Navigation Links
Weight control protein may yield antiobesity drugs

A weight control protein with a key role in the brain's ability to monitor body fat content may yield new approaches for treating obesity and type 2 diabetes, according to a new report in the August issue of Cell Metabolism. The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers said.

SH2-B, which has multiple functions in cells throughout the body, keeps the brain sensitive to the fat hormone leptin, found researchers from the University of Michigan Medical School. Produced by fat tissue, the leptin hormone sends signals to the brain about the body's fat content. That signal, in turn, elicits adjustments in appetite and energy expenditure to maintain normal body weight.

Mice lacking SH2-B overeat and become obese, the team found. The animals additionally develop a metabolic syndrome characterized by high blood concentrations of leptin, insulin, and lipids. They also develop fatty livers and high blood sugar, the group reports.

"Our findings reveal SH2-B as an important positive regulator of leptin sensitivity inside cells of the brain region known as the hypothalamus," said senior author of the study, Liangyou Rui. The hypothalamus is a key area in the central nervous system that integrates neuronal, hormonal, and nutrient-related signals to maintain body weight, he explained.

Leptin is a hormone produced by fat that normally decreases food intake and increases energy expenditure. In many species, including humans, the hormone acts to stabilize weight and glucose balance through activating its receptors in the hypothalamus.

Earlier work by Rui's group found that SH2-B binds to a second protein, JAK2, to promote leptin signaling in cultured cells. Further work then identified a physiological role for SH2-B in the regulation of blood glucose; mice deficient for the protein develop insulin resistance and type 2 diabetes, they found.

The current
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
2. Weighting cancer drugs to make them hit tumors harder
3. Weighty viruses
4. Ancient olfaction protein is shared by many bugs, offering new pest control target
5. Gene variations explain drug dose required to control seizures
6. U-M scientists find genes that control growth of common skin cancer
7. Scientists discuss improved biopesticides for locust control in West Africa
8. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
9. To control germs, scientists deploy tiny agents provocateurs
10. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
11. Master gene controls healing of skin in fruit flies and mammals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Weight control protein may yield antiobesity drugs

(Date:8/1/2014)... Davis Center for Neuroscience and Department of Psychology ... Faculty Fellowship from the U.S. Department of Defense. ... work on learning and memory in Ranganath,s Dynamic ... project aims to connect neural oscillations, which are ... and hippocampus, brain regions that are known to ...
(Date:8/1/2014)... a key component of phloem, the conductive tissue through ... signalling molecules. Elongated cylindrical cells are capped at one ... form sieve tubes which in turn form a network ... are very special cells which play an important role ... been known about their differentiation," says Professor Yk Helariutta ...
(Date:8/1/2014)... -- LiveScan Service Provider Binary Biometrics is pleased to welcome Kevin ... will improve its mobile service capabilities and add more daily appointments, which will ... service several new cities such as, but not limited to, Daytona ... Deltona , Edgewater , Holly ... Beach , Oak Hill , Orange City ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3
... available in French . Researchers at ... of Canada, the University of Toronto and the SETI ... highly unique spring located on Axel Heiberg Island in ... explains that the Lost Hammer spring supports microbial life, ...
... 3, 2010 A cancer conference dedicated to increased ... bridge Western and Native American approaches to disease and ... Navajos are learning about cancer, adopting measures to help ... opening up to new therapies. The 3rd annual ...
... This release is available in French . , ... Social Sciences, two teams of researchers led by Professor Barbara ... Goldsmiths, University of London, U.K., have brought research in intelligent ... have developed a highly sophisticated concept of interactive clothing whereby ...
Cached Biology News:Could life survive on Mars? Yes, expert says 23rd annual Ft. Defiance Cancer Awareness Conference set for June 5 23rd annual Ft. Defiance Cancer Awareness Conference set for June 5 3Innovative research reawakens human memories through intelligent textiles 2
(Date:8/1/2014)... (PRWEB) August 01, 2014 RURO, ... Solutions provider, today officially announces the opening of ... Boji Science Park, Baoshan District in Shanghai, PRC, ... is under the management of Mr. Shen Gang, ... In the past three years, RURO’s has installed ...
(Date:8/1/2014)... 1, 2014 The  PROPEL Center  of the  ... success rate of early-stage life sciences companies in ... awarded 15 grants to help Illinois ... Conference   in Chicago .   ... North America , bringing more than ...
(Date:8/1/2014)... 2014 BCC Research ( http://www.bccresearch.com ) ... TECHNOLOGIES AND GLOBAL MARKETS , that the global market ... grow to nearly $38.8 billion by 2018, with a ... aptamer delivery category, the fastest moving segment of the ... The field of RNAi therapeutics has shown tremendous growth ...
(Date:7/31/2014)... 2014 Food and natural product ... for food alternatives that offer variety, as well ... ingredient market has numerous players operating in the ... Force Technology (VFT). VFT is a science-driven ... patterns, all tested to produce stable, effective and ...
Breaking Biology Technology:RURO Opens Office in Shanghai, China 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 2iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 3iBIO Institute's PROPEL Center Awards Grants for AdvaMed 2014 to Early-Stage Life Sciences Companies 4Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 3Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2
... April 22 /Xinhua-PRNewswire/ -- Fufeng Group Limited,("Fufeng" or ... "the Group"; HKEx: 546), a leading vertically integrated,manufacturer ... results for the year ended 31 December 2007., ... sales volume of major,products, the Group,s turnover increased ...
... NATICK, Mass., April 21 Boston Scientific,Corporation (NYSE: BSX ... 31, 2008, as well as guidance for net sales and,earnings ... First quarter highlights:, -- Achieved net sales of ... earnings through ongoing, stringent expense management -- Maintained leading ...
... in Response to ... Consumer Demand for Water Safety, MONROVIA, Calif., ... this week, addressing consumer concerns,regarding private well water. Available now ... contaminants with easy-to-use,at-home results, most of which can be completed ...
Cached Biology Technology:Fufeng Announces 2007 Annual Results 2Fufeng Announces 2007 Annual Results 3Boston Scientific Announces Results for First Quarter Ended March 31, 2008 2Boston Scientific Announces Results for First Quarter Ended March 31, 2008 3Boston Scientific Announces Results for First Quarter Ended March 31, 2008 4Boston Scientific Announces Results for First Quarter Ended March 31, 2008 5Boston Scientific Announces Results for First Quarter Ended March 31, 2008 6Boston Scientific Announces Results for First Quarter Ended March 31, 2008 7Boston Scientific Announces Results for First Quarter Ended March 31, 2008 8Boston Scientific Announces Results for First Quarter Ended March 31, 2008 9Boston Scientific Announces Results for First Quarter Ended March 31, 2008 10Boston Scientific Announces Results for First Quarter Ended March 31, 2008 11Boston Scientific Announces Results for First Quarter Ended March 31, 2008 12Boston Scientific Announces Results for First Quarter Ended March 31, 2008 13Boston Scientific Announces Results for First Quarter Ended March 31, 2008 14Boston Scientific Announces Results for First Quarter Ended March 31, 2008 15Boston Scientific Announces Results for First Quarter Ended March 31, 2008 16Boston Scientific Announces Results for First Quarter Ended March 31, 2008 17Boston Scientific Announces Results for First Quarter Ended March 31, 2008 18Silver Lake Research Unveils Watersafe(R) Well Water Test Kit 2
AC input: 50-60 Hz230 V...
... The PATH™ Protein Microarray Slide features ... immunoassays. The,PATH™ Slide is the first ... many benefits of nitrocellulose in a ... excellent signal-to-noise ratios. ,The PATH™ ...
AC input: 50-60 Hz 115-120 V...
... hybridization of DNA or Protein microarrays printed ... glass slides. The proprietary design of the ... flatness, as is often the case with ... (67uL analytical cavity volume) eliminates the need ...
Biology Products: