Navigation Links
White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells.

Human neutrophils are white blood cells that are constantly being produced in the bone marrow and released into the blood stream where they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes.

Although the specific mechanisms that regulate the proper ratios of neutrophil production and destruction are not well understood, it is known that the immune signaling molecules IL-17 and G-CSF stimulate neutrophil production. In addition, a newly discovered molecule called IL-23 that is produced by phagocytes has been shown to stimulate IL-17 production. Dr. Klaus Ley and colleagues from the University of Virginia investigated whether ingestion of apoptotic neutrophils influenced IL-23 production by phagocytes.

The researchers observed that the amount of IL-23 produced by phagocytes was reduced when phagocytes actively ingested apoptotic neutrophils. Interestingly, mice with abnormal neutrophils that lacked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 and IL-17 dro
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Great White shark evolution debate involves WSU Lake Campus geology professor
3. White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Whiteflies and plant viruses can help each other to speed up biological invasion
7. Placenta Is A Rich Source Of Blood Stem Cells
8. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
9. Mystery Blood Vessel Disorder Implicated In Mini Strokes
10. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
11. Young Blood Revives Aging Muscles, Stanford Researchers Find
Post Your Comments:
(Date:3/23/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), a ... announces its biometric payment technology, the Wocket® smart wallet, will ... 30 th . The new 30 ... markets. Gino Pereira , ... ad campaign following the recent initial shipment of Wocket smart ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Latin America . Annual estimates ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... of Pennsylvania School of Medicine have clarified the mechanism ... problems, in multiple animal models. The findings offer the ... bypass this issue, as reported in the April 13 ... Journal of Clinical Investigation. , "Although these results are ...
... at an alarming rate throughout Britain's coast and rivers, ... crab, brought to Britain during the last century in ... populations are not monitored and controlled, say the study's ... upon Tyne carried out the first comprehensive modelling of ...
... from the Max Planck Institite for Biophysical Chemistry ... magnetic resonance spectroscopy (solid-state NMR) with special protein ... toxins combine and change in structure. This work ... high blood pressure and many other diseases connected ...
Cached Biology News:Therapeutic prospects beyond Vioxx 2Therapeutic prospects beyond Vioxx 3Exotic crab poised for widespread UK invasion 2Exotic crab poised for widespread UK invasion 3Unraveling the mysteries of poison 2
(Date:3/27/2015)... YORK , March 27, 2015  Peter Walter ... Biomedical Science for his pioneering work on how proteins ... components of a regulatory mechanism that cells use to ... Dr. Walter is a professor of biochemistry at the ... groundwork for treating a range of human diseases related ...
(Date:3/27/2015)...  CASI Pharmaceuticals, Inc. (Nasdaq: CASI ), a ... of innovative therapeutics addressing cancer and other unmet medical ... on China , today reported financial ... 31, 2014.  The Company reported a ... for the three months ended December 31, 2014.  This ...
(Date:3/26/2015)... CA (PRWEB) March 26, 2015 PRC ... (CRO), announced today several management and executive appointments effective ... Chief Financial Officer (CFO) and member of the Board ... of Business Operations, and Sue Dowden will assume the ... co-founder and current Chief Operations Officer (COO), has been ...
(Date:3/26/2015)... March 26, 2015  BioNano Genomics, Inc., the leader ... Salyer as chief commercial officer. Salyer has more ... sales teams in life sciences. At BioNano, Salyer will ... a genome-mapping platform to assemble a comprehensive view of ... To date, 32 institutions located in the ...
Breaking Biology Technology:German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3
... , , COLUMBIA, Md., Sept. 8 ... that a panel of judges on the United States Court of ... appeal proceedings related to a patent infringement lawsuit between Martek and ... GmbH (collectively "Lonza"). The appeals involve Lonza,s U.S. sale and ...
... , PRINCETON, N.J., Sept. 8 Pharmasset, Inc. ... the Robert W. Baird & Co. Health Care Conference, Morgan ... Sciences Conference in New York, NY and the ThinkEquity G6 ... Schaefer Price, Pharmasset,s President and Chief Executive Officer, will ...
... , FORT LAUDERDALE, Fla., Sept. 8 ... in the region, launched an important joint event with the state,s ... gathered in Fort Lauderdale on August 27, to hear experts from ... of bio science and information technology. , , ...
Cached Biology Technology:Federal Circuit Rules in Martek's Favor in Appeal of Patent Infringement Case 2Federal Circuit Rules in Martek's Favor in Appeal of Patent Infringement Case 3Pharmasset to Present at Four Upcoming Investor Conferences 2Pharmasset to Present at Four Upcoming Investor Conferences 3South Florida Technology Alliance and BioFlorida Joint-Event Draws Big Names and Big Crowd 2South Florida Technology Alliance and BioFlorida Joint-Event Draws Big Names and Big Crowd 3
Human DC-SIGNR/CD209L MAb (Clone 120604)...
Human DPPII/QPP/DPP7 Biotinylated Affinity Purified PAb ENTREZ GeneID: 29952...
Human SorCS1 Affinity Purified Polyclonal Ab Protein Family: Neurotrophins...
Human Apolipoprotein B100 Affinity Purified Polyclonal Ab ENTREZ GeneID: 338...
Biology Products: