Navigation Links
What controls stickiness of 'smart' chromosomal glue

Researchers have a new understanding of the process cells use to ensure that sperm and eggs begin life with exactly one copy of each chromosome ?a process that must be exquisitely regulated to prevent problems such as miscarriages and mental retardation. The new work reveals how gluelike protein complexes release pairs of chromosomes at precisely the moment of meiosis ?the specialized cell division process that produces sperm and eggs ?enabling them to separate properly.

The researchers, led by Howard Hughes Medical Institute investigator Angelika Amon, published their findings online May 3, 2006, in the journal Nature. Amon and her colleagues are at the Massachusetts Institute of Technology.

Most cells in the human body ?all those other than sperm and eggs ?contain 23 pairs of chromosomes. These cells divide through mitosis, a process that creates daughter cells with the same complement of chromosome pairs as the parent. Sperm and egg cells, on the other hand, must contain only half the chromosomes of their parent cells, so that the normal chromosome number will be restored when the sperm and egg unite during fertilization. To achieve this, they are produced through meiosis.

Gluelike protein complexes called cohesins, which hold the members of a chromosome pair together until just the right moment during cell division, are central to both processes. Bound together by cohesins, chromosome pairs must organize themselves in preparation for cell division before they can be released.

According to Amon, a deeper basic knowledge of the mechanism of cohesin loss during meiosis could ultimately improve understanding of the origins of miscarriages and mental retardation due to mis-segregation of chromosomes.

"We first need to understand the key regulatory players and the molecular mechanisms that cause chromosomes to segregate in this very unusual way during meiosis," she said. "Once we have a good enough understanding, then we c
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
2. Master gene controls healing of skin in fruit flies and mammals
3. Scientists find that protein controls aging by controlling insulin
4. MicroRNA tweaks protein that controls early heart development
5. Scientists discover gene that controls speed of tuberculosis development
6. Gene controls whether fear is a factor
7. Salk researchers make fast strides towards understanding how our body controls walking
8. Robotic joystick reveals how brain controls movement
9. Molecular on/off switch controls immune defenses against viruses
10. Pair of microRNA molecules controls major oncogene in most common leukemia
11. Fast and slow -- How the spinal cord controls the speed of movement
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: What controls stickiness smart chromosomal glue

(Date:10/17/2014)... release is available in German . ... a very few drugs. When treating overdoses, doctors are often ... especially difficult if there is a combination of drugs involved. ... and accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux ... to find an answer to this question. "The task was ...
(Date:10/16/2014)... have challenged conventional thinking on how the bowel lining ... for how bowel cancer starts. , The researchers produced ... regenerating the ,crypts, that are a feature of the ... in bowel cancer development, a controversial finding as scientists ... Using 3D imaging technologies, Dr Chin Wee Tan and ...
(Date:10/16/2014)... 16, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... including Wocket™, the Smart Wallet, at the 13 th ... a leading global conference on the intersection of technology ... Mark Anderson , founder and publisher of the Strategic ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3Cryptic clues drive new theory of bowel cancer development 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... in some regions and increasing global demand for high ... water globally. This was the main conclusion of a ... Education. The special report follows a strategic workshop ... rules of international trade" held on 25th - 26th ...
... at the Genome Institute of Singapore (GIS) have, for ... comes with a guarantee on its reliability when reconstructing ... streamlined process for reconstructing and studying genomic sequences. ... of Computational and Mathematical Biology at the GIS, was ...
... fish have a greater capacity to cope with rising sea ... The discovery, by researchers at the ARC Centre of ... sheds a ray of hope amid the rising concern over ... levels of global warming expected to occur by the end ...
Cached Biology News:Experts call on governments, industries and the water and trade research communities 2Researchers at GIS develop systematic approach for accurate DNA sequence reconstruction 2When the heat's on, fish can cope 2When the heat's on, fish can cope 3
(Date:10/22/2014)... SC (PRWEB) October 22, 2014 ... of its cardiovascular pharmacogenetics menu, which enables healthcare ... outcomes. With PCLS’s evidence-based results, healthcare providers ... and optimize their therapy, while minimizing risks for ... the U.S., according to the FDA [1] more ...
(Date:10/22/2014)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... Oral Amphotericin B program.  The company recently announced ... work involving samples from HIV/AIDS patients exposed to ... clinical studies and regulatory filings to move forward ... approximately $700,000 of funding and technological advice from ...
(Date:10/22/2014)... and HONG KONG , Oct. ... disease therapeutics enterprise, announced today that rare disease expert ... as vice president, research. Dr. McKew brings more than ... leadership positions at the National Institutes of Health, Wyeth ... by Wyeth). Dr. McKew will lead aTyr,s efforts to expand ...
(Date:10/20/2014)... Convey Computer , the leader in ... State University won first place in the 2014 ... the team’s solution achieved the highest overall performance in ... place finisher. , Experts from all segments of the ... challenge, using a variety of design tools, hardware and ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
... 18 W. R. Grace & Co. (NYSE: ... Court for the District of Delaware of the previously announced ... as of September 13, 2010 pursuant to which W. R. ... & Co., will purchase Synthetech, Inc. (OTC Bulletin Board: ...
... work done at the Department of Energy,s Oak Ridge ... unexpected magnetism between two dissimilar materials. The results, ... for the design of future electronic devices for computations ... Materials Science and Technology Division. The work was performed ...
... Reportlinker.com announces that a new market ... Global Automated And Rapid ... http://www.reportlinker.com/p092467/Global-Automated-And-Rapid-Microbiological-Tests-Industry.html This report analyzes ... Microbiological Tests in US$ Million by the ...
Cached Biology Technology:Synthetech Announces Bankruptcy Court Approval of Merger With W. R. Grace Subsidiary 2Synthetech Announces Bankruptcy Court Approval of Merger With W. R. Grace Subsidiary 3ORNL theorist part of team that discovers unexpected magnetism 2Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 2Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 3Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 4Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 5Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 6Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 7Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 8Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 9Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 10Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 11Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 12Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 13Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 14Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 15Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 16Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 17Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 18Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 19Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 20Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 21Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 22Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 23Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 24Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 25
...
p27 rabbit polyclonal antibody...
... Rabbit polyclonal to Ki67 - Proliferation Marker, ... cell cycle related nuclear protein, expressed by ... active cell cycle (G1, S, G2 and ... (G0) cells. Ki67 antibodies are useful in ...
UBC13 Antibody...
Biology Products: