Navigation Links
Variation in bitter-taste receptor gene increases risk for alcoholism

verify that individuals with this variant also tend to be less sensitive to bitter tastes as suggested by the cell culture experiments.

As part of this investigation, Goate's team took advantage of available genome sequence databases to speed work in identifying and studying genes on chromosome 7. She says data from the Human Genome Project allowed the investigators to more quickly recognize individual variations in genes, called polymorphisms, that can influence how a gene product or protein functions.

As part of this study, Goate's team sequenced the TAS2R16 receptor gene in a number of individuals, but they didn't identify genetic variants they hadn't found already in the public databases.

The variant that increases risk of alcohol dependence was common in African Americans -- where about 45 percent of those studied carried this variation in the TAS2R16 receptor gene -- but rare in Caucasians -- where only 0.6 percent had this variation. Although the increased incidence of the variant means a larger percentage of African Americans are at risk because of this genetic factor, the variant in the TAS2R16 receptor also significantly increased risk in those Caucasians who carried the genetic variation.

The fact that this particular genetic variation is more common in African Americans does not necessarily mean African Americans will have a higher incidence of alcoholism. The difference in the TAS2R16 gene is only one of several genetic and environmental factors involved in risk for alcoholism, according to Goate.

"I don't think our result has any implications for the levels of alcoholism within different populations," Goate says. "We know that this polymorphism is more common in African Americans than in Caucasians, but the frequency of alcoholism still can be similar between the two groups because many genes and environmental factors influence risk."


'"/>

Source:Washington University School of Medicine


Page: 1 2

Related biology news :

1. Genetic Variation Visualization - From EMBL
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Variation in HIVs ability to disable host defenses contributes to rapid evolution
4. Variations in detoxifying genes linked to Lou Gehrigs disease
5. Activation of thermoreceptors mediates raw garlics burning pungency
6. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
7. Small worm yields big clue on muscle receptor action
8. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
9. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
10. Bats use touch receptors on wings to fly, catch prey, study finds
11. HIV accessory protein disables host immunity via receptor-protein intermediary
Post Your Comments:
(Date:9/2/2014)... in Taiyuan, China, have substantially improved the health of ... reduction in costs associated with loss of life and ... the Columbia Center for Children,s Environmental Health (CCCEH) at ... University, the Center of Diseases Control and Prevention of ... Health. , The study is the first to document ...
(Date:9/2/2014)... of lithographic limestone is well known as a ... that area (for example, Archaeopteryx). Now, for the ... the French equivalent of these outcrops - discoveries ... known water treader. , Despite the abundance of ... have been obtained from the Late Kimmeridgian equivalents ...
(Date:9/2/2014)... done in by it. New research at Rockefeller University ... gap in mice with very similar genetic backgrounds ... the development of psychiatric disorders such as anxiety and ... as it goes through its life. And we suspect ... genes, and as a result, affect an animal,s susceptibility ...
Breaking Biology News(10 mins):Clean air halves health costs in Chinese city 2Exceptionally well preserved insect fossils from the Rhône Valley 2Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3
... Cheryl Hayashi, a biologist at UC Riverside and a national ... a $500,000 MacArthur Fellowship, one of the most prestigious awards ... MacArthur Fellows for 2007 named by the John D. and ... award, the MacArthur Fellowship is a no strings attached grant ...
... help policy makers to estimate the consequences of various ... much toll must be charged for the desired policy ... all travellers or maximising the toll incomes (revenues). Based ... the impacts on road congestion and the total toll ...
... antimicrobials bind and thereby get inactivated in the mucus ... may have found a way to help cystic fibrosis ... this work has potential as a therapeutic strategy against ... professor of materials science and engineering, of physics, and ...
Cached Biology News:UC Riverside biologist receives prestigious MacArthur Fellowship 2UC Riverside biologist receives prestigious MacArthur Fellowship 3Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials 2
(Date:8/31/2014)... 31, 2014 2014 Market ... a professional and in-depth research report on ... Polyacrylamide information, including Polyacrylamide definition, classification, application, ... industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment ...
(Date:8/30/2014)... The Global and China Electrical ... study on the current state of the Electrical ... The report provides a basic overview of the ... Global market analysis and Chinese domestic market analysis ... trends and competitive landscape of the market. A ...
(Date:8/29/2014)... based on electrons, but one of the most promising ... circuits based on light (photons) instead of electrons. First, ... stream of single photons and control their direction. Researchers ... to achieve this control, but now scientists at the ... stream of photons emitted one at a time and ...
(Date:8/29/2014)... According to a new market report published by Transparency ... valued at USD 3,754.6 million in 2012 and is estimated ... CAGR of 5.9% from 2013 to 2019. , Nearly half ... by bone and joint disorders, and this number is expected ... will continue to increase the demand for orthobiologics. Other factors ...
Breaking Biology Technology:International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Breakthrough in light sources for new quantum technology 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... of Multi-Use Clearance for Axxent(R), System ... Radiation Therapy, SUNNYVALE, Calif., May 21 ... from the U.S. Food & Drug Administration,(FDA) for ... System for the treatment of endometrial cancer. Previously,cleared ...
... Co., Ltd. announced today,that it has entered into an ... a German biotechnology company focusing on research into,antibodies for ... 100 percent of the stock and make a,one-time payment ... Closure of the transaction is subject to clearance under ...
... world converge on Regenesis, SCOTTSDALE, Ariz., May ... that markets the Provant(R) Wound Therapy,System, announced today ... purpose is to guide advanced scientific investigations into ... and further,application of Regenesis, platform technology to clinical ...
Cached Biology Technology:FDA Clears New Applicators for Endometrial Cancer Treatment With Xoft's Axxent(R) Electronic Brachytherapy System 2FDA Clears New Applicators for Endometrial Cancer Treatment With Xoft's Axxent(R) Electronic Brachytherapy System 3FDA Clears New Applicators for Endometrial Cancer Treatment With Xoft's Axxent(R) Electronic Brachytherapy System 4Daiichi Sankyo Co., Ltd. Announces Acquisition of Biotech Firm U3 Pharma AG 2Daiichi Sankyo Co., Ltd. Announces Acquisition of Biotech Firm U3 Pharma AG 3Regenesis Biomedical Appoints Scientific Advisory Board Composed of Life Science and Electronics Experts 2Regenesis Biomedical Appoints Scientific Advisory Board Composed of Life Science and Electronics Experts 3
...
... Ferrofluid products perform optimally when ... Systems MagCellect Magnet. To accommodate ... iron boron permanent magnet holds ... mm test tubes or two ...
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Agarase cleaves agarose to neoagaro-oligosaccharides, and is used for,quantitative, gentle recovery of DNA from low melting point agarose....
Biology Products: