Because Wolbachia are found in about 75 percent of the world's insects, the discovery could impact the development of virally delivered biocontrol tools for insects that transmit pathogens to humans or harm agriculture. It might also enable the design of alternative therapies for debilitating illnesses such as river blindness and elephantiasis, whose pathologies are caused by Wolbachia bacteria living in the parasitic worms associated with these diseases.
The new research, led by Seth Bordenstein, an Assistant Scientist in the MBL's Program in Global Infectious Diseases, shows that a virus known as WO-B interferes with Wolbachia's ability to cause cytoplasmic incompatibility, the reproductive manipulation of its insect host.
Until now, scientists believed the virus was somehow inducing this process. But viruses pirate cells to reproduce, often killing the cells as a result. So Bordenstein and his colleagues hypothesized that by preying on Wolbachia cells, the WO-B virus might reduce the incidence of cytoplasmic incompatibility in a host, not promote it.
Using DNA analysis and electron microscopy, the scientists quantified the number of WO-B viruses and Wolbachia cells in the testes of a common host: the fruit-fly-sized jewel wasp, Nasonia vitripennis. The researchers found that the virus was indeed associated with reduced bacterial growth. Then they bred the wasps and confirmed fe
Source:Marine Biological Laboratory