Navigation Links
Veterinary scientists explore poultry virus as cancer killer

Virologists in the Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM) at Virginia Tech are looking at how a genetically modified variant of Avian Newcastle disease virus (NDV) can treat human prostate cancer.

Dr. Elankurmaran Subbiah, assistant professor in the Department of Biomedical Sciences and Pathobiology, was awarded a prestigious research grant by the Department of Defense. This “Congressionally Directed Medical Research Program?award will support the exploration and hypothesis development for an innovative approach to treating prostate cancer.

Subbiah and his co-investigator, Dr. Siba K. Samal, associate dean, University of Maryland campus, received a $113,250 grant for their ongoing work using a genetically modified version of NDV to treat prostate cancer in humans.

Prostate cancer is the second most common type of cancer in men, according to the American Cancer Society (ACS). The ACS estimates there will be almost 219,000 new cases of prostate cancer reported in the United States in 2007.

According to Subbiah, the use of poultry viruses as cancer therapy poses no threat to humans and several other oncolytic viruses are currently being explored to treat cancer. However, Subbiah’s work is the first to alter Newcastle disease virus through a reverse genetic system to target prostate cancer specifically.

Reverse genetics is the process of generating a recombinant virus from cloned complimentary DNA (cDNA) copy of a viral genome, explains Subbiah. Through the reverse genetics system, recombinant viruses can be designed to have specific properties that make them attractive as biotechnological tools, live vaccines, and cancer therapeutics. This is achieved through the introduction of the desired changes in the cDNA, which are then transferred faithfully to the recombinant virus.

In the current investigation, Subbiah and his associates are altering the fusion protein of NDV to replica te only in the presence of prostate specific antigen (PSA), which is found exclusively in cancerous prostate cells.

Normal, healthy cells have an interferon antiviral system that activates upon infection with NDV thereby preventing replication of the virus, explains Dr. Subbiah. Cancer cells, however, have defective interferon antiviral systems, he said. NDV utilizes the defects to replicate in the diseased cells. The replication of NDV leads to the death of the cancer cell by a process called apoptosis - also known as programmed cell death or cell suicide- in the cell.


'"/>

Source:Virginia Tech


Related biology news :

1. Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases
2. Wisconsin scientists grow critical nerve cells
3. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
4. UAB scientists discover the origin of a mysterious physical force
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
7. U-M scientists find genes that control growth of common skin cancer
8. UCLA scientists transform HIV into cancer-seeking missile
9. RNA project to create language for scientists worldwide
10. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
11. To control germs, scientists deploy tiny agents provocateurs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2016)... --> --> ... Fingerprint Identification System Market by Component (Hardware and Software), ... Finance, Government, Healthcare, and Transportation) and Geography - Global ... expected to be worth USD 8.49 Billion by 2020 ... 2020. The transformation and technology evolution from the manual ...
(Date:2/3/2016)... , Feb. 3, 2016 ... the addition of the "Emotion Detection ... Machine Learning, and Others), Software Tools (Facial ... Areas, End Users,and Regions - Global forecast ... --> http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has ...
(Date:2/2/2016)... 2016 This BCC Research report provides ... reviewing the recent advances in high throughput ‘omic ... field forward. Includes forecast through 2019. ... and opportunities that exist in the bioinformatic market. ... as well as IT and bioinformatics service providers. ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... Conn. , Feb. 8, 2016  NanoViricides, Inc. (NYSE MKT: ... its CEO, Eugene Seymour , MD, MPH, will present information ... at the Waldorf-Astoria Hotel in New York City ... will be in the Windsor Room at 5:30PM EST. Registered attendees ... New York City . --> ...
(Date:2/6/2016)... ... February 06, 2016 , ... Contact:, Abby Mitchell, ... Excellence in Education Sponsors Teacher Training Program , Bite of Science Dinner Event ... Center for Excellence in Education (CEE) will sponsor a Bite of Science professional ...
(Date:2/5/2016)... SYDNEY , Feb. 5, 2016 Australian-US drug ... ), announced today the appointment of a new Chairman, Mr ... Bryce Carmine , effective immediately. James Garner ... an Executive Director and former Acting CEO, Mr Iain ... a Non-Executive Director. --> James Garner , has ...
(Date:2/4/2016)... ... February 04, 2016 , ... ... Club, takes place February 5-6 at the University’s student center, Kehr Union, ... such as workshops and competitions for ample networking, learning and collaborating opportunities. ...
Breaking Biology Technology: