Navigation Links
What's next for gene therapy? Plastic

Gene therapy depends upon foreign DNA, even viruses, to deliver genes, therapeutic proteins, or medicine to cells within the body. Many scientists are looking for better chaperones across the cell membrane. Virginia Tech researchers think polymer molecules can be created to do the job.

The research will be presented at the 232nd national meeting of the American Chemical Society in San Francisco September 10-14, 2006.

"We are applying our fundamental knowledge in polymer science to gene transfer agents," said Tim Long, professor of chemistry in the College of Science at Virginia Tech. "We are trying to understand how the structure of the chaperone impacts the efficiency of its ability to transfer DNA across the cell membrane."

Entire texts have been devoted to the subject, Long said. "But the researchers are usually biologists. Polymer scientists can bring a unique perspective that I think will lead to new advances."

Long's graduate student, John M. Layman of Richmond, Va., will share information regarding star-shaped, or highly-branched, molecules, which are extremely effective at transfection. Long's group has demonstrated that the topology of these particular polymers can be changed. "We can control the molecular shape and number of functional end groups," said Long. "We think that topology is important because it can influence the strength of the interaction with DNA and permit efficient release of the DNA for protein synthesis."

Layman will deliver the talk, "Influence of macromolecular architecture on nucleic acid transfection (POLY 611)," at 4 p.m., Wednesday, Sept. 13, in the Marriott Salon 14/15 as part of the International Biorelated Polymers Symposium. Authors are Layman, Anjali A. Hirani of the Virginia Tech-Wake Forest School of Biomedical Engineering (VT-WF SBES), Joseph M. Pickel and Phillip F. Britt of the Oak Ridge National Laboratory Chemical Sciences Division, Yong Woo Lee at VT-WF SBES, and Long.

"The paper defines a new paradigm for research," said Long. Layman, whose bachelor of science degree is from Virginia Commonwealth University in chemical engineering, "typifies the way we are going to educate students in the future," Long said. "He is an engineer working in chemistry on gene therapy. He collaborates with researchers in the Virginia Tech-Wake Forest School of Biomedical Engineering and Oak Ridge National Laboratory.

Source:Virginia Tech

Related biology news :

1. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
2. Whats shaped like a pear and has 2 genomes? Check the pond
3. Whats nature worth? New computer models tell all
4. Whats in the water? Estrogenic activity documented in fish caught in Pittsburghs rivers

Post Your Comments:

(Date:11/9/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), the ... entry into the automotive market with a comprehensive and ... of consumer electronics human interface innovation. Synaptics, industry-leading touch ... the automotive industry and will be implemented in numerous ... , Japan , and ...
(Date:10/29/2015)... 29, 2015  The J. Craig Venter Institute (JCVI) ... Synthesis and Biosecurity: Lessons Learned and Options for the ... and Human Services guidance for synthetic biology providers has ... --> --> Synthetic biology ... potential to pose unique biosecurity threats. It now is ...
(Date:10/29/2015)... , October 29, 2015 ... authentication company focused on the growing mobile commerce ... announces that StackCommerce, a leading marketplace to discover ... the Wocket® smart wallet on StackSocial for this ... ("NXT-ID" or the "Company"), a biometric authentication company ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... -- Symic, a clinical-stage biotherapeutics company developing multiple compounds that ... that it has secured $25 million in a Series ... lead candidates SB-030 and SB-061. The financing was led ... existing major investors, as well as several new investors. ... Symic to over $43 million since being founded in ...
(Date:12/1/2015)... Austin, Texas (PRWEB) , ... December 01, 2015 , ... ... In his new post, VerMilyea will oversee all IVF lab procedures as ... analysis and fertility preservation. , “We traveled 7,305 miles to Auckland, New Zealand to ...
(Date:11/30/2015)... ... 2015 , ... Global Stem Cells Group today ... Santiago Marriott. The Global Stem Cells Group GMP facility is equipped with the ... medical researchers and practitioners, experienced in administering stem cell protocols using highly manipulated ...
(Date:11/30/2015)... Partnership includes an MPP licen ... niversity , s Solid Drug Nanoparticle (SDN) Technology ... up through cost cuts of priority ... licensees based anywhere in the world will have the right to make, use and ... , where licensees based anywhere in the world will have the right to make, ...
Breaking Biology Technology: