial testing and diagnostic products for the global ... currently sells into more than 70 countries worldwide, and ...
(Date:8/27/2015)... Calif. , Aug. 27, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... conferences in the month of September.  ... present at Rodman & Renshaw,s 17th Annual Global Investment ... PT at the St. Regis Hotel in ...
(Date:8/27/2015)... -- GlassesOff (OTCBB: GLSO), a visual neuroscience technology ... vision system, announced today a partnership with eight-time All-Star, ... to develop a new mobile app designed for professional ... on-court performance. Vision is the inception of every ... ball or blocking a pass. The critical impact vision speed ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3
... 28 Entest BioMedical, Inc., a newly formed wholly-owned ... Bulletin Board: BMSN) announced today the launch of its ... to focus on new stem cell research, including a ... traumatic brain injury (TBI) using autologous adipose-derived (fat) stem ...
... ("MedMira") (TSX Venture: MIR, NASDAQ: MMIRF ), ... solutions, announced today that VWR International, LLC (VWR) has ... Chester, Pennsylvania, VWR is a global laboratory supply and ... billion. , "The U.S. is an important market for ...
... Diagnostics scientists will present results of three studies revealing ... treatment of chronic myeloid leukemia (CML) and prostate cancer ... of Clinical Oncology (ASCO), scheduled for May 29 through ... DGX ) is the world,s leading provider ...
Cached Biology Technology:New Stem Cell Web Site to Focus on Traumatic Brain Injury, Spinal Cord Injury and Diabetes 2MedMira Strengthens North American Sales Channels, Adding VWR as Distributor for the United States 2Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 2Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 3Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 4Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting 5