Navigation Links
Variant prion protein causes infection but no symptoms

Abnormal prion proteins are little understood disease agents involved in causing horrific brain-wasting diseases such as Creutzfeldt-Jacob disease in people, mad cow disease in cattle and chronic wasting disease in deer and elk. Now, new research suggests that a variant form of abnormal prion protein--one lacking an "anchor" into the cell membrane--may be unable to signal cells to start the lethal disease process, according to scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

"This work provides novel insights into how prion and other neurodegenerative diseases develop and it provides tantalizing clues as to how we might delay or even prevent such diseases by preventing certain cellular interactions," notes NIAID Director Anthony S. Fauci, M.D. A paper describing the research was released online today by the journal Science. RML virologist Bruce Chesebro, M.D., directed the project. Other key co-authors from the Hamilton, MT, RML laboratory include Richard Race, D.V.M., and Gerald Baron, Ph.D. Their collaborators included Michael Oldstone, M.D., and Matthew Trifilo, Ph.D., of The Scripps Research Institute in La Jolla, CA, and Eliezer Masliah, M.D., of the University of California, San Diego (UCSD).

Drawing on experimental concepts first developed at RML a decade ago, the research team exposed two groups of 6-week-old mice to different strains of the agent that causes scrapie, a brain-wasting disease of sheep. Within 150 days of being inoculated with the natural form of scrapie prion protein, all 70 mice in the control group showed visible signs of infection: twitching, emaciation and poor coordination. In contrast, the scientists observed 128 transgenic mice--those engineered to produce prion protein without a glycophosphoinositol (GPI) cell membrane anchor--for 500 to 600 days and saw no signs of scrapie disease. Subsequent electron mic
'"/>

Source:NIH


Page: 1 2

Related biology news :

1. Strongest proof yet found for prion hypothesis
2. First technology to remove prions that cause vCJD from blood launched
3. Research into how prions act in the brain could hold the key to defeating diseases
4. Unweaving amyloid fibers to solve prion puzzles
5. New results validating Pall prion reduction filter disclosed at ISBT Congress
6. New evidence questions the simple link between prion proteins and madcow disease
7. Soil-bound prions that cause CWD remain infectious
8. Brittle prions are more infectious
9. Brown team finds crucial protein role in deadly prion spread
10. Scripps research study reveals structural dynamics of single prion molecules
11. Scientists identify prions infectious secret
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Variant prion protein causes infection but symptoms

(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. One major ... multimodal biometric systems. Multimodal biometric systems utilize more than ...
(Date:12/10/2014)... Baptist Medical Center today announced plans for a new medical ... $50 million capital project is part of a larger capital ... The medical education building will be located in the ... 525@vine in Wake Forest Innovation Quarter. Construction will begin immediately ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... Michigan have identified a new potential therapeutic target for ... therapy to statins. Scientists in the lab ... the action of a gene responsible for transporting a ... to remove cholesterol from the blood in mice. Trapping ...
... the Seventh Framework Programme (FP7) of the European Commission, ... countries, has received a 8M funding to enhance ... European ,biobanks,. The project represents the next ... and Biomolecular Resources Research Infrastructure), which was operational from ...
... the gene HER2 these are the big three markers ... Annual Meeting 2013 adds a fourth: androgen receptors. "This ... toward the addition of the androgen receptor as potential target ... breast cancer," says Jennifer Richer, PhD, investigator at the University ...
Cached Biology News:U-M researchers find new way to clear cholesterol from the blood 28 M € from EU to enhance access by scientists to the largest European 'biobanks' 2AACR news: Studies show increasing evidence that androgen drives breast cancer 2
(Date:1/23/2015)... 23, 2015 Portal Solutions , a ... on Microsoft Office 365 and SharePoint platforms , today ... program for being one of the region’s fastest-growing mid-sized companies ... growth. , “To be recognized a second year in ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data ... was a record-breaking year across the board for the company. ... Data Platform and our Smart Data solutions, our customers were ... which led to record growth for the company in 2014,” ...
(Date:1/22/2015)... Crystal Diagnostics (CDx) Xpress System, a rapid ... AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. coli ... to as STEC or the “Big-6”) as well as Escherichia ... per 325 g of raw ground beef and raw beef ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... research team at the University of Wisconsin-Madison will ... study the impact of digital media on youth culture, learning, ... support 24 national studies of different aspects of the digital ... MacArthur is actually trying to do, with this grant to ...
... program authorized by the Circuit Court of Wisconsin ... consumers and businesses that acquired Microsoft software ... nearly $224 million back to them as part of ... software giant. , ,The notices are the result of ...
... - For Milwaukee's forthcoming wireless Internet service, everything seems to ... has finalized a contract with Midwest Fiber Networks, LLC ... off the hook because Midwest Fiber will invest the $20 ... begun to install antennas in a demonstration area containing ...
Cached Biology Technology:UW gets $3M to explore educational gaming 2UW gets $3M to explore educational gaming 3Microsoft to distribute $224M as part of settlement 2Will wireless Internet bypass the central city? 2Will wireless Internet bypass the central city? 3Will wireless Internet bypass the central city? 4
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
... A.D. Smith et.al. (1997) • ... on current biochemistry & molecular ... 17,000 headwords. Entries give details ... processes in which they are ...
Edited by D.M. Gersten (1996) Provides comprehensive descriptions of the techniques available for analytical gel electrophoresis of proteins and offers clear step-by-step protocols for all of the m...
Biology Products: