Navigation Links
Where 'jumping genes' fear to tread

Scientists from the University of Queensland report in the journal Genome Research that large segments of the human genome are conspicuously devoid of ubiquitous mobile DNA elements called transposons. The locations of these regions are highly conserved among mammalian species and are enriched in genes crucial for the regulation of developmental processes.

Transposons, often called "jumping genes," are DNA sequences that have the capacity to move from one chromosomal site to another. More than three million copies of transposons have accumulated in humans throughout the course of evolution and now comprise an estimated 45% of the total DNA content in the human genome.

These mobile genetic elements are scattered throughout the human genome ?separated, on average, by only 500 base pairs. But Dr. John Mattick's laboratory at the University of Queensland, Australia, identified long tracks of genomic segments (greater than 10 kilobases in length) that lack transposable elements. His team identified 860 such sequences in humans, 993 in mice, and 559 in opossums. They named these segments TFRs, or transposon-free regions.

"Strikingly," says Mattick, "many TFRs in the human genome occur in the same position in the mouse and opossum genomes, despite the fact that transposons entered each lineage independently, after each species diverged from a common ancestor. It appears that many TFRs are evolutionarily conserved features that existed prior to ?and have been largely maintained since ?the divergence of eutherian mammals and marsupials approximately 170 million years ago."

The opossum was chosen for inclusion in the analysis because it is a marsupial that has a similar load of transposable elements compared to mice and humans but is evolutionarily distant from the two species. In contrast, the genomes of chicken and fish, which diverged from humans more than 300 million years ago, do not have a significant density of transposons.<
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2

Related biology news :

1. Where bacteria get their genes
2. Where Bacteria Get Their Genes
3. Where have all the butterflies gone?
4. Where we change our mind
5. Jumping genes contribute to the uniqueness of individual brains
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Where jumping genes fear tread

(Date:9/16/2014)... As open enrollment season approaches, U.S. employees will ... 2015 benefits. According to Aon Hewitt , the ... Aon plc (NYSE: AON ), employees ... in managing their health care decisions. This increased responsibility ... understand how they can make the most of the ...
(Date:9/15/2014)... 15, 2014) The so-called central dogma of ... long provided a simplified explanation for how genetic ... , In reality, of course, the process ... articulated nearly 60 years ago by Nobel Laureate ... For one, there are multiple types of RNA, ...
(Date:9/15/2014)... to a morphine regimen can result in better pain ... reduce the dosage of the opioid needed to be ... Indiana University. , The result could bring significant relief ... often felt in the arms and legs and associated ... unmet need for better treatments for neuropathic pain," said ...
Breaking Biology News(10 mins):Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 2Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 3Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 4Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 5Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 6Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 7Scientists discover RNA modifications in some unexpected places 2IU study: Combining epilepsy drug, morphine can result in less pain, lower opioid doses 2
... the United States are 32 times more likely to ... antibiotic, gentamicin, than others outside the poultry industry, according ... Johns Hopkins Bloomberg School of Public Health. While drug-resistant ... industrial broiler chicken environment, this is the first U.S. ...
... possum and a giant rat were recorded by scientists as ... and virtually unknown Lost World in the pristine wilderness of ... Indonesia Institute of Science (LIPI) scientists were accompanied by the ... its wildlife on an expedition to the Fojas in June ...
... the Neural Basis of Cognition (CNBC), a joint project ... have for the first time described a mechanism called ... the fly allowing stimuli to be more keenly sensed. ... the January 2008 issue of Nature Neuroscience, and available ...
Cached Biology News:Poultry workers at increased risk of carrying antibiotic-resistant E. coli 2Indonesia's 'Lost World' reveals more surprises 2Neuronal circuits able to rewire on the fly to sharpen senses 2
(Date:9/16/2014)... , September 16, 2014 BCC ... MARKET FOR STEM CELLS , the global market for ... billion by 2018, with a five-year compound annual growth ... witnessed in the Americas with growth projections of $2.2 ...      (Logo: http://photos.prnewswire.com/prnh/20140805/700528) , Unlike other ...
(Date:9/15/2014)... Cancer Immunotherapy Market : ... Therapies is a new market research report announced ... principal types of therapeutics that have become the ... immunotherapy (which is often called "immuno-oncology") in recent ... cellular immunotherapy. , The regular use of ...
(Date:9/15/2014)... made of carbon nanotubes is neat, but Rice University scientists ... nanotubes in new fibers created at Rice line up like ... chemist Angel Mart and his colleagues. , The tricky bit, ... in the journal ACS Nano , is keeping the ... fiber. , Left to their own devices, carbon nanotubes form ...
(Date:9/15/2014)... 15, 2014 Research and Markets has ... by Product, by Services, by Technology, by Application - Global ... Whole Exome Sequencing (WES) is next-generation technology used for ... exon. The exome, which is the total of all exons ... and is actually converted into proteins after translation. It is ...
Breaking Biology Technology:Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 2Global Market for Stem Cells to Reach $10.6 Billion in 2018; The Americas Growing at 13.9% CAGR 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 4Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 5Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3
... 4 Immtech Pharmaceuticals,Inc. (AMEX: IMM ) ... exclusive,license to BioAlliance Pharma SA (Euronext Paris - ... maleate (pafuramidine), in,Europe for the treatment of pneumocystis ... of Human African trypanosomiasis, also known as,African sleeping ...
... Israel, December 4 Healthcare,Technologies Ltd. (NASDAQ: ... its unaffiliated and voting shareholders (approximately 90%),voted in ... the meeting, the shareholders were asked to approve ... Inc, Mac,Bioventures Inc. and Gamida for Life B.V. ...
... Biotest Pharmaceuticals,Corporation, a leading developer of ... management team as part of the formal,completion ... (Nasdaq:,NABI) and the creation of Biotest Pharmaceuticals. ... Corporation Completes Acquisition,of Nabi Biologics Business Unit," ...
Cached Biology Technology:Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine 2Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine 3Immtech and BioAlliance Sign Licensing Agreement for Pafuramidine 4Healthcare Announced That an Overwhelming Majority of its Shareholders Approved the NexGen Biofuels Transaction 2Biotest Pharmaceuticals Corporation Announces Management Team 2Biotest Pharmaceuticals Corporation Announces Management Team 3