Navigation Links
Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

In this week's journal Nature, scientists at the Salk Institute for Biological Studies report that they have solved one of the "holy grail" puzzles of developmental biology: the existence of a mechanism that insures that the exterior of our bodies is symmetrical while inner organs are arranged asymmetrically.

In research with zebra fish, as a model for human biology, Juan-Carlos Belmonte and his Salk Institute colleagues found that retinoic acid (vitamin A) is the signal that buffers the influence of asymmetric cues in early-stage embryonic stem cells and allows these cells to develop symmetrically.

In the absence of retinoic acid, the exterior of our bodies would develop asymmetrically, with the result being that our right side would be shorter than the left one.

"On the outside, the human body looks very symmetrical," says Yasuhiko Kawakami, a senior research associate in Belmonte's Gene Expression Laboratory and the first author of the Nature paper. "But, inside the human body, the pattern of the organs is asymmetrical. For example, we don't have two stomachs, one located on the right and the other on the left. We have one stomach, located on the left half."

A complex cascade of signals helps generate the three-dimensional body pattern of the zebra fish as well as the human body. Patterning of the body occurs along three main axes: the head to toe, which arranges organs and structures (front, eyes, nose, mouth, jaw, neck, shoulders, etc.) sequentially; back-front, which distinguishes our back from our front; and left-right, which distinguishes our left and right parts.

The novel findings reported by Belmonte's team illustrate how the development of the antero-posterior and left-right axes is coordinated by vitamin A. Retinoic acid exerts its influence at the stage when the embryonic stem cells enter the node region of the embryo and begin forming the embryo's three main layers of cells that organize into the brain and nervou
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Vitamin D deficiency widespread during pregnancy
2. Vitamins: Science doesnt always match policy
3. Sweet water taste paradoxically predicts sweet taste inhibitors
4. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
5. Low level of extinction during ice age linked to adaptability
6. Key mechanism in genetic inheritance during cell division identified
7. Too much water may be as dangerous as too little during long-distance athletic events
8. Columbia study shows widely used artery clearing device does not help patients during heart attack
9. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
10. Mice brains shrink during winter, impairing some learning and memory
11. Any exposure to tobacco smoke during pregnancy is risky
Post Your Comments:
(Date:7/30/2014)... York University is paving the way for a ... and military troops exposed to poisonous chemicalsparticularly those ... article in the current issue of the journal ... organophosphates, which are compounds commonly used in pesticides ... by NYU School of Engineering Associate Professor of ...
(Date:7/30/2014)... A deep-sea octopus protected and tended her eggs until ... published July 30, 2014 in the open-access journal ... Aquarium Research Institute and colleagues. , Octopuses typically have ... females protect and take care of their fertilized eggs ... eggs for 1 to 3 months, but little is ...
(Date:7/30/2014)... Everybody knows the shortest distance between two points is ... that sperm have been taking the familiar axiom to ... usually thought to be intense, with each racing for ... in some species, sperm form cooperative groups that allow ... , A new study, conducted by Heidi Fisher, ...
Breaking Biology News(10 mins):Engineering a protein to prevent brain damage from toxic agents 2Deep-sea octopus has longest-known egg-brooding period 2When cooperation counts 2When cooperation counts 3
... Researchers from Michigan State University,s departments of Electrical ... new wearable sensor network to assess a person,s physical ... engineering professor Subir Biswas, participants will wear three small, ... lower leg that during any physical activity will ...
... Research (SFBR) in San Antonio have found a gene ... in the blood as a result of a high-cholesterol ... developed at SFBR that has normal blood levels of ... low-cholesterol diet, but extremely elevated levels of LDL cholesterol ...
... Animal flocks, be it honeybees, fish, ants or birds, ... decisions at a moment,s notice, a phenomenon which has ... today, Wednesday 15 September, in New Journal of ... German Physical Society), uses a particle model to explain ...
Cached Biology News:Wearable sensor technology to measure physical activity 2Scientists find gene for high cholesterol in blood 2Understanding behavioral patterns: Why bird flocks move in unison 2
(Date:7/30/2014)... Yuma Regional Cancer Center Officially Opens ... comprehensive cancer care to Yuma, Arizona. , The ... has officially opened. A Mayo Clinic Care Network ... as open, semi-private and private infusion rooms, oncology ... Center, hematology, rehabilitation center, a pain management program ...
(Date:7/30/2014)... 30, 2014  Dyadic International, Inc. ("Dyadic") (OTCQX: ... and proprietary technologies are used to discover, develop, ... the bioenergy, bio-based chemical, biopharmaceutical and industrial enzyme ... Dubinski as Vice President and Chief Financial Officer. ... and information technology operations for Dyadic and will ...
(Date:7/30/2014)... , July 30, 2014   Epic Sciences, ... and develops novel diagnostics to personalize and advance the ... of Gregory T. Lucier as chairman of ... and CEO of Life Technologies (formerly Invitrogen). Mr. Lucier ... Epic commercializes its circulating rare cell analysis platform with ...
(Date:7/30/2014)... July 30, 2014  RXi Pharmaceuticals Corporation ... company focused on discovering, developing and commercializing ... using RNA-targeted technologies, today announced that their ... for the reduction of recurrence of hypertrophic ... been initiated. Logo - ...
Breaking Biology Technology:Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5
... SAN DIEGO , June 2 Neurocrine Biosciences, Inc. (Nasdaq: ... Executive Officer of Neurocrine Biosciences, will be presenting at the Jefferies 2010 Global ... in New York . , ... The live presentation for the Jefferies conference takes place on Wednesday, June ...
... International ... ... 2010 -- The International Food Information Council (IFIC) 2010 “ Consumer Perceptions of Food ... consider its potential benefits for reducing the impact of food and food production on ...
... Repligen Corporation (Nasdaq: RGEN ) announced today that it will ... Wednesday, June 9th, 2010 , before the market opens.  The Company President ... conference call and webcast on the same day at 10:00 a.m. EDT ... Company. , , , ...
Cached Biology Technology:Neurocrine Biosciences to Present at the Jefferies 2010 Global Life Sciences Conference and the 9th Annual Needham Healthcare Conference 2Interest in Environment & Sustainability Prevails in Food Technology Survey 2Interest in Environment & Sustainability Prevails in Food Technology Survey 3Interest in Environment & Sustainability Prevails in Food Technology Survey 4Interest in Environment & Sustainability Prevails in Food Technology Survey 5Repligen Announces Conference Call of Fourth Quarter and Fiscal Year 2010 Financial Results 2Repligen Announces Conference Call of Fourth Quarter and Fiscal Year 2010 Financial Results 3
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
... This reagent has been developed ... for the reduction of nonspecific background ... Traditional methods describe blocking peroxidase with ... hydrogen peroxide in combination with additional ...
Rabbit polyclonal to Wilms Tumor Protein ( Abpromise for all tested applications). entrezGeneID: 7490 SwissProtID: P19544...
Biology Products: