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Virginia Tech group adds tools to DNA-targeted anti-cancer drugs

e the system but will allow us to see such things as how the assembly enters cells and how much of the drug reaches the DNA," Brewer said. "It is a common practice in the medical field to use luminescent dyes to study cells, so pathology labs will have the equipment needed to monitor drug delivery.

Brewer is giving her invited talk, "Applications of mixed-metal supramolecular complexes in the development of chemotherapeutic and photodynamic therapy agents" (INOR 219), at 9:15 a.m. Monday Aug. 29, in room 145B of the Washington, D.C., Convention Center. She will talk about adding functionality to the group's supramolecular assemblies.

Co-authors of the research are Matthew T. Mongelli, of Maywood, N.J., post doctoral associate in chemistry; Virginia Tech chemistry undergraduate students Jerita Dubash, of Ashburn, Va., and Matthew Jeletic, of Centreville, Va., graduate students David F. Zigler, of Sterling, Ill., Julie Heinecke, of Powhatan, Va., and Ran Miao, of Zhangzhou City, China, and biology professor Brenda S. J. Winkel.

In addition, members of the Virginia Tech group are presenting several posters related to the photodynamic therapy research.

Three posters will be available from 7 to 9 p.m. Sunday, Aug. 28. Dubash will present "Time dependent photochemical studies of Rh centered mixed-metal supramolecular complexes which photocleave DNA" (INOR 136), co-authored by Mongelli, Winkel, and Brewer. Heinecke will present "Using 31P NMR and a phosphine tag to monitor stereochemistry and reactivity of Ru(II) light absorbing units in supramolecular assemblies" (INOR 133), co-authored by Mongelli and Brewer. And Zigler will present "Luminescence tagging of 2,2'-bipyridine complexes of Fe(II): Synthesis and metal binding studies of 4-[N-(2-anthryl)amido]-4'-methyl-2,2'-bipyridine" (INOR 141), co-authored by graduate students Mark Elvington and Jared Brown and Brewer.

At the SciMix poster session from 8 to 10 p.m. Monday, Aug. 29
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Source:Virginia Tech


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