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When it comes to gene transcription, random pauses aren’t quite so random, study finds

What causes pauses?

The study also addresses a long-standing question about enzyme memory: If an enzyme pauses at one DNA site, will it alter its behavior when it encounters the same sequence again? "It turns out that RNAP enzymes may have individual personalities, but no memories," Herbert explained. "That is, they exhibit a distinct behavior--they tend to pause more or less, but they don't seem to remember having paused."

Why does RNAP make these fitful stops and starts? "No one really knows what all these ubiquitous pauses are doing nor what really causes pauses. They may be there to act as some kind of a governor to control the speed of transcription," Block said. "The control of gene transcription is one of the most fundamental ways to regulate gene expression in general, and one way to control transcription is to control pausing. Cancer is an example of gene control gone amuck, so understanding the regulation of genes is critical to understanding cancer. Our results provide fresh insights into the control mechanisms that cells have for regulating the genes they express."


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Source:Stanford University


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