Navigation Links
Viral genetic differences are possible key to HIV dementia

equences from subjects with little or no cognitive deficit. "In other words," says Pillai, "there appears to be a particular HIV mutation that is associated with dementia." He cautions that this result is "suggestive, not conclusive," because of the study's small sample size.

This information "may be clinically relevant in terms of treatment," Pillai explains. "If we identify the quintessential neurotoxic variant of HIV, could we use that as a predictor of HIV dementia?" He says that such knowledge could also help care providers make "guided therapeutic decisions ?for example, the detection of particular viral genotypes may lead physicians to select for antiretroviral regimens that cross the blood-brain barrier into the CNS most efficiently." Or, he speculates, "we might actually try to design a drug to target these genetic variants that are responsible for the neurological damage."

Pillai notes that the issue of HIV dementia is particularly important in regions outside North America and Europe where state-of-the-art antiretroviral medications are not widely available and HIV infection frequently leads to dementia.

SFVAMC staff physician Joseph K. Wong, MD, associate professor of medicine at UCSF and senior author of the study, adds, "In addition to the implications of this new knowledge for the 40 million people infected with HIV, this study may also contribute to our general understanding of viral encephalitis," or brain inflammation caused by other viruses. "These results suggest that specific features of viral components themselves, and not just the immune response to viral infection, may be responsible for direct damage to the nervous system."

Pillai says that even though the study included almost 500 gene sequences, it is still exploratory: "We are now in the process of expanding this to a survey of 100 to 150 individuals."

The study's co-authors were Sergei L. Kosakovsky Pond, PhD, of UC San Diego; Yang Liu, P
'"/>

Source:University of California - San Francisco


Page: 1 2 3

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Viral protein influences key cell-signaling pathway
4. Viral protein helps infected T cells stick to uninfected cells
5. Viral fitness explains different resistance patterns to aids drugs
6. Viral hitchhiker inhibits Wolbachia bacterias ability to proliferate
7. Viral marker of human migration suspect
8. Viral protein is an effective preventative against infection
9. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
10. Scientists detect probable genetic cause of some Parkinsons disease cases
11. Mouse brain tumors mimic those in human genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Viral genetic differences are possible key HIV dementia

(Date:8/20/2014)... spiciness that is irresistible to some, but intolerable to ... their findings to develop a new drug candidate for ... inflammation or other problems. They reported their progress on ... in ACS, Journal of Medicinal Chemistry . , ... had pegged a compound called capsaicin as the active ...
(Date:8/20/2014)... of honeybees grows to about 4,000 members, it triggers ... building of a special type of comb used for ... from the Department of Neurobiology and Behaviour at Cornell ... reproductive cycle of honeybee colonies. The results are published ... Nature . , Reproduction isn,t always a honeybee ...
(Date:8/19/2014)... made to decrease China,s increasing caesarean section rate, suggests ... BJOG: An International Journal of Obstetrics and Gynaecology (BJOG) ... delivery rates in the world. Of 16 million babies ... the exact rate is not known, the current Chinese ... caesarean rates ranging from 36% to 58%. However, before ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3
... WASHINGTON, Sept. 26 2007 -- Consuming large amounts of ... used painkillers in the United States, could potentially cause ... in the Oct. 15 print issue of ACS Chemical ... could occur not only from drinking caffeinated beverages while ...
... said today that the discovery of 11 new animal and ... the importance of conservation efforts in the ancient tropical forests ... tropical forests of a region known as Vietnams Green Corridor, ... well as three other plants new to science and exclusive ...
... sensing the magnetic reference direction, have recently been found ... PNAS, 2004). Furthermore, studies investigating what parts of a ... their magnetic compass showed that the cryptochrome-containing neurons in ... et al., PNAS, 2005; Liedvogel et al., EJN, 2007) ...
Cached Biology News:Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage 2New animal and plant species found in Vietnam 2
(Date:8/20/2014)... Canada (PRWEB) August 20, 2014 Not ... that E&L studies should be performed late in the ... is known. But current regulatory trends suggest that, like ... on the rise. In recent years, multiple drug sponsors ... packages or address specific questions during phase I/II. It’s ...
(Date:8/20/2014)... ear could improve the health of your heart, researchers ... Leeds used a standard TENS machine like those designed ... the tragus, the small raised flap at the front ... canal. , The stimulation changed the influence of the ... signals that can drive failing hearts too hard. , ...
(Date:8/20/2014)... Bulgaria (PRWEB) August 20, 2014 ... was released today including improvements to the enterprise ... and connectors for Lucene, SOLR and Elasticsearch. This ... for this high performance triplestore – GraphDB™ was ... interested in deploying the only mature enterprise resilient ...
(Date:8/19/2014)... August 19, 2014 Shimadzu Scientific ... systems, Prominence-i and Nexera-i, adding to the company’s ... excellent functionality, an intuitive operating environment, and full ... more efficient workflow for conventional to ultra-high-speed analysis. ... intuitive and intelligent design so users can begin ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2'Tickling' your ear could be good for your heart 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... Corporation (NYSE:,DHR) announced that President and Chief Executive ... the J.P. Morgan Healthcare Conference in,San Francisco on ... audio will be,simultaneously webcast on http://www.danaher.com . ... for one week., Danaher Corporation is a ...
... China Technology,Development Group Corporation (Nasdaq: CTDC; "the Company" ... products and solutions focusing on,solar energy business in ... ceremony to showcase the first SnO2 production line ... 2007., Accompanied by Mr. Alan Li, our ...
... 3 Neogen Corporation,(Nasdaq: NEOG ) announced today ... 2008, which ended Nov. 30, increased 34% from the ... net income in the,quarter rose to $0.22 per share, ... income of $3,254,000 set another quarterly,record for the 25-year-old ...
Cached Biology Technology:CTDC Holds a Ribbon Cutting Ceremony to Showcase First SnO2 Production Line 2CTDC Holds a Ribbon Cutting Ceremony to Showcase First SnO2 Production Line 3Neogen Reports 34% Increase in Net Income, 23% Increase in Revenues 2Neogen Reports 34% Increase in Net Income, 23% Increase in Revenues 3Neogen Reports 34% Increase in Net Income, 23% Increase in Revenues 4Neogen Reports 34% Increase in Net Income, 23% Increase in Revenues 5
Sf21 Insect Cells (Live) in Max-XP Medium...
... The BioGenex Super Sensitive ... is a novel product ... non-biotin polymeric technology. This ... signal to noise ratio ...
Artisan™ Wash Solution (x 50) Additional Information: EU regulatory status: CE US regulatory status: IVD ...
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
Biology Products: