Navigation Links
Viral hitchhiker inhibits Wolbachia bacteria's ability to proliferate

Scientists studying the widespread symbiotic bacteria Wolbachia have long been interested in its ability to proliferate. One way it does this is by hijacking sperm of its insect hosts and genetically tricking them to bear more infected females, the only sex that transmits the bacteria. Now, a new study from the MBL (Marine Biological Laboratory), published in the May 18 issue of PLoS Pathogens, demonstrates that a virus common to Wolbachia cells may be a key inhibitor of the cellular process that allows Wolbachia to manipulate insect reproduction.

Because Wolbachia are found in about 75 percent of the world's insects, the discovery could impact the development of virally delivered biocontrol tools for insects that transmit pathogens to humans or harm agriculture. It might also enable the design of alternative therapies for debilitating illnesses such as river blindness and elephantiasis, whose pathologies are caused by Wolbachia bacteria living in the parasitic worms associated with these diseases.

The new research, led by Seth Bordenstein, an Assistant Scientist in the MBL's Program in Global Infectious Diseases, shows that a virus known as WO-B interferes with Wolbachia's ability to cause cytoplasmic incompatibility, the reproductive manipulation of its insect host.

Until now, scientists believed the virus was somehow inducing this process. But viruses pirate cells to reproduce, often killing the cells as a result. So Bordenstein and his colleagues hypothesized that by preying on Wolbachia cells, the WO-B virus might reduce the incidence of cytoplasmic incompatibility in a host, not promote it.

Using DNA analysis and electron microscopy, the scientists quantified the number of WO-B viruses and Wolbachia cells in the testes of a common host: the fruit-fly-sized jewel wasp, Nasonia vitripennis. The researchers found that the virus was indeed associated with reduced bacterial growth. Then they bred the wasps and confirmed fe wer incidences of cytoplasmic incompatibility in relation to the reduced presence of the bacteria and increased presence of the virus.

"We're excited about these findings because there is a great deal of interest in deciphering the genetic and cytological mechanisms of cytoplasmic incompatibility," says Bordenstein. "We know very little about the virus, but understanding and using it may pave the way for future strategies to control insect-borne diseases."


'"/>

Source:Marine Biological Laboratory


Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Viral protein influences key cell-signaling pathway
4. Viral protein helps infected T cells stick to uninfected cells
5. Viral fitness explains different resistance patterns to aids drugs
6. Viral genetic differences are possible key to HIV dementia
7. Viral marker of human migration suspect
8. Viral protein is an effective preventative against infection
9. A virus-like hitchhiker may trigger bacterial meningitis
10. Novel antiviral technology inhibits RSV infection in mice
11. Researchers find molecule that inhibits regrowth of spinal nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2016)... , Nov 15, 2016 Research and ... Global Forecast to 2021" report to their offering. ... ... USD 16.18 Billion by 2021 from USD 6.21 Billion in 2016, ... Growth of the bioinformatics market is driven by the ...
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... ... December 08, 2016 , ... From wearable devices that can ... sports. On Thursday, December 15th a panel of entrepreneurs, innovators and a Philadelphia ... at a Smart Talk session. Smart Talk will run from 8:30 – 10:30 ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... to control cells — optogenetics — is key to exciting advances in the ... art, spatially patterned light projected via free-space optics stimulates small, transparent organisms and ...
(Date:12/8/2016)... ... December 08, 2016 , ... KBioBox llc announced today ... demand KbioBox developed a sophisticated “3 click” gene dditing off target analysis program ... new website, https://www.kbiobox.com/ and powered by the company’s proprietary BioEngine. ...
(Date:12/8/2016)... 8, 2016 Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... developing and commercializing products to treat rare diseases where ... it will be hosting an Investor Webcast Event Friday, ... origins of innate defense regulators (IDRs) as a new ... mucositis and the recently announced and published Phase 2 ...
Breaking Biology Technology: