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White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

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The researchers conclude that a major mechanism for regulation of neutrophil production involves secretion of IL-23 that is regulated by phagocytosis of apoptotic neutrophils. "The discovery of neutrophil-regulating cells suggests new ways to manipulate the inflammatory system and neutrophil production with possible relevance to the treatment of inflammatory diseases and the mitigation of chemotherapy-induced neutropenia," says Dr. Ley.

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Matthew A. Stark, Yuqing Huo, Tracy L. Burcin, Margaret A. Morris, Timothy S. Olson, and Klaus Ley: "Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17"


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Source:Cell Press


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