Navigation Links
Variation in women's X chromosomes may explain differences among individuals, between sexes

The first comprehensive survey of gene activity in the X chromosomes of women has revealed an unexpected level of variation among individuals, according to new work by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and Pennsylvania State University.

The results may have important implications for understanding the differences in traits among women and between males and females, in terms of both health and disease, said Huntington Willard, Ph.D., director of the IGSP and the study's senior author. The findings also offer new insight into the basis for well-established differences between the sexes, he said.

Willard said that the extensive variation in gene activity in the sex chromosomes means that, in essence, there is not one human genome, but two -- male and female.

"We looked at the X chromosomes of 40 women and every one of them had a unique pattern of gene expression," Willard said. "All of that variation is completely unique to women. The X chromosomes of males are all the same in this regard."

Willard and study co-author Laura Carrel, Ph.D., of Penn State, reported their findings in the March 17, 2005, issue of Nature. The National Institutes of Health supported the research. In the same issue of Nature, more than 250 researchers including Willard and Carrel, reported the complete DNA sequence of the human X chromosome.

In animals, sexual identity is governed by sex chromosomes. In humans and other mammals, males have one X and one Y chromosome, while females have a pair of X's.

Many genes on the male Y chromosomes have been lost over evolutionary time, leaving the chromosome with fewer than 100 functional genes. In contrast, the X chromosome -- present in at least one copy in both sexes -- encodes more than 1,000.

More than 45 years ago, researchers discovered that genes on one copy of the female's X chromosome are switched off, a modification known as X inactivation
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Genetic Variation Visualization - From EMBL
2. Variation in HIVs ability to disable host defenses contributes to rapid evolution
3. Variation in bitter-taste receptor gene increases risk for alcoholism
4. Variations in detoxifying genes linked to Lou Gehrigs disease
5. Of mice and mens (and womens) contraceptives
6. Heavy smoking cuts womens chance of pregnancy -- even with donated oocytes
7. Scientists analyze chromosomes 2 and 4
8. Mouse to man: The story of chromosomes
9. Researchers use multiphoton microscopy to watch chromosomes in action
10. Short chromosomes put cancer cells in forced rest
11. Researchers attach genes to minichromosomes in maize
Post Your Comments:
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: ... but can,t remember your password, site key or the answer ... your first grade teacher? Today, Hoyos ... app that will finally put an end to the ... 1U TM . 1U leverages a user,s smartphone to ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... the discovery of the world,s first mass producible, low-cost, ... clay, would be a safer, more environmentally friendly replacement ... A report on the research appears in ACS, ... colleagues focused on a new organoclay developed and patented ...
... joyous event, but when a child is born too early, worrisome ... steep medical bills for the family. To address this, Johns Hopkins ... to pick up very early signs that a woman is going ... is 40 weeks, while babies born before 37 weeks gestation are ...
... 2010 (Vienna, Austria) -- Can HIV infection ever be ... infected persons was the topic of a high-level, two-day ... AIDS 2010, the biennial international conference of HIV researchers, ... Cure: HIV Reservoirs and Strategies to Control Them," brought ...
Cached Biology News:Students design early labor detector to prevent premature births 2Students design early labor detector to prevent premature births 3Students design early labor detector to prevent premature births 4Top scientists tackle the issue of HIV persistence 2
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 ... into law H.R. 83, the Omnibus and Continuing ... first time, made hydrocephalus a condition eligible to ... Programs (CDMRP) administered by the Department of Defense ... with its allies on Capitol Hill, is celebrating ...
(Date:12/24/2014)... The report expects global cell isolation and ... also provides a carefully analyzed data about the vital ... market. , Full Copy of Report @ http://bit.ly/1yUxy0T ... for cell expansion will keep witnessing growth at an ... to be driven by rapid technological advancements, government funding ...
(Date:12/24/2014)... LONDON , December 23, 2014 ... Review Algeria , out today and available for free ... the actors driving change and growth in the sector today. ... has scored notable successes has been in developing a homegrown ... 70 percent local production still remains some way off. A ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 The ... global leader of technical training across the life sciences ... Data Management (SCDM) to provide the organization's members ... programs —providing access to the more than 350 sessions ... members with 10% off when registering for a ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... CHICAGOEarlier this summer, we looked at venture capital funding ... which reached about $5 billion in investments in small ... the $5.4 billion invested during the fourth quarter of ... ,The results for the second quarter of 2004 were ...
... U.S. Rep. Jane Harman (D-Redondo Beach, Calif.) MADISON ... silly as that question is, it appears to be at ... of the 2004 presidential campaign. Both political parties will deserve ... to stem cell politics. , ,If you followed the Democratic ...
... more important to a manufacturing company: time or money? , ... Manufacturing , ruthlessly cutting down the time it takes to ... way to reduce costs and end up with more ... buying new equipment," Frank Rath, associate director of the center, ...
Cached Biology Technology:Midwest life science companies capture 3% of VC investments in Q.2 2Dividing stem cells along partisan lines isnt a good experiment 2Dividing stem cells along partisan lines isnt a good experiment 3University center offers speed boost to manufacturers 2
Microlite 2+ Plate, round bottom; an irradiated, high binding surface with enhanced dynamic range, extra high reflectivity and minimal cross talk for low signal luminescent reactions....
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
... ultimate tool for both microplate reader ... two editions of SkanIt Software available; ... in life science research, and a ... for compliance with FDA's 21 CFR ...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
Biology Products: