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Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

, a kind of cell used in many cell-culture experiments. But Dr. Ryan said the findings have broad implications for cells throughout the body, including those closely tied to brain disorders, cardiac illness, and other major conditions.

He pointed out that clathrin is also important to cellular mechanisms other than endocytosis, including those occurring deep inside the cell.

"Now that we have a better handle on this relationship, we're going to go beyond looking at clathrin per se, and try and investigate other players in the endocytotic process," he said. ÒWe're going to ask questions such as, 'OK, if I tweak this molecule, how does that change clathrin's role in all of this?'Ó

"It's really quite exciting," Dr. Ryan said. "This new methodology, coupled with our better understanding of clathrin, should really help crack this field wide open."

The study was funded by grants from the National Institutes of Health and the Irma T. Hirschl Trust.

Co-researchers included Dr. Charles T. Yokoyama and Howard S. Moskowitz, both of the Department of Biochemistry at Weill Cornell Medical College.


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Source:Cornell University


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