Navigation Links
Viral genetic differences are possible key to HIV dementia

The study of 18 HIV-positive subjects shows that HIV in the brain and central nervous system is genetically different from HIV that lives in the blood and peripheral tissues.

Moreover, serious cognitive impairment among the study subjects was correlated with the presence of a particular mutation in the HIV envelope gene.

The study appears in the July 2006 issue of Brain. It was led by Satish K. Pillai, PhD, a staff research associate at SFVAMC and a postdoctoral fellow at the University of California, San Francisco.

Pillai and his associates generated 456 nucleotide sequences of HIV from the blood and cerebrospinal fluid of the study participants. They chose to focus on the viral envelope gene, which interacts with receptors on the surfaces of host cells. "That's the gene that's most likely to vary between tissues, because it evolves rapidly and allows the virus to dock with different cell types," Pillai says.

According to Pillai, an analysis of the sequence data suggests that HIV is "genetically compartmentalized" between the central nervous system (CNS) and the blood, "which means that the virus is replicating in relative isolation in these tissues, with very little exchange of genetic information between the two populations."

The researchers also analyzed the sequences in search of a "genetic signature" common to the CNS-specific viruses in all 18 individuals, recounts Pillai. They found such a pattern, consisting of four amino acids, within a subregion of the viral envelope gene known as the V3 loop. "The identification of these signature mutations presents convincing evidence that HIV adapts to the local environment within the central nervous system and, moreover, that commonalities in this environment exist across individuals," he asserts.

Another mutation in the V3 loop appeared consistently in virus from study subjects who demonstrated the most severe cognitive impairment. This mutation was absent in s
'"/>

Source:University of California - San Francisco


Page: 1 2 3

Related biology news :

1. Viral DNA sequence a possible trigger for breast cancer
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Viral protein influences key cell-signaling pathway
4. Viral protein helps infected T cells stick to uninfected cells
5. Viral fitness explains different resistance patterns to aids drugs
6. Viral hitchhiker inhibits Wolbachia bacterias ability to proliferate
7. Viral marker of human migration suspect
8. Viral protein is an effective preventative against infection
9. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
10. Scientists detect probable genetic cause of some Parkinsons disease cases
11. Mouse brain tumors mimic those in human genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Viral genetic differences are possible key HIV dementia

(Date:7/10/2014)... major cities in New Mexico, nearly every public golf ... than precious potable water supplies. Across the U.S. Southwest ... courses receive treated effluent. Reusing the effluent increases the ... and homeowners alike fertilize their lawns during the growing ... New Mexico State University turfgrass expert has a new ...
(Date:7/10/2014)... 27, 2014  Pomerantz LLP has filed a ... or the "Company")(NYSE-MKT: PVCT) and certain of its ... District Court, Middle District of Tennessee ... a class consisting of all persons or entities ... December 17, 2013 and May 22, 2014, both ...
(Date:7/10/2014)... , July 1, 2014 Smart technology ... for convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay ... GOOG ), Apple Inc. (NASDAQ: AAPL ), ... (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ... announce that the second series of 30 second spots on ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... Waltham, Mass.How does inflammation, brought on by stress, affect aging? ... and economic crisis of an epidemic of neurologic diseases caused ... manage to keep a rosy outlook in the face of ... and a host of other questions are the focus of ...
... The Howard Hughes Medical Research Institute today announced that ... among 50 scientists nationwide to be appointed HHMI Early ... associate member of the Center,s Basic Sciences Division, and ... Center,s Human Biology and Public Health Sciences divisions, each ...
... 26, 2009 / b3c newswire / -Companies are using ... as a platform to launch new products. Under the ... discuss important topics such as KAM, value proposition and ... pressure in this fast changing landscape.  , Randi Altschul, ...
Cached Biology News:Living long, living well 2Two Hutchinson Center researchers named HHMI Early Career Scientists 2
(Date:7/11/2014)... , Not for release, publication or distribution (in whole ... to do so would constitute a violation of the relevant ... the "Company") (LSE: SHP, NASDAQ: SHPG ) notes ... a meeting with representatives of AbbVie. This statement ... approval of AbbVie. A further update will be ...
(Date:7/11/2014)... Research and Markets  has announced the ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is ... or RNA) into cells. This technology helps the cells ... protein metabolism by affecting the nuclear genes. The transfection ...
(Date:7/11/2014)... 11, 2014 BCC Research ( http://www.bccresearch.com ... POLYMERASE CHAIN REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS , the ... reached nearly $140 billion in 2013. This is estimated ... five-year compound annual growth rate (CAGR) of 28.6%. , ... interesting and exciting possibilities within the broader PCR field. ...
(Date:7/11/2014)... -- EPFL and the University of  Geneva ... John P. Donoghue . The American neuroscientist is to ... The new Wyss Center for Bio- and ... , has named as its director one of ... , founder of Brown University,s Institute for Brain Science, ...
Breaking Biology Technology:Shire plc - Statement re: Media Speculation 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3
... Personix , a business unit of ... a license agreement with Remettra, Inc. , which ... firm's payments system will be integrated with Personix' Health ... of paper checks and remittance advices. Payers who sign ...
... together so well because they know they share the same ... CEO of Alliant Energy said Thursday that chief ... at the hip" if information technology is to support a ... Thursday at the Fusion 2006 CEO-CIO Symposium produced ...
... Madison, Wis. Berbee Information Networks Corp. ... for the city of Cuyahoga Falls, Ohio, that allowed residents ... iSeries technology. , ,IBM gave the Madison company its annual ... processors to be turned on during peak periods to provide ...
Cached Biology Technology:CEOs and CIOs must be 'joined at the hip' 2CEOs and CIOs must be 'joined at the hip' 3
Apoptosis Detection Systems and Reagents...
... plastic feeding tubes for rodent oral gavage ... risk of perforation and trauma. Plus they ... cleaning and the risk of cross-contamination. ... 20ga Length: ...
Barcoded Slides, 5 Packs of 5 Slides (25/Case)...
...
Biology Products: