Navigation Links
What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock

. It's like a conductor who listens to the orchestra, which is composed of individual musicians. Then, with the beat of his baton, the conductor synchronizes the orchestra so that listeners hear a coordinated sound."

Thus, in essence, the entire brain is an intricate interval timing machine, in which individual structures busy with their own neural tasks, generate resonances that integrate to become ticks of the neural clock.

Meck, Buhusi and their clockwork colleagues are using an array of experimental techniques to try to identify this "baton" timing signal and to refine the theory. These include studies using genetically modified mice, pharmacological tools, recording of electrical brain signals in ensembles of brain cells and functional magnetic resonance imaging of the brain.

For example, they are studying how the clock's ticking changes in Parkinson's patients as they change levels of their medication, which effects the amount of dopamine in their brains. Dopamine has been implicated as a key signaling molecule in the neuronal circuitry of the timing machinery.

"When Parkinson's patients are on their medication, they time quite normally," said Meck. "But as their medication wears off, we can see their clock slow down by recording their brain signals."

Said Meck of their research, "We're addressing two challenges. One is to find the molecular processes that underlie this internal clock. And the second challenge is to build more realistic models of how this timing process works, with constant, parallel input from throughout the brain." In such studies, the researchers face the daunting process of trying to monitor the intricate swirling of neural activity throughout the entire brain, said Meck.

"Looking at only one place in the brain for the interval clock is like the blind man feeling just the toe of the elephant and trying to describe how it works," he said. "While we're very excited about our success so far, we
'"/>

Source:DukeNews


Page: 1 2 3 4

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws against ... are piloting the North American and European automotive sector ... growing, gesture recognition systems that are intuitive and able ... in the industry. New analysis from ... Recognition Market in Europe and ...
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... under Ralf Sommer,s microscope: his research object, the roundworm ... in its side and devours the oozing contents. The squirming ... Caenorhabditis elegans may be a close relative of ... strong "teeth". Pristionchus , impressive hunting technique though is ...
... to know how plants grow, reproduce and communicate? Hundreds ... Berkeley and Cornell to McGill and the University of ... all things green: Plant Biology 2010. Media are welcome ... 2010 - Joint Annual Meetings of American Society of ...
... has received a prestigious $56.8 million Clinical and Translational ... to support and promote scientific discoveries and their application ... CTSA will have an important focus on health issues ... The award, which will be distributed over the ...
Cached Biology News:A worm bites off enough to chew 2Flowers do it, trees do it: Symposium on plant reproduction 2USC wins $56.8M NIH award for clinical and translational research 2USC wins $56.8M NIH award for clinical and translational research 3
(Date:12/24/2014)... New York (PRWEB) December 23, 2014 According ... the Long Island Affiliate of ITRA Global, the national office ... but steady recovery. This is evidenced by the third ... strong stock market. Low energy costs have held inflation ... The only negative is the housing market remaining soft. , ...
(Date:12/24/2014)... 23, 2014 Nashville Fertility Center announced ... treasurer for the American Society for Reproductive Medicine (ASRM), ... research in reproductive medicine. In his new role ... the executive board and will have a voice in ... has actively supported ASRM since 1984 when he joined ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Pipette.com announces ... their Twitter followers can submit their #HolidayInTheLab pictures for ... their lab mates. , For those struggling to think ... the Pipette.com Holiday in the Lab Contest provides the ... Twitter followers to send pictures of their chemistree, ...
(Date:12/24/2014)... Vermillion, Inc. (Nasdaq:   VRML), a ... today that investors including Oracle Investment Management, ... several Vermillion directors have agreed to purchase approximately ... stock and warrants to purchase unregistered shares of ... Under the terms of the private ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... Aug. 5, 2011 Ardea Biosciences, Inc. (Nasdaq: ... development of small-molecule therapeutics for the treatment of serious ... the second quarter and six months ended June 30, 2011. ... initial results from the ongoing extension portion of our ...
... way to design computer chips and electronic circuitry for ... of electrical engineers at Vanderbilt University has developed all ... of thin films of nanodiamond. They have created diamond ... are a key element in computers., "Diamond-based devices have ...
... 2011 Dyadic International, Inc. ("Dyadic") (OTC Pink: ... discovery, development, manufacture and sale of enzyme and ... biopharmaceutical industries, today announced financial results for the ... contained in this press release should be read ...
Cached Biology Technology:Ardea Biosciences Reports Recent Accomplishments and Second Quarter 2011 Financial Results 2Ardea Biosciences Reports Recent Accomplishments and Second Quarter 2011 Financial Results 3Ardea Biosciences Reports Recent Accomplishments and Second Quarter 2011 Financial Results 4Ardea Biosciences Reports Recent Accomplishments and Second Quarter 2011 Financial Results 5Ardea Biosciences Reports Recent Accomplishments and Second Quarter 2011 Financial Results 6Ardea Biosciences Reports Recent Accomplishments and Second Quarter 2011 Financial Results 7Designing diamond circuits for extreme environments 2Designing diamond circuits for extreme environments 3Dyadic International Reports 2011 Second Quarter Financial Results 2Dyadic International Reports 2011 Second Quarter Financial Results 3Dyadic International Reports 2011 Second Quarter Financial Results 4Dyadic International Reports 2011 Second Quarter Financial Results 5Dyadic International Reports 2011 Second Quarter Financial Results 6Dyadic International Reports 2011 Second Quarter Financial Results 7
... potential applications for the use of small ... expression via the RNA interference (RNAi) pathway ... and molecular biology fields. siRNA for experimental ... chemically or enzymatically, and then transfected into ...
... (GST) is commonly used as a fusion ... (1). The GSTTag sequence has been reported ... cases the solubility of its fusion partners. ... form, GSTTag fusion proteins can be purified ...
a1-Antitrypsin (human, alpha-1 AT)...
... 7500ce meets the demands of the routine ... performance from reliable, robust and simple to ... power in the most challenging sample matrices ... equally suited to the toughest analytical challenges ...
Biology Products: