Navigation Links
Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check

mes. Although this may seem paradoxical ?intuitively, more careless enzymes should mean more mutations ?each of these enzymes is tailored to deal with certain specifics types of DNA damage. This specialization is what keeps the level of mutation, and thus the cancer risk, low. But the existence of this variety of specialist enzymes implies precise regulation of the system ?otherwise copying by the careless enzymes might get out of control and lead to an unhealthy proliferation of mutations.

Prof. Livneh and his team recently discovered a security mechanism that prevents such proliferation of mutations. This mechanism allows the right enzyme to go to work at the right time, and only when it's needed. The main components in this system are the proteins p53 and p21. p53, named "molecule of the year" several years ago by Science, is well known for its central role in reining in cancer processes in the cell. In this case, the proteins seem to act as supervisors, taming the careless enzymes and keeping them in careful check. The scientists' research showed that if the functioning of p53 or its relative, p21, is harmed, the activities of the careless enzymes can go into overdrive, leading to more mutations.

The actual mechanism works with a sort of molecular clamp that holds the DNA copying enzyme onto the strand of DNA. When the enzyme encounters DNA damage, a small molecule called ubiquitin attaches to the clamp. The ubiquitin, in this case, serves to anchor replacement DNA polymerase molecules ?careless ones ?to the clamp. p53 enters the picture when it is alerted to the damage and causes p21 to be created. The p21 then acts as a sort of facilitator, helping to fasten the proper ubiquitin in place and clearing stalled DNA polymerase out of the way so its replacement can get to work. Thus, these two proteins manage to help the body's cells maintain a crucial balance, allowing them to divide and multiply while keeping the mutation rate, and therefore th
'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1 2 3

Related biology news :

1. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
2. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
3. Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance
4. BioMed Central welcomes the new National Institutes of Health public access policy
5. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
6. Virginia Tech, Nanjing Institute researchers discover half-billion year-old fossils
7. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
8. Virginia Bioinformatics Institutes launches microbial database
9. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
10. UCLA AIDS Institute researchers find a peptide that encourages HIV infection
11. Wisconsin scientists grow critical nerve cells
Post Your Comments:
(Date:8/20/2014)... of sunscreen and seawater signals a relaxing trip to ... idyllic beach vacation comes with an environmental hitch. When ... sea, they can become toxic to some of the ... many other marine animals. Their study appears in the ... Antonio Tovar-Sanchez and David Snchez-Quiles point out that other ...
(Date:8/20/2014)... bags could one day be made out of cocoa, ... now reporting. The novel process they developed and their ... agricultural and plastic waste problems, appear in the ACS ... Bayer and colleagues at the Italian Institute of Technology ... 2012, its production reached 288 million tons worldwide, but ...
(Date:8/20/2014)... to about 4,000 members, it triggers an important first ... special type of comb used for rearing male reproductive, ... of Neurobiology and Behaviour at Cornell University, led by ... honeybee colonies. The results are published in Springer,s journal ... , Reproduction isn,t always a honeybee colony,s top priority. ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2
... time, researchers at the UCLA Henry Samueli School of ... its limits by genetically modifying Escherichia coli , ... unusually long-chain alcohols essential in the creation of biofuels. ... synthesize long-chain alcohols containing five carbon atoms," said James ...
... your time among stores, restaurants and skyscrapers, it may be ... A new study in Psychological Science , a journal ... in nature may be more beneficial for mental processes than ... Jonides, and Stephen Kaplan from the University of Michigan designed ...
... and make way for a "green" holiday. Here are ... environmentally friendly, courtesy of the American Chemical Society (ACS), ... Chemistry Institute. The Institute works to foster the discovery ... generation and use of hazardous substances. ,To reduce your ...
Cached Biology News:Researchers push nature beyond its limits to create higher-density biofuels 2
(Date:8/20/2014)... 20, 2014 /PRNewswire-iReach/ -- A case study from ... the school,s bioengineering department and the Intel® Internet ... Software Academic Program, UCSD,s research focuses on exploring ... body.  Photo - http://photos.prnewswire.com/prnh/20140819/137540 ... work of Dr. Todd P. Coleman , ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
(Date:8/19/2014)... CA (PRWEB) August 19, 2014 Robin ... Parkinson’s disease can take on an individual. Symptoms ... decreased facial expression, problems swallowing and severe depression. ... the dying off of dopamine producing neurons of the ... from a disease that slowly and progressively gets worse, ...
(Date:8/19/2014)... 19, 2014   Synthetic Biologics, Inc. ... anti-infective biologic and drug programs targeting specific pathogens ... that its novel C. difficile development ... Interscience Conference on Antimicrobial Agents and Chemotherapy ... Synthetic Biologics, Senior Vice ...
Breaking Biology Technology:Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4
... colon, and ... prostate cancers-, TORONTO, Oct. ... and developing the next wave of,antibody therapeutics, today announced that the ... completed its first,toxicology study and has shown good efficacy in animal ...
... Wrong Should be put ... Stefano, ROME, October 23 Giovanni Di Stefano has called ... In,a letter supported by Dr John Trestrail who researched the flawed,conviction ... for,the pardon to be ,effective forthwith notwithstanding the passage of time.,Other ...
... ON, Oct. 22 /PRNewswire-FirstCall/ - YM BioSciences Inc.,(AMEX: ... oncology company that identifies,develops and commercializes differentiated products ... Directors has adopted a renewed,Shareholder Rights Plan Agreement. ... treatment of shareholders in connection with any take-over ...
Cached Biology Technology:ARIUS announces cancer stem cell antibody program successfully completes first toxicology study 2ARIUS announces cancer stem cell antibody program successfully completes first toxicology study 3YM Biosciences announces adoption of renewed Shareholders' Rights Plan 2YM Biosciences announces adoption of renewed Shareholders' Rights Plan 3
Mouse polyclonal antibody to PRDM2 - PR domain containing 2, with ZNF domain...
Anti Human S14G-Humanin Polyclonal Antibody...
... familiar interface for data capture, recording, ... transition from paper to this powerful ... contains an integrated LIMS, notary service, ... These functions allow LABTrack to achieve ...
High voltage electrophoresis power supply...
Biology Products: