Navigation Links
When the going gets tough, slime molds start synthesizing

In times of plenty, the uni-cellular slime mold Dictyostelium discoideum leads a solitary life munching on bacteria littering the forest floor. But these simple creatures can perform heroic developmental acts: when the bacterial food supply dries up, Dictyostelium amebas band together with their neighbors and form a multi-cellular tower designed to save the children.

In a forthcoming study in Nature Chemical Biology, investigators at the Salk Institute for Biological Studies and the Medical Research Council of Molecular Biology (MRC) in Cambridge, England, use traditional and computer-based methods to show how Dictyostelium synthesizes the chemical signal called DIF-1, short for Differentiation Inducing Factor, required for this developmental transformation.

The collaboration, explains co-senior author Joe Noel, Ph.D, a Howard Hughes Medical Institute investigator at Salk, "shows the power of a combined approach involving bioinformatics, enzymology, structural biology and genetics to get at the heart of why organisms exploit natural chemicals to survive and prosper in challenging ecosystems."

When slime molds starve, they collectively form a multicellular slug-like creature that locomotes en masse to a warm spot. There, in response to the DIF-1 signal, slugs literally stand up and their cells metamorphose into either a column of stalk cells or next-generation spore cells, which perch atop the column waiting for food supplies to be restored.

Noel and Michael Austin, Ph.D., a postdoctoral fellow in Noel's lab and co-lead author of the study, have an ongoing interest in the biosynthesis of diverse plant and microbial polyketides by enzymes known as type III PKSs. Plants make polyketide natural products such as flavonoids and stilbenes for use as sunscreens, antibiotics, flower pigments, and anti-oxidants. Explains Austin, "Plant polyketides are also increasingly recognized to have significant benefits in the human diet as health-promo
'"/>

Source:Salk Institute


Page: 1 2 3 4

Related biology news :

1. Mayan stingless bee keeping: Going, going, gone?
2. The shape of things to come: Morphology database going global
3. Watch your step when the going gets rough
4. EGF receptor activation prevents microbes from going more than skin deep
5. Birds going extinct faster due to human activities
6. Ongoing collapse of coral reef shark populations
7. Bush, Cheney and Rumsfeld are now species of slime-mold beetles -- but strictly in homage
8. Jump-starting T Cells In Skin Cancer
9. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
10. Nanotechnology may find disease before it starts
11. Suicide risk does not increase when adults start using antidepressants, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: When the going gets tough slime molds start synthesizing

(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics ... to detect and prevent counterfeit microcircuits from entering into ... performing an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. ... while increasing their reliability throughout the supply chain. The ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" report ... One major trend upcoming in this ... biomedical applications. Chemical sensors help in recording of patient ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... their offering. One major trend emerging ... advances in technology, it is important to upgrade biometric ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... 11, 2010) Van Andel Research Institute (VARI) ... cells that line and protect the prostate in relation to ... that normal cells and cancer cells depend on different factors ... cancer cells without affecting normal cells when developing treatments. ...
... In its collective efforts to develop new drugs, the ... on the application of natural biological transformation processes. One ... microorganisms or cells in a bioreactor filled with a ... especially strict regulations, the conditions inside the bioreactor need ...
... When conditions become complicated, there is no choice but ... Some of them growing in mining areas have unusual strengths, ... and knowing how to deal with this. Based on this ... as medicinal herbs for contaminated soils. The current level ...
Cached Biology News:VAI researchers develop tool to help study prostate cancer 2Clean sampling from bioreactors 2Plants in mining areas can cure soil affected by contamination in very short time 2Plants in mining areas can cure soil affected by contamination in very short time 3
(Date:1/22/2015)... Denville, NJ (PRWEB) January 22, 2015 ... shearing technologies such as the Bioruptor® and complete ... semi-automation system for chromatin immunoprecipitation, alleviating the need ... reagents and controls needed for ChIP of histones ...
(Date:1/22/2015)...   Cypher Genomics, Inc., the leading genome ... SQNM ), the leading molecular diagnostics company, today ... prenatal tests (NIPT). Through this agreement, Sequenom will ... advance analysis of clinically-relevant fetal sub-chromosomal variants detected ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision ... tools to enable the broad use of genomic, imaging and ... the appointment of Michelle Munson , CEO of Aspera, ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... EntreMed, Inc.,(Nasdaq: ENMD ), a clinical-stage pharmaceutical ... inflammatory diseases, today,reported results for the three- and ... http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ), Revenues for the third ... comparable period a year ago. The Company,reported a ...
... TNS Recovery Complex(R) and APS Corrective Complex(TM)-, ... Improvements in Skin Elasticity-, CARLSBAD, Calif., ... recent launch of TNS Essential Serum(TM) a ... two,cutting-edge treatments, TNS Recovery Complex(R) and APS ...
... New labeling reinforces strong safety profile of Ranexa ... a.m. ET/5:00 a.m. PT -, PALO ALTO, ... CVTX ) announced today that the U.S. Food ... line indication for,Ranexa(R) (ranolazine extended-release tablets) for the ...
Cached Biology Technology:EntreMed Reports Third Quarter 2008 Financial Results 2EntreMed Reports Third Quarter 2008 Financial Results 3EntreMed Reports Third Quarter 2008 Financial Results 4EntreMed Reports Third Quarter 2008 Financial Results 5SkinMedica Launches TNS Essential Serum(TM) 2SkinMedica Launches TNS Essential Serum(TM) 3FDA Approves Ranexa(R) for First Line Anti Anginal Use and Adds New Claims for Reduction of Ventricular Arrhythmias, Bradycardia, New Atrial Fibrillation and HbA1c 2FDA Approves Ranexa(R) for First Line Anti Anginal Use and Adds New Claims for Reduction of Ventricular Arrhythmias, Bradycardia, New Atrial Fibrillation and HbA1c 3FDA Approves Ranexa(R) for First Line Anti Anginal Use and Adds New Claims for Reduction of Ventricular Arrhythmias, Bradycardia, New Atrial Fibrillation and HbA1c 4FDA Approves Ranexa(R) for First Line Anti Anginal Use and Adds New Claims for Reduction of Ventricular Arrhythmias, Bradycardia, New Atrial Fibrillation and HbA1c 5