Navigation Links
Waking a sleeping virus

w materials to make new viruses.

"A good strategy in fighting viruses is to block the activation of viral genes," says Patrice Morand, a physician at the University hospital and the IVMS. "The drugs we currently use against EBV work that way. The problem is that they only interrupt the late phase of the viral cycle. Since ZEBRA is essential to the first steps, waking the virus, blocking it would be much better."

To identify weak points of ZEBRA as potential drug targets Morand and Carlo Petosa from Müller's group created a high-resolution map of the protein's structure. Using the unique technology "platforms" that EMBL and the IVMS have set up in partnership with the neighbouring institutes, they obtained crystals of ZEBRA.

Examining these crystals with high-intensity X-rays at the European Synchrotron Radiation Facility (ESRF) in Grenoble, the scientists found that ZEBRA binds to DNA in a complex of two molecules. A detailed map of the interface between the two ZEBRA molecules revealed that one copy of ZEBRA plugs a large side chain into a deep pocket in the other. "This is an ideal type of structure to try to target with a drug," Petosa says. "If we can find a molecule to block access to the cavity, the copies wouldn't be able to bind to each other and dock onto DNA."

Morand and his colleagues carried out a close study of the pocket, which gave them good idea of what a "plug" would have to look like. The next step will be to screen likely molecules in hopes of finding an inhibitor. "We have been trying to develop an effective way to treat EBV infections for over 20 years, without major successes," Morand says. "Thanks to this partnership between medical research and structural biology that has grown on the Grenoble Polygone Scientifique campus, we are closer than ever before."


'"/>

Source:European Molecular Biology Laboratory


Page: 1 2

Related biology news :

1. Newly discovered protein an important tool for sleeping sickness research
2. Compound might defeat African sleeping sickness, clinical trial beginning this month
3. A large step forward in the fight against African sleeping sickness
4. Resistance and genetic sensitivity to sleeping sickness
5. New study suggests promising drug combinations for sleeping sickness
6. Live vaccines more effective against horse herpes virus
7. MUHC scientists describe genetic resistance to rampant virus
8. Studies clarify risk factors for mother-to-child transmission of hepatitis C virus
9. New possibilities for flu antiviral and vaccine research emerge from Spanish flu virus
10. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
11. Enzyme inhibitors block replication of SARS virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Waking sleeping virus

(Date:7/24/2014)... average over a 35 year period in which the ... of humans on declining animal numbers. This decline matters ... spiders, crustaceans, slugs and worms bring to our day-to-day ... for nutrient cycling, water filtration and human health. , ... by UCL, Stanford and UCSB, focused on the demise ...
(Date:7/24/2014)... two factors that characterize sustainable university and college ... qualified physics teachers. Specifically, one or more faculty ... in combination with institutional motivation and commitment can ... Engineering and Math (STEM) teacher shortages are especially ... way for institutions seeking to increase the number ...
(Date:7/24/2014)... 3.5 billion years of evolutionary trial and error, is ... may be reaching a tipping point. , In a ... published in Science , an international team of ... is contributing to what appears to be the early ... , Since 1500, more than 320 terrestrial vertebrates have ...
Breaking Biology News(10 mins):Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Creating sustainable STEM teacher preparation programs 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3
... March 24, 2008) New BARACLUDE (entecavir) data ... resistance in nucleoside-nave patients through five years of ... patients analyzed, no additional patient developed resistance in ... treatment, the cumulative probability of developing mutations in ...
... HIV-positive African adults who become infected with Salmonella die ... diarrhea. Now, UC Davis School of Medicine scientists have ... findings also implicate a mechanism by which HIV evades ... have found the defect in the immune response that ...
... most often produced from biomass burning, cooking with solid ... the atmosphere three to four times greater than prevailing ... in the journal Nature Geoscience. Scripps Institution of ... and University of Iowa chemical engineer Greg Carmichael, said ...
Cached Biology News:BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients 2BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients 3UC Davis researchers discover how HIV turns food-poisoning into lethal infection 2UC Davis researchers discover how HIV turns food-poisoning into lethal infection 3Black carbon pollution emerges as major player in global warming 2Black carbon pollution emerges as major player in global warming 3
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 /PRNewswire/ ... company in the emerging field of regenerative medicine, ... webcast of a presentation to investors on Tuesday, ... p.m. PDT.  The presentation will include an overview ... To access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics ...
(Date:7/24/2014)... computers have yet to materialise. Yet, scientists are ... such computers faster. One such approach relies on ... by applying an electric field. A new study ... coupled quantum dots (TQDs) with electrical impulses can ... example, should TQDs be used as quantum information ...
(Date:7/24/2014)... 24, 2014 Research and Markets ... and Proteomics Analytical Instruments Market 2014-2018" report to ... Genomics is the study of the gene ... the structure and functions of proteomes or sets of ... technology. Genomics involves the mapping of genes and DNA ...
(Date:7/24/2014)... July 24, 2014 Three companies from ... in Livestrong’s Big C Competition. Out of 700 competition ... headed to the semi-final round. In this round twenty ... accelerator program, complete with mentoring from thought-leaders and medical ... part of the angelMD commitment to the Livestrong vision ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... SAN DIEGO, July 24 Orexigen Therapeutics, Inc. ... fully exercised their overallotment option to purchase an additional 1,500,000 ... announced public offering that priced on July 23, 2009. ... at a public offering price of $7.50 per share, resulting ...
... , , , ... NES-ZIONA, Israel, July 24 PROLOR Biotech, Inc. (OTC Bulletin Board: PBTH), formerly ... private investors to sell up to $10 million of the company,s newly issued ... As part of the agreements, the company closed on the issuance of one ...
... , ... it used to be. ,Affordable biometric technology means you can,t get someone to buddy punch for you, ... from anywhere on the web, at anytime! , ... NSW (PRWEB) July 24, 2009 -- Technology is putting an end to the cat and mouse game ...
Cached Biology Technology:Orexigen(R) Therapeutics Announces Full Exercise of Overallotment Option by Underwriters 2PROLOR Biotech Announces $10 Million Preferred Stock Line From Members of The Frost Group 2PROLOR Biotech Announces $10 Million Preferred Stock Line From Members of The Frost Group 3PROLOR Biotech Announces $10 Million Preferred Stock Line From Members of The Frost Group 4Time Clocks Technology Catches Up With Crooks 2Time Clocks Technology Catches Up With Crooks 3
... to grow, the need for greater detection ... necessary, especially when discerning very similar or ... Confocal Microscope System gives you a level ... available in conventional confocal systems, with detectors ...
... kit provides complete components including positive ... detection of DNA fragmentation in cultured ... of BrdU in the procedure provides ... methods. Results can be analyzed by ...
... Whatever your Ion Chromatography requirements, ... . The newly developed conductivity detector ... ultra-low drift . In addition to ... be used with other detectors, such as ...
... combines the space and time dimensions of a ... optical microscope to open new horizons in biological ... for excitation, the decay of a fluorescence emission ... decay measured. Subtle changes in the local ...
Biology Products: