Navigation Links
Variation in bitter-taste receptor gene increases risk for alcoholism

A team of researchers, led by investigators at Washington University School of Medicine in St. Louis, has found that a gene variant for a bitter-taste receptor on the tongue is associated with an increased risk for alcohol dependence.The research team studied DNA samples from 262 families, all of which have at least three alcoholic individuals. The families are participating in a national study called the Collaborative Study of the Genetics of Alcoholism (COGA). COGA investigators report in the January issue of the American Journal of Human Genetics on the variation in a taste receptor gene on chromosome 7 called TAS2R16.

"In earlier work, we had identified chromosome 7 as a region where there was likely to be a gene influencing alcoholism risk," says principal investigator Alison M. Goate, D. Phil., the Samuel and Mae S. Ludwig Professor of Genetics in Psychiatry at Washington University. "There's a cluster of bitter-taste receptor genes on that chromosome, and there have been several papers suggesting drinking behaviors might be influenced by variations within taste receptors. So we decided to look closely at these taste receptor genes."

Because taste receptors tend to vary a lot in the general population, Goate and colleagues had the opportunity to look at a large number of differences in genetic sequences and determine whether certain sequences might influence risk. In this study, they concentrated on TAS2R16, which helps regulate the response to bitter tastes.

They found a single base variation in the TAS2R16 receptor gene that seemed to put people at an increased risk for alcoholism. In cell culture experiments, Goate found that the variant receptor produced by this gene was less responsive to bitter compounds.

"The more common variant is more sensitive to bitter tastes, and people with that variant had a lower risk of being alcohol dependent," Goate says.

Goate hopes to replicate these findings in human taste tests, to
'"/>

Source:Washington University School of Medicine


Page: 1 2

Related biology news :

1. Genetic Variation Visualization - From EMBL
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Variation in HIVs ability to disable host defenses contributes to rapid evolution
4. Variations in detoxifying genes linked to Lou Gehrigs disease
5. Activation of thermoreceptors mediates raw garlics burning pungency
6. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
7. Small worm yields big clue on muscle receptor action
8. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
9. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
10. Bats use touch receptors on wings to fly, catch prey, study finds
11. HIV accessory protein disables host immunity via receptor-protein intermediary
Post Your Comments:
(Date:8/17/2015)... , Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... sales campaign for Q4 2015. The new marketing campaign ... consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and ... is a leader in retail driven marketing and brand ...
(Date:8/12/2015)... As the digital payment services ... advanced biometrics technology is accelerating beyond expectations.  While the ... using their credit cards, the digital currency, mobile payment ... services led by companies in the space such as ... (NASDAQ: GOOG ), Apple Inc. (NASDAQ: AAPL ...
(Date:8/12/2015)... 12, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced that four of its fingerprint ID ... officially been named FIDO Certified™ by the Fast ... certification, Synaptics, Natural ID™ fingerprint solutions are fully ... (UAF) standard and are interoperable among other products ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... and spiders living in coastal salt marshes affected by the ... spill but were able to recover within a year if ... Houston study published Wednesday (March 7) in the open access ... first studies to look at how oil spills affect salt ...
... More than 99 percent of Antarctic blue whales were killed ... circumpolar genetic study of these critically endangered whales has found ... of some 2,200 individuals. That, says lead author Angela ... future recovery. Results of the study have just ...
... discovery in the deep sea. They found environments known as ... life thrives without sunlight. Then they found equally unique, ... on the ocean bottom. Could vents and seeps co-exist ... so. Until now. That,s exactly what researchers uncovered during ...
Cached Biology News:University of Houston study shows BP oil spill hurt marshes, but recovery possible 2Genetic survey of endangered Antarctic blue whales shows surprising diversity 2Genetic survey of endangered Antarctic blue whales shows surprising diversity 3Hot meets cold at new deep-sea ecosystem: 'Hydrothermal seep' 2
(Date:8/27/2015)... HUYA Bioscience International (HUYA) today announced the sponsorship ... of HTLV-1, held this week at the University of ... Society is to promote research on HTLV-1 and HTLV-1-associated ... and research related to these fields to advance science, ... proud to support this prestigious conference," said Mireille ...
(Date:8/27/2015)... TRIANGLE PARK, N.C. , Aug. 27, 2015 ... on the decision by FedEx, UPS and The ... of certain biological specimens classified as ,select agents, ... and long history of handling these sensitive shipments. ... knowledge of global transportation regulations, trained and certified ...
(Date:8/26/2015)... -- Roka Bioscience, Inc. (NASDAQ: ROKA ), a molecular ... the detection of foodborne pathogens, today announced that Paul ... Company Emerging Growth Conference on September 2 at 9:20am ... York Marriott Marquis. A live webcast ... relations section of Roka Bioscience,s website at http://rokabio.investorroom.com/ ...
(Date:8/26/2015)... , Aug. 26, 2015 Intrexon Corporation (NYSE: ... today the closing of its previously announced public offering ... the underwriters of their option to purchase an additional ... price of $41.00 per share.  The exercise of the ... common stock sold by Intrexon to 5,609,756 shares and ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4
... N.Y., June 14, 2011 Health Care Compliance ... healthcare compliance and competency training, today announced the release ... HIPAA for Business Associates (BAs) . Responding to ... vendors, HCCS has created an online course designed to ...
... TRIANGLE PARK, N.C., June 14, 2011 Bayer CropScience ... world,s top innovative crop science companies in the areas ... has announced the release of a video featuring the ... national award-winning program, Making Science Make Sense (MSMS) ...
... INVO Bioscience, Inc. (OTC BB: IVOB), a medical ... with infertility, today announced the completion of a 40 ... Results from this completed clinical study will be submitted ... purpose of gaining registration and approval for the sale ...
Cached Biology Technology:New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 2New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 3Bayer CropScience Releases Video About Making Science Make Sense Program At Durham Performance Learning Center 2Bayer CropScience Releases Video About Making Science Make Sense Program At Durham Performance Learning Center 3Bayer CropScience Releases Video About Making Science Make Sense Program At Durham Performance Learning Center 4Bayer CropScience Releases Video About Making Science Make Sense Program At Durham Performance Learning Center 5INVO Bioscience Announces Planned Submission To ANVISA For Brazilian Approval Following Completion of Clinical Trial 2INVO Bioscience Announces Planned Submission To ANVISA For Brazilian Approval Following Completion of Clinical Trial 3INVO Bioscience Announces Planned Submission To ANVISA For Brazilian Approval Following Completion of Clinical Trial 4
... The CultureWell cell culture systems provide ... cells for staining and imaging. Each ... with standard optical-quality coverslips in cell ... provided sterile and ready to use. ...
... 5 ml of DETACHaBEAD Mouse CD4, polyclonal ... T cells from Dynabeads Mouse CD4 (L3T4). ... cells from Dynabeads Mouse CD4 using DETACHaBEAD ... for any downstream application including flow cytometry, ...
CoverWell imaging chamber gasket with adhesive, one chamber, 20 mm diameter, 1.0 mm deep *set of 40* Cell Biology Imaging Tools and Accessories Microscope Slide Accessories...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Biology Products: