Navigation Links
Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs

A "starry sky" map linking the myriad interactions between the influenza virus and its human host will help guide researchers in creating new anti-viral drugs, say researchers at UT Southwestern Medical Center.

The on-line map, part of a project called Reactome, is intended to teach scientists about parts of the influenza lifecycle they might not be familiar with, and to help researchers look at specific reactions and figure out ways to block them.

"Understanding how influenza reacts with its host is really critical for the rational design of anti-viral drugs and new vaccines," said Dr. Richard Scheuermann, professor of pathology at UT Southwestern.

Reactome, online at, was created in 2004 and includes a variety of biochemical pathways for processes such as cell death in several species, primarily human.

Individual reactions are shown as separate items, which are linked by arrows to associated reactions. The diagrams resemble constellations; hence the "starry sky" nickname.

The influenza pathway component and a simultaneous HIV database going online mark the first time Reactome has displayed interactions between an infectious pathogen and its host, Dr. Scheuermann said.

Pathogens such as influenza have evolved to use hosts to promote their growth, while at the same time blocking the host reactions that recognize and respond to infection. Each year, for example, winter is marked by the outbreak of flu caused by new viruses that the human immune system doesn't recognize.

The new Reactome influenza database outlines a typical virus life cycle, which will be updated as more research becomes available.

"In the future, the goal is to build out all of the host-pathogen reactions," Dr. Scheuermann said.

UT Southwestern's participation was part of the BioHealthBase Bioinformatics Resource Center project, a collaboration between Dr. Scheuermann's lab and a bioinformatics software engine ering team at Northrop Grumman Information Technology funded by the National Institute of Allergy and Infectious Diseases.

Reactome is an NIH-funded collaboration between Dr. Lincoln Stein's laboratory at Cold Spring Harbor Laboratory in New York and the laboratory of Dr. Ewan Birney of the European Bioinformatics Institute, part of the European Molecular Biology Laboratory, in Hinxton, UK.


Source:UT Southwestern Medical Center

Related biology news :

1. Scientists identify new model Of NK cell development
2. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
3. Molecular models advance the fight against malaria
4. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
5. Genetic therapy reverses nervous system damage in animal model of inherited human disease
6. Disease progression model of pancreatic cancer developed by Penn researchers
7. A new way to share models of biological systems
8. Understanding biases in epidemic models important when making public health predictions
9. Climate model links higher temperatures to prehistoric extinction
10. Gene therapy advance treats hemophilia in mouse models
11. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
Post Your Comments:

(Date:11/17/2015)... Paris from 17 th until 19 th ... from 17 th until 19 th November 2015.   ... the first combined scanner in the world which scans both ... two different scanners were required: one for passports and one ... same surface. This innovation is an ideal solution for electronic ...
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. ... human interface solutions, today announced expansion of its ... ™ touch controller and display driver integration ... of smartphones. These new TDDI products add to ... (HD resolution), TD4302 (WQHD resolution), and TD4322 (FHD ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... INCLINE VILLAGE, Nev. , Nov. 24, 2015  PDL ... John P. McLaughlin , the company,s president and chief ... Piper Jaffray Healthcare Conference next week in New ... and will occur on Tuesday, December 1, 2015 at 9:30 ... and Presentations." Please connect to the website at least 15 ...
(Date:11/24/2015)... , Nov. 24, 2015 According to two ... in 2005. This is something that many doctors, scientists, and ... One questions remains: with fewer PSA tests being done, will ... Dr. David Samadi, "Despite the efforts ... disease remains the second leading cancer cause of death in ...
(Date:11/23/2015)... HONG KONG, Nov. 23, 2015 China Cord ... "Company"), China,s leading provider of cord blood collection, laboratory ... services, today announced its preliminary unaudited financial results for ... 2016 ended September 30, 2015. --> ... Highlights , Revenues for the second quarter of ...
(Date:11/23/2015)... The royalty-free a greement a llows ... 112 low- and m iddle-i ncome ... --> The Medicines Patent Pool (MPP) today announced its ... with Bristol-Myers Squibb for daclatasvir, a novel direct-acting antiviral that ... virus.  The royalty-free licence will enable generic manufacture of daclatasvir ...
Breaking Biology Technology: