Navigation Links
What's next for gene therapy? Plastic

Gene therapy depends upon foreign DNA, even viruses, to deliver genes, therapeutic proteins, or medicine to cells within the body. Many scientists are looking for better chaperones across the cell membrane. Virginia Tech researchers think polymer molecules can be created to do the job.

The research will be presented at the 232nd national meeting of the American Chemical Society in San Francisco September 10-14, 2006.

"We are applying our fundamental knowledge in polymer science to gene transfer agents," said Tim Long, professor of chemistry in the College of Science at Virginia Tech. "We are trying to understand how the structure of the chaperone impacts the efficiency of its ability to transfer DNA across the cell membrane."

Entire texts have been devoted to the subject, Long said. "But the researchers are usually biologists. Polymer scientists can bring a unique perspective that I think will lead to new advances."

Long's graduate student, John M. Layman of Richmond, Va., will share information regarding star-shaped, or highly-branched, molecules, which are extremely effective at transfection. Long's group has demonstrated that the topology of these particular polymers can be changed. "We can control the molecular shape and number of functional end groups," said Long. "We think that topology is important because it can influence the strength of the interaction with DNA and permit efficient release of the DNA for protein synthesis."

Layman will deliver the talk, "Influence of macromolecular architecture on nucleic acid transfection (POLY 611)," at 4 p.m., Wednesday, Sept. 13, in the Marriott Salon 14/15 as part of the International Biorelated Polymers Symposium. Authors are Layman, Anjali A. Hirani of the Virginia Tech-Wake Forest School of Biomedical Engineering (VT-WF SBES), Joseph M. Pickel and Phillip F. Britt of the Oak Ridge National Laboratory Chemical Sciences Division, Yong Woo Lee at VT-WF SBES, and Long.


'"/>

Source:Virginia Tech


Page: 1 2

Related biology news :

1. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
2. Whats shaped like a pear and has 2 genomes? Check the pond
3. Whats nature worth? New computer models tell all
4. Whats in the water? Estrogenic activity documented in fish caught in Pittsburghs rivers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: What next for gene therapy Plastic

(Date:3/26/2015)... The Granite Club, Canada,s ... announced it has implemented a state-of-the-art access and security ... and staff, while restricting access to authorized users only. ... IMID Access system because it has the perfect combination ... in addition to unparalleled security," said James DiRenzo ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... Irvines Henry Samueli School of Engineering has received ... to establish a center focused on researching and ... The Edwards Lifesciences Center for Advanced Cardiovascular Technology ... members and experts by incorporating both undergraduate and ...
... A chorus of signals . . . ... microscopy, moves the field towards probing energy transformation at ... measure the cantilevers movements over the surface of a ... and detects response over a continuous band of frequencies, ...
... and children receiving artificial heart-valve replacements face several repeat ... become too small and must be traded for bigger ... a solution: living, growing valves created in the lab ... issue of Circulation published September 11, they describe making ...
Cached Biology News:UCI receives $5M from Edwards Lifesciences 2Story tips from the US Department of Energy's Oak Ridge National Laboratory, September 2007 2Story tips from the US Department of Energy's Oak Ridge National Laboratory, September 2007 3A step toward tissue-engineered heart structures for children 2
(Date:3/25/2015)... , March 25, 2015  The Technology Association ... leading association dedicated to the promotion and economic advancement ... announced Streamline Health as one of its Top 40 ... TAG will recognize this prestigious group at the 2015 ... the Cobb Galleria Centre. TAG,S Top 40 ...
(Date:3/25/2015)... -- FDNA®, the pioneer in computer-aided dysmorphology ... allowing geneticists around the globe to access Facial ... devices. Face2Gene® facilitates detection of facial dysmorphic features and ... up-to-date genetic references. The date of the release coincides ... Salt Lake City, UT , where ...
(Date:3/25/2015)... NEW YORK , March 25, 2015   ... highly specialized targeted investor and business development conferences exclusively ... that it is launching the Biotech CEO Summit. ... think-tank style meeting that brings together biotech industry leaders ... responsible growth and innovation while reaping the rewards of ...
(Date:3/25/2015)... DNA Spectrum , a leading consumer ... product earlier this year. This consumer offering is designed ... currently stands. It does so through analysis of customers’ ... affect physical fitness. Once this analysis is completed, myDNA ... effects with the client's body profile and the latest ...
Breaking Biology Technology:Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 3Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 4FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2Biotech CEO Summit to Bring Key Biotech Leaders Together in Industry Brain Trust 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 3DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 4
... , , , EMERYVILLE, ... company, announced today that new research data will be delivered ... on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, CA ... a multi-institutional collaborative in vitro study of Adamas, ...
... , , ... MASI ), the inventor of Pulse CO-Oximetry(TM) and ... its Radical-7 and Rad-57 Pulse CO-Oximeters have achieved Airworthiness ... certification is a fundamental milestone that allows the U.S. ...
... LAUSANNE, Switzerland, September 3 Debiopharm Group, SA,(Debiopharm), ... focus on the development of prescription drugs that ... Sciences Award, to Dr Lluis,Quintana-Murci from the Institut ... the emerging field of evolutionary genetics of,infection. Funded ...
Cached Biology Technology:Adamas Pharmaceuticals to Present Data on Triple Combination Antiviral Drug Therapy for Drug-Resistant Influenza at 2009 ICAAC Annual Meeting 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 4The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 2The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 3
... LC Sciences provides a comprehensive epitope ... microarrays synthesized on Paraflo microfluidic chips ... biosensor development. This comprehensive service includes ... assays using sample(s) provided by you, ...
... ,Schistosomal glutathione-S-transferase (GST) is commonly ... proteins in E. coli (1). The GSTTag ... production and in some cases the solubility ... a soluble, properly folded form, GSTTag fusion ...
... The Bio-Stack is compatible with ... systems. Speed, ease of use and ... routine microplate process. When used with ... reagent dispenser, the Bio-Stacks small footprint ...
... and versatile automated strip washer which can ... manifold. This breakthrough design allows for independent ... for overfill washing and overflow protection in ... of fitting dispense and aspirate tubes into ...
Biology Products: