Navigation Links
When good DNA goes bad

When otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma, according to a study by researchers at The University of Texas M. D. Anderson Cancer Center.

The study, issued in advance of the Feb. 21 edition of the Proceedings of the National Academy of Sciences, demonstrates for the first time that the oddly shaped DNA can cause DNA breaks in mammalian cells.

Interestingly, these sequences prone to forming Z-DNA are often found in genetic "hot spots," areas of DNA known to be prone to the genetic rearrangements associated with cancer. About 90 percent of patients with Burkitt's lymphoma, for example, have DNA breaks that map to regions with the potential to form these odd DNA structures.

"Our study shows that DNA itself can act as a mutagen, resulting in genetic instability," says Karen Vasquez, Ph.D., lead author of the study and assistant professor of carcinogenesis at M. D. Anderson's Science Park Research Division, Smithville, Texas. "The discovery opens up a new field of inquiry into the role of DNA shape in genomic instability and cancer."

Imagine untwisting the DNA ladder and then winding it up the other way. The result is a twisted mess with segments jutting out left and right, and the all important base pairs that hold the DNA code zigzagging in a jagged zipper shape. Scientists call this left-hand twist Z-DNA. This is a far cry from the graceful right-hand twisted helix that has become an iconic symbol of biology. It just doesn't look right, and it doesn't act right either, according to Vasquez. This awkward shape puts strain on the DNA, and as Vasquez and her colleagues show, can cause the DNA molecule to break completely apart.

Scientists have known for many years that DNA can take shapes other than the typical twisted ladder form, but they weren't sure how often these alternate shapes occur inside cells. Resear
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. New insights into how Huntingtons disease attacks the brain
2. New insights into the software of life
3. Marsupial genome reveals insights into mammalian evolution
4. Frog’s ear canal may provide insights for understanding human hearing loss
5. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
6. AIDS vaccine research offers new insights on survival
7. Mutant mouse provides insights into breast cancer
8. From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
9. New insights into autoimmunity and depression
10. Gene keeps neural cells on correct developmental path
11. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: When good DNA goes bad

(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
(Date:5/8/2015)... -- Synaptics Inc. (NASDAQ: SYNA ), the leading developer ... executive management team will present at the following investor events: ... Conference Date: May 18, 2015 Time: 10:40am ET ... Cowen and Company Technology, Media & Telecom ... New York Palace Hotel, New York, NY ...
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... Athene Donald has won the Science and Technology award ... honor to Professor Donald, Glamour magazine praised her as a ... real path for herself in the male-dominated world of physics." ... Physics at the University of Cambridge in the United Kingdom ...
... CAA researcher at Charles Drew University of Medicine and Science ... a promising, natural therapy for cancer. Dr. Mamdooh Ghoneum ... on "Cell Death Mechanism," sponsored by the American Association for ... San Diego. "The central focus of the meeting ...
... RIVERSIDE, Calif. Stem cell research at the University of ... establishment of a new Stem Cell Core Facility (SCCF) ... doing stem cell research that ordinarily would not be available ... Noel Keen Hall, had its grand opening on Friday, Jan. ...
Cached Biology News:Charles Drew cancer studies with yeast yield excellent results 2UC Riverside's new state-of-the-art technology to accelerate stem cell research 2
(Date:5/22/2015)... (PRWEB) May 22, 2015 Knowledgent ... white paper that explores the potential of big data ... white paper was developed to help life sciences and ... leverage data to gain critical business insights. , The ... amounts of data driven by patient profiling, compliance and ...
(Date:5/21/2015)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... commercializes proprietary technologies and products for advanced microarray diagnostics, ... second fiscal quarter ended March 31, 2015. ... business with our existing customers and to develop new ... of SQI. "The delivery of a fully automated sqidlite™ ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Specialty ... audit and been admitted to BPA Worldwide as ... Worldwide will track audience data for Specialty Pharmacy ... , “By becoming a member of BPA ... to providing our clients with the most reliable, ...
(Date:5/21/2015)... -- Prima Biomed Ltd. (NASDAQ: PBMD ) a globally ... leader in the development of immunotherapeutic products for the ... data from the Phase II CAN-003 ovarian cancer clinical ... meaningful improvement in Overall Survival ("OS") over standard of ... the group of second remission patients (n=20), the median ...
Breaking Biology Technology:New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Specialty Pharmacy Times Joins BPA Worldwide 2Correction Continues after Big Move - BrokerBank Securities, Inc. 2
... Feb. 1, 2011 MediVet-America today announced the ... to provide technical support for in-clinic animal stem ... Processing, Cryogenic Banking Services, Autologous Conditional Serum Processing, ... treatments. MediVet-America, the leading developer of ...
... Corporation (Nasdaq: PRXL ) today announced its ... 2010. For the three months ended December ... to $304.4 million, compared with $284.7 million in the ... exchange movements of $4.8 million, revenue increased 8.6%.  As ...
... Jan. 31, 2011 Netsmart Technologies, Inc., a leading ... services organizations, today announced that Paul Black has joined ... healthcare and software technology expertise to the board as ... solutions. Black served with publicly-traded Cerner ...
Cached Biology Technology:MediVet-America, Leading Animal Stem Cell Developer, Launches MediVet Lab Services 2PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 2PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 3PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 4PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 5PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 6PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 7PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 8PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 9PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 10PAREXEL Reports Second Quarter Fiscal Year 2011 Financial Results 11Former Cerner Chief Operating Officer Joins Netsmart Technologies Board of Directors 2Former Cerner Chief Operating Officer Joins Netsmart Technologies Board of Directors 3
... Digest Medium (TSB), USP is a highly ... general laboratory use. Due to the inclusion ... medium will support growth of many fastidious ... , Product conforms to United States Pharmacopeia ...
... Array (MSTA) slides were designed to study protein ... multiple species. Tissue slices from three different ... can then be treated as a single histological ... situ hybridization. This format allows a ...
... Xcell eukaryotic system, 100 to ... used for electroporation of mammalian ... main unit, CE module for ... square-wave pulses, ShockPod shocking chamber, ...
... WinMelt software is used ... of any DNA sequence up ... in optimizing placement of primers ... detection by denaturing gradient gel ...
Biology Products: