Navigation Links
'Virtual Patient' to simulate real-time organ motions for radiation therapy

With a $2 million grant from the National Institutes of Health (NIH), researchers from Rensselaer Polytechnic Institute are developing a physics-based virtual model that can simulate a patient's breathing in real time. When used in conjunction with existing 3-D models, adding the fourth dimension of time could significantly improve the accuracy and effectiveness of radiation treatment for lung and liver cancers.

X. George Xu, professor of nuclear and biomedical engineering, and Suvranu De, associate professor of mechanical engineering, have formed a multidisciplinary collaboration with clinical colleagues at the Cancer Therapy & Research Center in San Antonio, Texas, to develop the 4-D Visible Photographic Man (VIP-Man). This virtual model is an extension of Xu's ongoing project involving the 3-D VIP-Man, which is an advanced computer model that simulates in 3-D how radiation affects the organs and tissues in the human body.

"Live patients are not static beings, and a moving organ such as the lung or heart is a main concern in radiation treatment or imaging of tumors that are affected by such organ movement," Xu said. "In order to determine accurate and effective radiation dosages, doctors must consider such issues as the breathing function and air volume change that are affected by several physiological factors over the course of the radiation treatment."

Real-time simulations could allow doctors to spot the small fractions of time when the lungs, liver, kidneys, and eventually the heart, are stationary relative to the external radiation beams. These opportune moments during the actual therapy mean that doctors will have more confidence delivering the radiation to a moving tumor.

"The 4-D VIP-Man will allow doctors and medical physicists to accurately predict and monitor these anatomical changes to provide the most effective treatment possible at any given time," Xu said.

The fourth dimension of the VIP-Man is not easily achieved, according to Xu. Currently Xu and De are focusing their energy on respiratory function. "Using advanced computational tools, it is possible to simulate lung movement; however, not in real time," De said. "For effective radiation therapy, physics-based real-time performance offers the ultimate solution."

The key challenge in this project is to develop the algorithms that will make the virtual lungs and adjacent tissues move in real time according to realistic tissue biomechanical properties, De said.

Xu expects that the physics-based 4-D VIP-Man will eventually be used as an even more general anatomical modeling tool for the biomedical community to help patients with respiratory and cardiac diseases. At the same time, Xu will continue to work on the 3-D VIP-Man to create a "family" of virtual patients, ranging in ages and sizes, in collaboration with researchers worldwide through the Consortium of Computational Human Phantoms (http://www.virtualphantoms.org), co-founded by Xu.

The collaboration with the group in Texas came about when Xu's former student, Chengyu Shi, a clinical medical physicist, and Martin Fuss, a radiation oncologist, expressed their interests to develop better radiation treatment by accounting for lung movement. Xu contacted De, who had been using the 3-D VIP-Man to simulate tissue deformation for surgical procedures, and the idea to take 3-D VIP-Man into the fourth dimension was born.

Xu has been working on the 3-D VIP-Man since 1997 using the original Visible Human Project dataset provided by the National Library of Medicine, also funded by several grants from NIH as well as a National Science Foundation CAREER grant. The new four-year, $2 million grant is funded by the National Library of Medicine, which is part of NIH.
'"/>

Source:Rensselaer Polytechnic Institute


Related biology news :

1. Virtual autopsy helps identify drowning as cause of death
2. Whole-body MRI Takes Less Than 20 Min To Scan A Patients Entire Body For Cancer Spread To Bone
3. NYU researchers simulate molecular biological clock
4. Poplar trees redirect resources in response to simulated attack
5. Computational model simulates AZT metabolism in mitochondria
6. Surgeons with video game skill appear to perform better in simulated surgery skills course
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. LUCA technologies confirms real-time methane generation
9. Molecule by molecule, new assay shows real-time gene activity
10. Hopkins researchers develop new tool to watch real-time chemical activity in cells
11. Innovative movies show real-time immune-cell activity within tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/18/2016)... 18, 2016 --> ... ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance ... in the border security market and the continuing migration crisis ... Europe has led visiongain to publish this ... --> defence & security companies in the ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... 25, 2016 , ... The American Medical Informatics Association (AMIA) ... National Coordinator for Health IT (ONC) outlining a measurement approach to interoperability that ... when and where it was needed. The organization of health informatics professionals said ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on ... that Charles W. Stellar has been named by the WEDI Board of Directors as ... As an executive leader with more than 35 years of experience in healthcare, association ...
(Date:5/25/2016)... ... May 25, 2016 , ... Biohaven ... Administration (FDA) has granted the company’s orphan drug designation request covering BHV-4157 for ... designation granted by the FDA. , Spinocerebellar ataxia is a rare, debilitating ...
(Date:5/24/2016)... TEL AVIV, Israel , May 24, 2016   ... on providing physicians with artificial intelligence, real-time decision support tools ... selected to present at the 2016 Israeli Advanced Technology Industries ... part of Israel,s 15th National Life ... to 26th at the David Intercontinental Hotel in ...
Breaking Biology Technology: