Navigation Links
White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

y of injected cancer cells.

Cui and Willingham said the killing of the cancer cells in the cancer-resistant mouse requires three distinct steps:

  • First, the white blood cells migrate to the site of cancer cells after sensing their presence.
  • Second, they recognize unique properties on the surface of the cancer cells and closely surround those cells.
  • Third, a lethal dose of each white-blood-cell type's cancer-killing compound is delivered to the cancer cells. The killing molecule varies with the white-cell type.

The ordinary mice lack the first two steps.

The researchers found that the anti-tumor response involved white blood cells of the so-called innate immune system, which the body ordinarily employs to fight off bacteria, but which had not been thought to be effective in fighting off cancer. Instead, in these cancer-resistant mice, three white-blood-cell types of the innate immune system ?neutrophils, macrophages and natural killer cells ?all infiltrate the tumor site in a multi-pronged killing response.

"Each cell type had independent killing activity against the cancer cells," the authors said, using different molecules. Macrophages, for instance, have to be in physical contact with the cancer cell before unleashing its combination of killer molecules.

White blood cells from the cancer-resistant mice apparently have the same ability to attack a range of tumors when transplanted to ordinary mice.

Cui and Willingham also want to explore how this one process can detect a wide range of cancer cells of so many different types. The dogma of cancer fighters has always postulated that there are many different cancers. "This new research in mice suggests that there may be some things that most cancers have in common," said Willingham, a pathologist and head of the Section on Tumor Biology.


'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Great White shark evolution debate involves WSU Lake Campus geology professor
3. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Whiteflies and plant viruses can help each other to speed up biological invasion
7. Epstein-Barr virus protein crucial to its role in blood cancers
8. New insight into regulation of blood stem cells
9. Nano-bumps could help repair clogged blood vessels
10. First technology to remove prions that cause vCJD from blood launched
11. Breakthrough isolating embryo-quality stem cells from blood
Post Your Comments:
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) has ... Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, ... report to their offering. , ... be worn on the user,s body and have ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2Infinisource's NXG series sets new time clock standard 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... from the ARC Centre of Excellence for Coral Reef ... science to help solve some of the world,s biggest ... science fellow at the ARC CoECRS, holds a joint ... University in the USA. Dr Hicks says more ...
... WEST LAFAYETTE, Ind. Researchers have discovered a tube-shaped structure ... deliver its DNA during the infection process and then dissolves ... mechanism in the phiX174 virus, which attacks E. coli ... bacteria, is in a class of viruses that do not ...
... by scientists could help combat the spread of sleeping sickness. ... to communicate with one another could help limit the spread of ... could be designed to disrupt the flow of messages sent between ... disrupts sleep patterns is transmitted by the bite of the ...
Cached Biology News:Linking social science and ecology to solve the world's environmental problems 2Virus grows tube to insert DNA during infection then sheds it 2
(Date:2/26/2015)... VIEW, Calif. , Feb. 26, 2015  23andMe, ... of Kate Black as Privacy Officer and ... federal, and state privacy laws as well as health ... regulatory team, she will be responsible for reviewing, updating ... customers in the U.S. and abroad. She joined the ...
(Date:2/26/2015)... Feb. 26, 2015   Synageva BioPharma Corp. ... company developing therapeutic products for rare disorders, today ... 2015 goals, other key objectives, and financial guidance.  ... today at 4:30 p.m. EST to review the ... To participate in today,s call by telephone, please ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015 Protiviti ... the latest version of the Governance Portal , ... governance, risk and compliance (GRC) tasks across multiple business ... been updated to help customers better align their controls ... the Treadway Commission ) requirements. In response to client ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 The Movement ... demonstration to support life extension technologies and awareness. The ... Universal Coordinated Time, on March 21st 2015, in a ... , Eric Schulke, Founder of MILE, says, “Our ... with urgency. The Movement for Indefinite Life Extension is ...
Breaking Biology Technology:23andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3
... the Repair Stem Cell Institute says the viability of Embryonic Stem Cells ... a large lead in diseases being treated all over the world, that ... insurmountable problems, to catch up -- ever. , ... Bangkok (PRWEB) March ...
... DIEGO, March 12 Sangart, Inc., a privately held ... of oxygen therapeutics, today announced the receipt of approximately ... investment results from the exercise of warrants issued by ... initiated in 2007. The most recent investment brings ...
... Scientific Corporation (NYSE: BSX ) today announced ... outlook to stable from negative. In addition, Moody,s ... from Ba2 and its liquidity rating to SGL-2 from ... Moody,s said the revised rating outlook reflects: ...
Cached Biology Technology:Repair Stem Cell Institute Weighs in on Reversal of Embryonic Stem Cell Policy 2Sangart, Inc. Completes Series F Funding Round 2Moody's Raises Boston Scientific's Rating Outlook to Stable 2Moody's Raises Boston Scientific's Rating Outlook to Stable 3
... UltraPure Agarose and SYBR Safe DNA Gel Stain combo ... money versus buying these same products separately ... to ethidium bromide Eliminates ... resolves DNA and RNA fragments from 100 bp to ...
... The Sub-Plates are E.Coli glycerol stocks contained ... contains 50 cDNA clones with approximately 5,000 ... the a master plate well, the corresponding ... PCR to identify the positive well(s). Cells ...
... ml per liter of urine will give a ... BMD dipstick. ,Certification: The Donors are of ... to be NEGATIVE for HbsAg, HCV, HIV-1 & ... FDA methods. THIS MATERIAL IS SOLD FOR IN-VITRO ...
One controller two vessel system suitable for early stage of fermentation, and small scale, Application : cultivation of microorganisms and human or animal cells...
Biology Products: