Navigation Links
Weizmann Institute scientists develop a general 'control switch' for protein activity

Our bodies could not maintain their existence without thousands of proteins performing myriad vital tasks within cells. Since malfunctioning proteins can cause disease, the study of protein structure and function can lead to the development of drugs and treatments for numerous disorders. For example, the discovery of insulin’s role in diabetes paved the way for the development of a treatment based on insulin injections. Yet, despite enormous research efforts led by scientists worldwide, the cellular function of numerous proteins is still unknown. To reveal this function, scientists perform various genetic manipulations to increase or, conversely, decrease the production of a certain protein, but existing manipulations of this sort are complicated and do not fully meet the researchers’ needs.

Prof. Mordechai “Moti” Liscovitch and graduate student Oran Erster of the Weizmann Institute’s Biological Regulation Department, together with Dr. Miri Eisenstein of Chemical Research Support, have recently developed a unique “switch” that can control the activity of any protein, raising it several-fold or stopping it almost completely. The method provides researchers with a simple and effective tool for exploring the function of unknown proteins, and in the future the new technique may find many additional uses.

The switch has a genetic component and a chemical component: Using genetic engineering, the scientists insert a short segment of amino acids into the amino acid sequence making up the protein. This segment is capable of binding strongly and selectively to a particular chemical drug, which affects the activity level of the engineered protein by increasing or reducing it. When the drug is no longer applied, or when it is removed from the system, the protein returns to its natural activity level.

As reported recently in the journal Nature Methods, the first stage of the method consists of preparing a set of genetically engineered proteins (ca
'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1 2 3

Related biology news :

1. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
2. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
3. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
4. Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance
5. BioMed Central welcomes the new National Institutes of Health public access policy
6. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
7. Virginia Tech, Nanjing Institute researchers discover half-billion year-old fossils
8. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
9. Virginia Bioinformatics Institutes launches microbial database
10. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
11. UCLA AIDS Institute researchers find a peptide that encourages HIV infection
Post Your Comments:
(Date:6/17/2015)... Germany , June 17, 2015 ... QIA) today launched new Investigator ® STR assay kits ... the United States . The new genetic fingerprint ... genomic markers (short tandem repeats or STRs) for DNA matching. ... the quality of DNA in each sample, a novel QIAGEN ...
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - ... partnership centralized around the incorporation of handyem,s HPC-150 ... diagnostic laboratory, the Mo-POD™. This unprecedented model of ... International Conference at the Pennsylvania ... from June 15 th to 18 th ...
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... 2015 from previously communicated that it will amount to at ... 390 MSEK. Due to the rapid increase in market growth ... from the previously communicated guidance that revenue for 2015 will ... 2015 will amount to approximately 2,200 MSEK. Due ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... Nitrous oxide is a potent greenhouse gas and a ... the ozone. Intensively managed, grazed pastures are responsible for ... excrement. Biochar is potentially a mitigation option for reducing ... carbon can be sequestered in the soil. Biochar also ...
... 17, 2011 (BRONX, NY) Researchers at Albert ... that members of an enzyme family found in humans and ... in regulating cell motility. Their findings suggest an entirely new ... cancer. , David Sharp, Ph.D. , associate professor of ...
... now lives in cities, yet we know little about how ... kind, ecologists in Indianapolis, USA have used 70 year-old dried ... plants. The results are published this week in the British ... Dr Rebecca Dolan, director of the Friesner Herbarium, Butler University, ...
Cached Biology News:Can biochar help suppress greenhouse gases? 2Enzyme can steer cells or possibly stop them in their tracks 2Ecologists use 70-year-old pressed plants to chart city's vanishing native flora 2
(Date:6/30/2015)... Kjell Lindgren , who is making final preparations for ... International Space Station , will be available for live ... 7. Lindgren will participate from the Gagarin Cosmonaut ... The interviews will be preceded at 7:30 a.m. by a ... To schedule an interview, media must contact Stephanie Stoll ...
(Date:6/30/2015)... Americord Registry, one of the fastest growing cord blood banks ... at Kirkland & Ellis LLP, as the newest member of ...   "We are thrilled about Andrew Horne,s ... , CEO of Americord. "He brings a wealth of knowledge ... growth and vision." Andrew Horne is ...
(Date:6/30/2015)... ... 2015 , ... With its latest polyacrylonitrile (PAN) membrane, Sterlitech ... flow rates in comparison to nylon or polyethersulfone (PES). Its unique nanofiber ... liquid flow while trapping particulates as small as 0.2 micron in width. , ...
(Date:6/30/2015)... ... June 30, 2015 , ... The maximum number of shares ... outstanding common shares (including shares of unvested restricted stock). On June 29, 2015, the ... price of Cryo-Cell’s shares reported on the OTCBB was $2.29 per share. , The ...
Breaking Biology Technology:NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2Americord Registry Announces Andrew Horne as Advisory Board Member 2New Nanofiber Membrane Provides Fast, Efficient Filtration 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 3
... (USP) Convention,an official public standards-setting authority for all ... on December 4, 2008,transferred all rights, ownership and ... This announcement comes one year after Quantros,and ... all,operations, support, marketing and sales for the MEDMARX ...
... magazine profiles the best up-and-coming young investigators, selected by the ... NEW YORK, Dec. 8 Genome Technology magazine has named ... "Tomorrow,s PIs" special edition. , , ... biological research through the eyes of some of the best ...
... COUNTY, Calif., Dec. 8 Beckman Coulter,Inc. (NYSE: ... simplify, automate, and innovate complex biomedical tests, will host its,Annual ... December 16,2008, from 9:00 a.m. to 12:00 p.m. (ET). , ... ) , The live ...
Cached Biology Technology:Quantros Acquires MEDMARX(R) from United States Pharmacopeia (USP) 2Quantros Acquires MEDMARX(R) from United States Pharmacopeia (USP) 3Quantros Acquires MEDMARX(R) from United States Pharmacopeia (USP) 4Genome Technology Names 2008 'Tomorrow's PIs' 2Genome Technology Names 2008 'Tomorrow's PIs' 3Genome Technology Names 2008 'Tomorrow's PIs' 4
... White crystalline solid. PACKAGED UNDER ... Contaminants: DNases, proteases, RNases: none ... nm): ≤0.500; (100 mM, 1 cm, 280 ... Soluble in H 2 O. RTECS ...
... Genome ChIP-on-chip Microarray is specifically designed ... cerevisiae) DNA binding proteins by pairing ... microarrays. This set delivers robust hybridization ... true binding events and fewer false ...
... Salmonella genomes has allowed the development of ... pairs. The S. enterica Typhimurium (strain LT2) ... bp; 4,440 ORFs) and a plasmid, pSLT ... Sigma-Genosys have been designed to amplify all ...
... productivity and allows you to achieve a higher ... beyond traditional paper-based weighing processes into a powerful ... Control of ... PR, SR, PG-S, PG, SG, AT, MT, UMT, ...
Biology Products: