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Virginia Tech scientists develop process for creating biocompatible fibers

Scientists at Virginia Tech have developed a single-step process for creating nonwoven fibrous mats from a small organic molecule ?creating a new nanoscale material with potential applications where biocompatible materials are required, such as scaffolds for tissue growth and drug delivery.

The research will be presented in the Jan. 20 issue of Science, in the article, "Phospholipid Nonwoven Electrospun Membranes," by Matthew G. McKee, a recent Ph.D. graduate in chemical engineering from Virginia Tech now at P&G, current chemistry students John M. Layman and Matthew P. Cashion, and chemistry professor Timothy E. Long, all at Virginia Tech.

"Phospholipids, which are the main component of cell membranes in the human body or in an apple are exquisite in terms of their ability to self-organize," said Long.

The researchers fabricated this natural compound into a sub micron fiber ?100 times smaller than a human hair. "It is the first demonstration that electrostatic spinning, or electrospinning, a polymer processing technique, can be used with a small molecule to produce a fiber. "Clothing fibers such as polyesters and nylons are composed of large molecules, macromolecules," Long said. "Now, we are fabricating fibers from small molecules ?ones with a low molecular weight."

Under the microscope, the resulting mat shows a porous nonwoven structure.

The researchers used a commercial product, lecithin, a natural mixture of phospholipids and neutral lipids. The materials will spontaneously organize into cylindrical or worm-like strands to form membranes.

McKee studied this self-assembly and conducted rheological experiments to fundamentally understand the association of small molecules, then he determined that once phospholipids form an entangled network they can be treated similarly to higher weight molecules and electrospun. The size of the mats is limited only by the amount of material, such as lecithin.

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Source:Virginia Tech


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