Navigation Links
What controls stickiness of 'smart' chromosomal glue

i, which also appeared in Nature, demonstrated that cohesins can be retained at the centromeres during meiosis by enzymes that remove phosphates from the cohesins, counteracting the effects of phosphorylation.

Amon and her colleagues found that phosphorylation was not the only process essential for cohesion removal. Recombination ?an exchange of DNA between chromosomes that promotes genetic diversity ?was also needed for the initial removal of cohesin from the chromosome arms, they found.

In meiotic recombination, after each member of a chromosome pair has replicated to produce identical sister chromotids in the initial stage of meiosis, the chromosomes exchange arm segments. Only after this exchange, or recombination, do the cells proceed to the second stage of meiosis -- dividing without chromosome replication to produce haploid sperm or egg cells. Recombination is essential for cohesins to get removed from chromosome arms before they are removed from centromeres, Amon said.

"For a long time, people did not think that recombination played any role in establishing the step-wise cohesin loss pattern," she said. "But our experiments showed that recombination is absolutely essential to remove cohesins from chromosome arms during the initial meiotic stages, and if you don't have recombination that does not happen properly."

Amon also said that the Nature paper represents a significant advance in understanding the enzyme that phosphorylates Rec8, named Polo kinase, because it more accurately identified the specific sites on the Rec8 subunit that Polo phosphorylates. Firm identification of such sites will enable more precise studies of the mechanism of function of Rec8, and will also enable scientists to identify other protein targets of Polo kinase, she said.

Amon emphasized that the discovery of the importance of phosphorylation and recombination is only the beginning of understanding the intricate, critical process
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
2. Master gene controls healing of skin in fruit flies and mammals
3. Scientists find that protein controls aging by controlling insulin
4. MicroRNA tweaks protein that controls early heart development
5. Scientists discover gene that controls speed of tuberculosis development
6. Gene controls whether fear is a factor
7. Salk researchers make fast strides towards understanding how our body controls walking
8. Robotic joystick reveals how brain controls movement
9. Molecular on/off switch controls immune defenses against viruses
10. Pair of microRNA molecules controls major oncogene in most common leukemia
11. Fast and slow -- How the spinal cord controls the speed of movement
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: What controls stickiness smart chromosomal glue

(Date:7/9/2014)... on the verge of an economy driven by methane, the ... and is undergoing a production boom. It has poised the ... is casting serious doubts over just how climate-friendly it is, ... (C&EN), the weekly news magazine of the American Chemical ... at C&EN, explains that when burned as a fuel to ...
(Date:7/9/2014)... Can thyroid hormone protect neuronal function and increase ... Ailing Fu and her team, School of Pharmaceutical ... in which aged mice were administered with low ... showed that the aged rats exhibited an obvious ... rate from 60% to 93%. The underlying mechanism ...
(Date:7/9/2014)... They are amongst the most numerous inhabitants of the ... . Not visible to the naked eye, when they ... sized patches, they are even visible on satellite images. ... responsible for approximately half of the global photosynthesis output," ... University Jena (Germany). In the process the greenhouse gas ...
Breaking Biology News(10 mins):Short circuit in the food web 2
... of scientists, including University of Colorado School of Medicine ... disease related to an inability to process Vitamin B12. ... "Some people with rare inherited conditions cannot process vitamin ... a geneticist and senior author of a paper about ...
... key role in preserving biological diversity. A new study carried ... (SLU), among others, indicates that if the world,s religious leaders ... positioned to do so. Our study investigates how ... they overlap areas that are important for global biological diversity, ...
... $4.5 million over the next five years for a ... detecting disorders and conditions can and should become a ... one of four projects launched today by the National ... providing genetic sequencing as part of, or instead of, ...
Cached Biology News:Peering into genetic defects, CU scientists discover a new metabolic disease 2Peering into genetic defects, CU scientists discover a new metabolic disease 3Religious leaders can be key to biological diversity 2UCSF receives $4.5M to study value of gene sequencing in newborns 2UCSF receives $4.5M to study value of gene sequencing in newborns 3UCSF receives $4.5M to study value of gene sequencing in newborns 4
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
(Date:1/14/2014)... CA (PRWEB) January 14, 2014 Histogen, ... the products of cells grown under simulated embryonic conditions, ... license agreement with Suneva Medical, Inc. for physician-dispensed aesthetic ... , This agreement is an amendment to ...
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... 14, 2014 iLab Solutions, the leader in ... new Director of Product Strategy. In this role, Michelle will ... sub-teams to guide in the development of iLab products. Her ... maximum possible benefit to the scientific community by offering the ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... Inc., a developer of innovative therapeutics for diseases ... results for the company,s lead product candidate, OTO-104, ... demonstrated that a single intratympanic (IT) injection of ... corticosteroid dexamethasone, provided significant protection against both noise-induced ...
... Feb. 22, 2011 Jennerex, Inc. (San ... appointment of James M. Burke, M.D. to the newly-created ... be responsible for all global clinical research activities related ... has been working with Jennerex in an advisory capacity ...
... KONG, Feb. 22, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation ... first and largest cord blood banking operator in China, today ... was held on February 18, 2011, in Hong Kong. ... Albert Chen and Mark Chen to serve on the Board ...
Cached Biology Technology:Otonomy's OTO-104 Demonstrates Hearing Loss Protection and Hearing Recovery in Preclinical Studies 2Otonomy's OTO-104 Demonstrates Hearing Loss Protection and Hearing Recovery in Preclinical Studies 3Jennerex Appoints James M. Burke, M.D. Vice President, Clinical Research 2China Cord Blood Corporation Announces Results of 2010 Annual General Meeting 2
... The APO-BRDU Kit is a two ... and total cellular DNA to detect apoptotic ... the instructions and reagents required for measuring ... control cells for assessing reagent performance; washing, ...
... CHEMICON APO-BRDU Kit is a ... breaks and total cellular DNA to detect ... kit contains the instructions and reagents required ... and negative control cells for assessing reagent ...
... with temperature probe, 100-120 and 220-240 V, supports ... and 400 W. The temperature probe is used ... degrees C during electrophoresis. Built-in infrared capability allows ... are provided. Dimensions are 27.5 x 34 x ...
The Trans-Blot Plus gel and cassette assembly tray is used to hold the Trans-Blot Plus gel holder cassette, buffer, and other materials for the gel and membrane sandwich during their assembly....
Biology Products: