Navigation Links
Vital step in cellular migration described by UCSD medical researchers

A vital molecular step in cell migration, the movement of cells within the body during growth, tissue repair and the body's immune response to invading pathogens, has been demonstrated by researchers in the University of California, San Diego (UCSD) School of Medicine. Published in the March 27 online edition of Nature Cell Biology and the journal's upcoming April print edition, the study describes how a the interaction of alpha4 integrin adhesion receptor with a protein called paxillin creates directional movement of a cell by inhibiting a protein called Rac.

"Understanding how this protein contributes to directional movement of a cell provides a new insight into cell migration and ultimately could lead to therapeutic interventions in autoimmune diseases such as multiple sclerosis and Crohn's disease," said the paper's first author Naoyuki Nishiya, Ph.D., a postgraduate researcher in the lab of senior author Mark Ginsberg, M.D., UCSD professor of medicine. "Since cell migration plays an important role in the immune response, as leukocytes move toward targets, a therapy that stops that movement could potentially help in autoimmune disorders where the body's immune system incorrectly attacks the body's own tissue."

From the genesis of human life to birth and beyond, cell migration is a complex, extremely important process that is not completely understood by researchers. In order to move, a cell must be polarized so that the molecular processes at the front end and back end are different, leading only to forward movement. One of the first steps in cell migration is the initiation of activity by Rac that extends protrusions out of the cell. These protrusions serve as tractor sites for migration as the cell moves toward its intended target. If Rac were active throughout the cell, it would extend protrusions in all directions, in essence keeping the cell in one place.

Until now, researchers have had limited understanding of the molecular mechanism
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Vital ocean prey play active role in environment
2. Scientists discover the cellular roots of graying hair
3. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
4. New study to explore cellular circuitry
5. Study provides insight into cellular defenses against genetic mutation
6. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
7. Liver cancer linked to cellular repair pathway
8. New cellular flaw found in some virulent breast cancers
9. Insects that produce males from unfertilized eggs reveal a surprising cellular feat
10. University of Minnesota researchers take new look at cellular suicide
11. RNA found in the cellular centrosome of surf clams
Post Your Comments:
(Date:9/29/2014)... Parents with children at home should use ventilation ... State University are recommending, after a new study showed ... asthma symptoms and chronic bronchitis. , "In homes where ... of asthma and wheezing is higher than in homes ... Ellen Smit, an associate professor in the College of ...
(Date:9/29/2014)... In order to support the world,s needs to ... and more, new and more efficient catalytic materials ... researchers, including several from Wayne State University, is ... new grant from the National Science Foundation. , ... of Multicomponent Materials for Electrocatalytic Cascade Reactions," was ...
(Date:9/29/2014)... Scientists at Washington State University have concluded that ... apples may help prevent disorders associated with ... to assess these compounds in apple cultivars grown ... edition of the journal Food Chemistry ., ... good source of these nondigestible compounds but there ...
Breaking Biology News(10 mins):Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3Wayne State research aims to develop new, more efficient catalytic materials 2An apple a day could keep obesity away 2
... off and you,re wondering why the surprising answer may ... a toddler. Surprising new research by University of Calgary, ... international journal, indicates a direct connection between an adult,s propensity ... Reimer is a leader in a growing field of study ...
... a child crying for more food at supper. Sadly, Margie ... at her family,s dinner table for years. Her daughter Maggie, ... means her body can,t tolerate anything more than a low-protein ... recessive genetic disease that is characterized by a deficiency in ...
... two sides of the brain causes it to become asymmetrical, ... . Asymmetry in the brain is thought to be important ... efficiently. Left-right asymmetry is present in the brains of ... early brain development. However, until now, scientists did not know ...
Cached Biology News:Early childhood diet may influence future health 2New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease 2New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease 3Game of two halves leads to brain asymmetry 2
(Date:10/1/2014)... 1, 2014  Spherix Incorporated (Nasdaq: SPEX) -- an intellectual ... monetization of intellectual property, announced today that the ... Uniden in the U.S. District Court for the ... has been rescheduled for November 10, 2014.  This ... The Court Order setting the Markman date was ...
(Date:10/1/2014)... 2014 In response to its ... address sales, training and consumer engagement challenges, ... mobile applications to turn their clients’ visions into ... customized mobile app creations, are now featured on ... partnership with Toyota, StudioPMG created a robust cross-platform ...
(Date:10/1/2014)... 01, 2014 The U.S. Department of ... Illinois University Edwardsville as part of the Trade Adjustment ... funding is co-administered by the Department of Labor and ... of Labor Thomas E. Perez and Secretary of Education ... job-driven training grants to nearly 270 colleges across the ...
(Date:9/30/2014)... news release is available in German . ... the Technische Universitt Mnchen (TUM) have demonstrated a new ... experiments show that future computer chips could be based ... As the main enabling technology of the semiconductor industry ... limits, the TUM researchers and collaborators at the University ...
Breaking Biology Technology:Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3
... (NYSE:,MON) today announced it will issue the company,s financial ... on Wednesday, Oct. 10, 2007, prior,to market open. ... central time (9:30,a.m. eastern time) in conjunction with the ... company,s results in the fourth-quarter and,fiscal-year 2007, as well ...
... Thermo Fisher,Scientific Inc. (NYSE: TMO ) announced that ... of 2007 before the market opens on Thursday,October 25, ... same day at 9:00,a.m. Eastern time. During the ... as well as future expectations. To listen, call 866-802-4321,within ...
... Oct. 5 Alfacell Corporation,(Nasdaq: ACEL ) today ... at 11 a.m. EDT on Monday, Oct. 15. During ... and Lawrence A. Kenyon,executive vice president, chief financial officer ... performance for the fiscal,fourth quarter and year ended July ...
Cached Biology Technology:Monsanto Company Sets Webcast and Analyst/Media Call for 2007 Fourth-Quarter and Fiscal-Year Financial Results 2Thermo Fisher Scientific to Hold Earnings Conference Call on Thursday, October 25, 2007 2Alfacell to Host Fiscal Fourth Quarter and Year-End 2007 Financial Results Conference Call and Webcast 2
Ps-Aeruginosa (IgA) -Ab EIA Sample Size: 100 l...
Request Info...
... bench time to just 15 minutes! The ... that can be drawn between this exciting new ... instant foods. Instant meals consumed by astronauts, ... and are reconstituted by adding water. The ...
...
Biology Products: