Navigation Links
What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock

. It's like a conductor who listens to the orchestra, which is composed of individual musicians. Then, with the beat of his baton, the conductor synchronizes the orchestra so that listeners hear a coordinated sound."

Thus, in essence, the entire brain is an intricate interval timing machine, in which individual structures busy with their own neural tasks, generate resonances that integrate to become ticks of the neural clock.

Meck, Buhusi and their clockwork colleagues are using an array of experimental techniques to try to identify this "baton" timing signal and to refine the theory. These include studies using genetically modified mice, pharmacological tools, recording of electrical brain signals in ensembles of brain cells and functional magnetic resonance imaging of the brain.

For example, they are studying how the clock's ticking changes in Parkinson's patients as they change levels of their medication, which effects the amount of dopamine in their brains. Dopamine has been implicated as a key signaling molecule in the neuronal circuitry of the timing machinery.

"When Parkinson's patients are on their medication, they time quite normally," said Meck. "But as their medication wears off, we can see their clock slow down by recording their brain signals."

Said Meck of their research, "We're addressing two challenges. One is to find the molecular processes that underlie this internal clock. And the second challenge is to build more realistic models of how this timing process works, with constant, parallel input from throughout the brain." In such studies, the researchers face the daunting process of trying to monitor the intricate swirling of neural activity throughout the entire brain, said Meck.

"Looking at only one place in the brain for the interval clock is like the blind man feeling just the toe of the elephant and trying to describe how it works," he said. "While we're very excited about our success so far, we
'"/>

Source:DukeNews


Page: 1 2 3 4

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the addition ... Systems Market" report to their offering. ... security market is estimated to grow at a CAGR of ... a larger share in this market, Canada ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to current ... enables HITLAB to conduct regulated smart device and smart ... safety and research quality. "HITLAB is determined ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... to their offering. One major trend ... continuous advances in technology, it is important to upgrade ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... scientists demonstrated a new method for developing wrinkled hard ... focused ion beam. By controlling the direction and intensity ... on flat areas of polydimethylsiloxane, a silicon-based organic polymer ... Putty). The technique has potential use for biological sensors ...
... quite strong memories of past events like an exciting holiday ... how the brain keeps track of the temporal sequence in ... or after Mary left the party? , Previous findings ... University of Lübeck have confirmed the widely held view that ...
... The freeze-frame image of a molecular relay race, in which ... another enzyme, has solved a key mystery to how cells ... Children's Research Hospital. A report on this work appears in ... , The St. Jude discovery explains how a simple chemical ...
Cached Biology News:Applied scientists create wrinkled 'skin' on polymers 2Chemical switch triggers critical cell activities 2Chemical switch triggers critical cell activities 3
(Date:1/22/2015)... 22, 2015 Diagenode, Inc., a ... the Bioruptor® and complete solutions for epigenetics research, ... immunoprecipitation, alleviating the need for manual processing. The ... for ChIP of histones or transcription factors and ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
(Date:12/25/2014)... December 25, 2014 The report “Service ... Product Type & Provider Type - Global Advancements, Worldwide ... with an in-depth analysis and forecasting of revenues. ... through 221 pages and in-depth TOC on “Service Quality ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... BlueFire Ethanol Fuels, Inc. (OTC Bulletin Board: BFRE), a ... through the production of ethanol from non-food cellulosic wastes, ... biorefinery to Fulton, Mississippi. , (Logo: ... awarded a $40 million dollar grant from the U.S. ...
... ... indicated that receiving earlier seasonal flu shot can double the risk of ... the World Health Organization and delays in the flu shot program in ... about the safety and efficacy of all flu shots along with the ...
... LES ULIS, France, October 14 , ... Excimer System for,Psoriasis and Vitiligo in the United States , ... manufacturer of solid state lasers,announced today that it has entered ... developer of light-based,systems for medical and cosmetic treatments, for Quantel,s ...
Cached Biology Technology:Department of Energy Grants BlueFire Approval for Site Change 2Department of Energy Grants BlueFire Approval for Site Change 3Department of Energy Grants BlueFire Approval for Site Change 4FluStop natural flu remedy sales increase 700% with confusion about new flu shot study and H1N1 2Quantel Signs a Distribution Agreement With US-based National Biological 2
...
Mouse monoclonal antibody raised against a partial recombinant L3MBTL2. NCBI Entrez Gene ID = L3MBTL2...
Mouse monoclonal antibody raised against a partial recombinant QARS. NCBI Entrez Gene ID = QARS...
96-well format (For processing samples on microplate-size MALDI target plates such as those from Bruker, Shimadzu, Thermo, and PerkinElmer) Packaging: 2 / pack...
Biology Products: