Navigation Links
White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells.

Human neutrophils are white blood cells that are constantly being produced in the bone marrow and released into the blood stream where they migrate out of the blood and roam the body in search of potentially harmful foreign substances. Neutrophils have a short lifespan and often die via a programmed cell death pathway called apoptosis within a matter of hours. Dying neutrophils are recognized and ingested by cells in the body tissues called phagocytes.

Although the specific mechanisms that regulate the proper ratios of neutrophil production and destruction are not well understood, it is known that the immune signaling molecules IL-17 and G-CSF stimulate neutrophil production. In addition, a newly discovered molecule called IL-23 that is produced by phagocytes has been shown to stimulate IL-17 production. Dr. Klaus Ley and colleagues from the University of Virginia investigated whether ingestion of apoptotic neutrophils influenced IL-23 production by phagocytes.

The researchers observed that the amount of IL-23 produced by phagocytes was reduced when phagocytes actively ingested apoptotic neutrophils. Interestingly, mice with abnormal neutrophils that lacked the ability to migrate into body tissues where they would have encountered phagocytes exhibited elevated IL-23 and IL-17 levels. When these mice received an infusion of normal neutrophils that were capable of migration, the levels of IL-23 and IL-17 dro
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Great White shark evolution debate involves WSU Lake Campus geology professor
3. White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells
4. Whitefly spreads emerging plant viruses
5. White blood cells in lung produce histamine seen in allergies
6. Whiteflies and plant viruses can help each other to speed up biological invasion
7. Placenta Is A Rich Source Of Blood Stem Cells
8. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
9. Mystery Blood Vessel Disorder Implicated In Mini Strokes
10. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
11. Young Blood Revives Aging Muscles, Stanford Researchers Find
Post Your Comments:
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ... Adding functional endpoints to toxicology studies has ...
(Date:12/10/2014)... RALEIGH, N.C. , Dec. 9, 2014  Valencell, ... announced it is seeing a staggering demand from its ... demand, the Company revealed, is not solely coming from ... industries as well. "A wearable is only ... a result, accuracy is the ultimate driver in long-term ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... 2010, a Cathay Pacific Airways plane was arriving in Hong ... was forced to make a hard landinginjuring dozens. The potential ... diesel fuel is increasing as biodiesel becomes more popular and ... store and transport the two types of fuels. ...
... , This news release is available in ... of things -- be it the grains of sand on a beach, ... use a part of the brain that is organized topographically, researchers have ... "numerosity" assessment are laid out in a shape that allows those most ...
... A team of researchers led by Charles D. Nichols, ... Center New Orleans, has successfully translated a new technology ... flies. This powerful genetic tool Designer Receptors ... selectively, rapidly, reversibly, and dose-dependently remotely control behaviors and ...
Cached Biology News:University of Tennessee professor and student develop device to detect biodiesel contamination 2Finally mapped: The brain region that distinguishes bits from bounty 2Finally mapped: The brain region that distinguishes bits from bounty 3LSUHSC researchers develop new system to better study behavior, cell function 2
(Date:12/19/2014)... contrast to traditional LED lights where the spectrum is ... LED technology to incorporate their spectra in a single ... in low proximity installations. The Valoya L-series offers high ... is up to four times longer than commonly used ... clearly higher when compared to traditional fluorescent or LED ...
(Date:12/19/2014)... December 18, 2014 With only 2 ... special on Sartorius Biohit products . The product ... pipettes, Picus Electronic Pipette Trade-in Program, and free pipette ... Safety officers around the world. They are ideal for ... features include:, ,     Full volume range of ...
(Date:12/19/2014)... 2014 Egenix, Inc. is pleased to announce that ... the Board, to succeed Donald Fresne ; Mr. Fresne ... as a member of the Board.  In recognition of the ... company over almost twenty years, the Board designated Mr. Fresne ... has established a Search Committee to find a suitable replacement ...
(Date:12/19/2014)... Dec. 18, 2014 Relmada Therapeutics, Inc. (OTCQB: ... treatment of chronic pain, announced the results of its ... "This was a transformational year in Relmada,s history and ... our company," said Sergio Traversa , chief executive ... executed on key financial, human resource and clinical development ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... This release is available in German . ... RFID tags (Radio Frequency Identification) are increasingly finding their way ... or goods and identify them automatically by radio frequency. The ... the label. Smart labels can be affixed to goods under ...
... , SANTA CRUZ, Calif., Nov. 24 Two more ... online job board and careers site for life science professionals. ... job board, joining 28 other major life science training Institutions. ... post-graduates in the life sciences. While there are hundreds of ...
... ... field remains the only one to show consistent growth during the U.S. recession. However, clinics ... actually cut medical personnel, instead of just administrators. , ... (Vocus) November 24, 2009 -- Health care employment continued growing in ...
Cached Biology Technology:Intelligence inside metal components 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4
... TempliPhi 100 Amplification Kit, 100 reactions. ... sequencing in 4-6 h.Generate microgram quantities ... of starting material.Use amplified DNA directly ... from bacterial or M13 liquid cultures, ...
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
For quantitative determination of Aldolase in Serum (an indicator of muscle damage). Ready-to-use liquid stable reagent. Formulated to eliminate interference from pyruvates. Application sheets are ...
This Universal 24" X 18" (61 X 45.7cm.) shaker platforms will accept any Thermo Forma shaker flask clip....
Biology Products: