Navigation Links
Who gives stem cells their marching orders?

Researchers from the Swiss Institute for Experimental Cancer Research (ISREC) have shown that a single gene involved in embryonic development is responsible for two seemingly contradictory activities -- maintaining stem cells after the embryo has implanted in the mother's uterus, and later providing cues to direct their differentiation in a coordinated fashion when the time is ripe.

The development of an embryo from a few seemingly identical stem cells is a truly awesome feat of nature. As they bathe in a chemical soup they've manufactured themselves, stem cells react to subtle changes in chemical concentration, moving apart and taking on distinct identities. The million-dollar question: How do these cells ?all initially the same, and exposed to the same environment ?end up acting in such different ways, and in so orchestrated a manner? Understanding the choreography involved in this mysterious cellular signaling dance is crucial to our ability to coax stem cells to grow into specific tissues outside the body. And it is also important if we are to understand and perhaps correct what goes wrong when the chemical signaling system goes awry and stem cells become cancerous.

Research has shown that the chemical soup in the developing embryo contains a protein factor called Nodal, a powerful "master chef" that controls the activity of a whole host of important regulatory genes. The ISREC group showed that embryos already need Nodal when they attach to the wall of the uterus, to expand their pool of stem cells, and to let individual cells know where they are with respect to their neighbors. However, to carry out these tasks, the Nodal protein must be cleaved by specific enzymes. The enzymes act as a sort of regulatory switch, increasing the stem cells' production of Nodal and preventing them from differentiating too early. Using mice engineered to carry an altered form of the protein, the ISREC group showed that if this switch is blocked, Nodal has the opp
'"/>

Source:Ecole Polytechnique F茅d茅rale de Lausanne


Page: 1 2

Related biology news :

1. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
2. A little stress gives beneficial oomph! to immune system
3. Bionic arm gives amputee sense of touch
4. Gene thwarts some pathogens, gives access to others, could save crops
5. US woman gives birth to baby from worlds first frozen donor egg bank
6. Researcher gives hard thoughts on soft inheritance
7. Unique gene regulation gives chilly bugs survival advantage at bottom of the world
8. Thymus transplants gives hope to babies with fatal immune disease
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Who gives stem cells their marching orders

(Date:4/16/2014)... Boulder, Colorado, USA - Geoscientists from the north-central U.S. ... 24-25 April to discuss new science, expand on existing ... of the region, with a special emphasis on applied ... talk at 7 p.m. on Thursday by Dr. Kirk ... Natural History. , The meeting is hosted by ...
(Date:4/16/2014)... or to conquer the world? Surprisingly, bacteria also ... in Munich have now shown how these organisms ... , The bacterium Bacillus subtilis is ... on agar surfaces by means of flagella. Alternatively, ... the bacteria proliferate most effectively in this stationary ...
(Date:4/15/2014)... UC Irvine neurobiologists have found that genetically modified neural ... brains of mice with the symptoms and pathology of ... journal Stem Cells Research and Therapy , and ... different mouse models. , Alzheimer,s disease, one of ... accumulation of the protein amyloid-beta in the brain in ...
Breaking Biology News(10 mins):Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4Theoretical biophysics: Adventurous bacteria 2UCI study finds modified stem cells offer potential pathway to treat Alzheimer's disease 2
... University researchers have discovered men with an unusual form ... men the same age who are cognitively normal. , ... disease in which people have trouble recalling and understanding ... themselves and understand speech. It differs from typical Alzheimer's ...
... study in Switzerland uses the tools of physics to ... time in the noisy cellular environment. , In ... Systems Biology, researchers from the Ecole Polytechnique Federale de ... on specific biochemical processes, reflecting recent association studies in ...
... A complex molecule and snake venom may provide researchers ... and developing new drugs. , Purdue University researchers bound ... identification tag that was delivered to specific proteins in ... to find a better way to ascertain the presence, ...
Cached Biology News:Vasectomy may put men at risk for type of dementia 2Vasectomy may put men at risk for type of dementia 3Keeping the body in sync -- The stability of cellular clocks 2Scientists use nanoparticle to discover disease-causing proteins 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... - Aegera Therapeutics announced today,the initiation of ... AEG33773, a,novel, orally bioavailable small molecule in ... The Phase I study will evaluate the ... a randomized,double blind, placebo controlled, single ascending ...
... that improve the, safety, effectiveness, and environmental impact of ... new denitrification ... products-, ... today that the company has closed the first,tranche of a $2.5 ...
... Litigation with US Labs, FT. MYERS, Fla., March ... its results for the fourth,quarter and full year of ... year included the following:, Fourth Quarter 2007 ... of 115% year-over-year from Q4 06 -- Avg. ...
Cached Biology Technology:Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain 2Environmental Operating Solutions Completes Initial Tranche of $2.5 Million Institutional Financing 2Environmental Operating Solutions Completes Initial Tranche of $2.5 Million Institutional Financing 3Environmental Operating Solutions Completes Initial Tranche of $2.5 Million Institutional Financing 4NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 2NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 3NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 4NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 5NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 6NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 7NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 8NeoGenomics Announces Results for the Fourth Quarter and Full Year FY 2007 9
... combines a single-channel sample processing head, an ... reagent dispenser all in one compact, affordable ... pipette tips, the Precision XS autoclavable and ... available for transferring larger volumes. Intuitive Precision ...
... races ever faster, you need a partner who ... our constant focus is on providing tools and ... our Biomek 3000 Laboratory Automation Workstation offers a ... is flexible. By integrating all aspects of liquid ...
... Rabbit Tissue Arrays contain 60 rabbit tissue samples ... contains 4 unstained slides and 1 hematoxylin and ... slide contains 15 different tissues from 4 rabbit ... per slide. Each tissue sample (or core) is ...
... with a wide variety of purity levels, scales ... Purity: IG(>50%), >70%, >80% and ... Sequence Length: Up to 120 residues ... D-amino acids, MAPs, KLH/BSA conjugation, and much more. ...
Biology Products: