Navigation Links
White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells.

Human neutrophils are white blood cells that are constantly being produced in the bone marrow and released into the blood stream where they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes.

Although the specific mechanisms that regulate the proper ratios of neutrophil production and destruction are not well understood, it is known that the immune signaling molecules IL-17 and G-CSF stimulate neutrophil production. In addition, a newly discovered molecule called IL-23 that is produced by phagocytes has been shown to stimulate IL-17 production. Dr. Klaus Ley and colleagues from the University of Virginia investigated whether ingestion of apoptotic neutrophils influenced IL-23 production by phagocytes.

The researchers observed that the amount of IL-23 produced by phagocytes was reduced when phagocytes actively ingested apoptotic neutrophils. Interestingly, mice with abnormal neutrophils that lacked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 and IL-17 dro
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Great White shark evolution debate involves WSU Lake Campus geology professor
3. White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Whiteflies and plant viruses can help each other to speed up biological invasion
7. Placenta Is A Rich Source Of Blood Stem Cells
8. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
9. Mystery Blood Vessel Disorder Implicated In Mini Strokes
10. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
11. Young Blood Revives Aging Muscles, Stanford Researchers Find
Post Your Comments:
(Date:11/4/2014)... of Utah engineers developed the first room-temperature fuel cell ... without needing to ignite the fuel. These new fuel ... power and sensors. , A study of the new ... journal ACS Catalysis . , Fuel cells convert ... fuel and an oxygen-rich source such as air. If ...
(Date:11/4/2014)... only marketing directed at children on the interior ... that the majority of black, middle-income and rural ... , Authored by Arizona State University researcher Punam ... first to examine the use of child-directed marketing ... restaurants and its relationship to demographics. It adds ...
(Date:11/3/2014)... 3, 2014 Research and Markets has ... - Technologies, Markets and Companies" to their offering. ... and methods, which have already started to play an important ... is replacing the old fashioned bone marrow transplants. Role of ... bound to become a part of medical practice. ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... the Marine Biological Laboratory (MBL) in Woods Hole and ... the presence of the genetic material RNA in the ... proper cell division. , The findings, detailed June ... Proceedings of the National Academy of Sciences, present evidence ...
... cutting into their yields this year, said two Texas ... Station assistant research scientist and plant disease diagnostician, saw ... Plains Diagnostic Network lab this growing season, in addition ... the Panhandle. , Ninety-five percent of these samples were ...
... either preventing or promoting the cell death, a Queen's University ... principle that pharmacological inhibition of calpain may be used to ... such as in neuronal cells of Alzheimer's or Parkinson's patients, ... is clearly a very desirable outcome," says lead researcher Peter ...
Cached Biology News:RNA found in the cellular centrosome of surf clams 2More than drought affecting wheat yields 2Protein's role in regulating cell death sets direction for cancer research 2
(Date:11/21/2014)... 2014 Deep Research Report on Global ... report on the transformer market. The report provides ... industry chain structure as well as industry overview. ... China’s domestic market as well as global industry ... The report also covers information on policy, plans ...
(Date:11/21/2014)... SAN DIEGO , Nov. 20, 2014  Cytori Therapeutics ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com ... 4, 2014 TIME:    11:15 am PT / 2:15 ... this URL into your browser,s address bar: http://bit.ly/1B2KGaL ... time and receive event updates. This will ...
(Date:11/18/2014)... FL (PRWEB) November 17, 2014 ... point-of-care diagnostic tests – today announces its third ... and Prevention’s (CDC) Get Smart About Antibiotics Week ... Week is a national campaign designed to highlight ... health departments, and non-profit and for-profit partners to ...
(Date:11/18/2014)... CA (PRWEB) November 17, 2014 Athena Signature ... Salk , Dr. Beverly Emerson, a professor in the Regulatory ... genes. Her most recent discovery points to an “off switch” ... Emerson’s career and how her local research is making a ... present her findings and then join host Cheryl K. Goodman, ...
Breaking Biology Technology:International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3
... In light of an announcement made recently by Astellas ... confirmed that it had received a letter dated November 13, ... to acquire CV Therapeutics at a price of $16.00 per ... conditions. After careful deliberation, with the assistance of its ...
... quantum dots created by researchers at Canada,s National Institute ... a new level of control over individual electrons, a ... Composed of a single atom of silicon and ... the smallest quantum dots ever created. , ...
... Alfacell Corporation (OTC Bulletin Board: ACEL) today reported that ... Food and Drug Administration (FDA) to discuss the company,s ... rolling New Drug Application (NDA) for the treatment of ... meeting, the FDA provided guidance to the company recommending ...
Cached Biology Technology:CV Therapeutics Statement on Unsolicited Proposal From Astellas 2CV Therapeutics Statement on Unsolicited Proposal From Astellas 3Smallest ever quantum dots bring real world applications closer 2Alfacell Provides ONCONASE(R) NDA Submission Update 2Alfacell Provides ONCONASE(R) NDA Submission Update 3
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
Mouse monoclonal [CAT-1] to Chloramphenicol Acetyltransferase ( Abpromise for all tested applications)....
... Competent Yeast Cells are designed for use ... S. cerevisiae strain MaV203 contains deletions in ... use with GAL4-based two-hybrid systems. The strain ... selection of ProQuest bait and prey vectors. ...
Biology Products: