Navigation Links
Variation in HIV's ability to disable host defenses contributes to rapid evolution

One of the reasons HIV is so difficult to contain and treat is its rapid evolution. Understanding how host defenses and viral countermeasures contribute to that evolution is vital.

Host cells produce two proteins that mutate HIV DNA and interfere with the virus's ability to replicate. But HIV produces a protein, called Vif, that can disable the two defensive proteins.

Vif is full of variation, both in sequence and in function, according to a new study in PLoS Pathogens, and this could in turn potentially accelerate the evolution of HIV.

Within a single patient, some versions of Vif don't work at all; others counteract only one of the host's defensive proteins. "It's a leaky system," according to Paul D. Bieniasz, senior author of the study and associate professor at The Rockefeller University's Aaron Diamond AIDS Research Center.

Some variations in Vif only partially inactivate the defensive proteins that cause HIV to mutate, and might even promote further variation in the virus within patients. "This work elucidates new pathways which shape the evolution of the virus," says Viviana Simon, lead author of the study.

###

Citation: Simon V, Zennou V, Murray D, Huang Y, Ho DD, et al. (2005) Natural variation in Vif function can differentially impact APOBEC3G/3F neutralization: A potential role in HIV-1 diversification. PLoS Pathogens 1(1): e6


'"/>

Source:PLoS


Page: 1

Related biology news :

1. Genetic Variation Visualization - From EMBL
2. Variation in womens X chromosomes may explain differences among individuals, between sexes
3. Variation in bitter-taste receptor gene increases risk for alcoholism
4. Variations in detoxifying genes linked to Lou Gehrigs disease
5. “Nano-scissors?laser shows precise surgical capability
6. Enzyme shown to help protect genomic stability
7. Low level of extinction during ice age linked to adaptability
8. Two chemicals boost immune cells ability to fight HIV without gene therapy
9. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
10. Study shows humans have ability to track odors, much like bloodhounds
11. Locusts built-in surface analysis ability directs them to fly overland
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... (PRWEB) , ... September 20, ... ... recently published findings of a study examining the effects of exoskeleton-assisted walking ... spinal cord injury (SCI). The article, "Neuromechanical adaptations during a robotic powered ...
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, a leading independent ... the opening of an office in Taipei, Taiwan. This new location allows RoviSys ... developing new relationships in the region. Located in the Neihu area of Taipei, ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... group of funded early-stage tech companies. “Grit” author Angela Duckworth and her team ... the ic@3401 community is Cooley, an international law firm with decades of experience ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... ... an biological outbreak is about to be eliminated, said Lyle Probst, President, CEO ... FireflyDX™ technologies different than other pathogen detection solutions, Probst said, “Sample ...
Breaking Biology Technology: