Navigation Links
Variant prion protein causes infection but no symptoms

Abnormal prion proteins are little understood disease agents involved in causing horrific brain-wasting diseases such as Creutzfeldt-Jacob disease in people, mad cow disease in cattle and chronic wasting disease in deer and elk. Now, new research suggests that a variant form of abnormal prion protein--one lacking an "anchor" into the cell membrane--may be unable to signal cells to start the lethal disease process, according to scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

"This work provides novel insights into how prion and other neurodegenerative diseases develop and it provides tantalizing clues as to how we might delay or even prevent such diseases by preventing certain cellular interactions," notes NIAID Director Anthony S. Fauci, M.D. A paper describing the research was released online today by the journal Science. RML virologist Bruce Chesebro, M.D., directed the project. Other key co-authors from the Hamilton, MT, RML laboratory include Richard Race, D.V.M., and Gerald Baron, Ph.D. Their collaborators included Michael Oldstone, M.D., and Matthew Trifilo, Ph.D., of The Scripps Research Institute in La Jolla, CA, and Eliezer Masliah, M.D., of the University of California, San Diego (UCSD).

Drawing on experimental concepts first developed at RML a decade ago, the research team exposed two groups of 6-week-old mice to different strains of the agent that causes scrapie, a brain-wasting disease of sheep. Within 150 days of being inoculated with the natural form of scrapie prion protein, all 70 mice in the control group showed visible signs of infection: twitching, emaciation and poor coordination. In contrast, the scientists observed 128 transgenic mice--those engineered to produce prion protein without a glycophosphoinositol (GPI) cell membrane anchor--for 500 to 600 days and saw no signs of scrapie disease. Subsequent electron mic
'"/>

Source:NIH


Page: 1 2

Related biology news :

1. Strongest proof yet found for prion hypothesis
2. First technology to remove prions that cause vCJD from blood launched
3. Research into how prions act in the brain could hold the key to defeating diseases
4. Unweaving amyloid fibers to solve prion puzzles
5. New results validating Pall prion reduction filter disclosed at ISBT Congress
6. New evidence questions the simple link between prion proteins and madcow disease
7. Soil-bound prions that cause CWD remain infectious
8. Brittle prions are more infectious
9. Brown team finds crucial protein role in deadly prion spread
10. Scripps research study reveals structural dynamics of single prion molecules
11. Scientists identify prions infectious secret
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Variant prion protein causes infection but symptoms

(Date:5/23/2013)... Frontiers in Plant Science , ... gene content and promoter evolution among grasses , ... of stretches of DNA that undergo little change in ... not code for any proteins. Some of these evolutionarily ... to regulate the expression of other genes or the ...
(Date:5/23/2013)... at Emory University, along with partners at the ... million grant over four years to establish the ... Research Center: Understanding Lifetime Exposures). The grant is ... United States. , The HERCULES Center is ... Sciences (NIEHS) of the National Institutes of Health ...
(Date:5/23/2013)... unnecessarily undergo surgery or harsh treatments because science ... aggressive forms of the disease. Researchers at Case ... are developing technology that allows patients to safely ... treatments or take drastic measures. , The project ... professor of biomedical engineering at Case Western Reserve ...
Breaking Biology News(10 mins):Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3Emory, Georgia Tech receive first human exposome center grant in US 2Emory, Georgia Tech receive first human exposome center grant in US 3Using big data to identify prostate cancers and best treatments 2Using big data to identify prostate cancers and best treatments 3
... increasingly resistant to even the most modern antibiotics, researchers ... Medical Center (LA BioMed) report in the September issue ... uncovered in immune system molecules that defend against infection. ... present evidence that small proteins in the immune systems ...
... important new study from the Journal of Consumer Research explains ... and the popularity of healthier food. In a series of ... In fact, consumers chose beverages, side dishes, and desserts containing ... positioned as healthy. In our black and white view, ...
... are continuously happening in hospitals. One of these stories ... the World Journal of Gastroenterology because of its shining ... comfort to many families. It is about a ... Nagasaki University Hospital, Japan in 2004. This patient was ...
Cached Biology News:Researchers discover new strategies for antibiotic resistance 2You're likely to order more calories at a 'healthy' restaurant 2Clearance of hepatitis C viral infection after liver transplantation 2
(Date:5/24/2013)... The Oklahoma tornado left the state ... mayor of Moore, one of the heavily damaged towns, proposed ... from cnn.com. Reaching out to also be of help, My ... Shield to counter the looming mold problem. , The ... 2013, caused 24 deaths, My Cleaning Products shared. Ten of ...
(Date:5/23/2013)... , May 24, 2013 ... angefertigt – Bei der englischen ... , 91 % der Teilnehmer einer groß angelegten ... 20 % laut GINA [*] -Definition [1] als ... Menschen mit Asthma generell einer von vier Denkweisen zugeordnet ...
(Date:5/23/2013)... , May 23, 2013  BioScrip, Inc. (NASDAQ: ... present at the Jefferies 2013 Global Healthcare Conference to ... New York. Richard Smith ... Hai Tran , Chief Financial Officer, will present ... Daylight Time.   About BioScrip BioScrip, ...
(Date:5/23/2013)... 23, 2013 Patheon Inc ., ... to the global pharmaceutical industry, will host a complimentary ... to Testing” on Tuesday, June 4, 2013 at 11 ... are required to comply with regulations for cleaning validation. ... limited scientific underpinning and little evaluation of risk. ...
Breaking Biology Technology:Mayor of Oklahoma-Tornado-Impaired Town Proposes Storm Shelter Bill, My Cleaning Products Offers Complimentary Molderizer and Safe Shield to Help Victim with Looming Mold 2Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 2Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 3Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 4Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 5Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 6Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 7Patheon to Present on “Cleaning Validation: Science, Risk and Novel Approaches to Testing” 2
... disorders, DEERFIELD, Ill., Oct. 16 Baxter ... has signed an agreement with,Kaketsuken, the Chemo-Sero-Therapeutic Research ... to develop, manufacture and market,the recombinant protein ADAMTS13. ... a naturally occurring enzyme that plays a,critical role ...
... ... Renowned Investment Banker and Biotechnology Company Start-up Leader ... Stelios Papadopoulos, PhD Provides Keynote Address, BOSTON, Oct. ... Investor Conference, New,England,s largest biotechnology investor forum, will explore ...
... Rigel,Pharmaceuticals, Inc. (Nasdaq: RIGL ) today ... presentations at the AACR-NCI-EORTC,International Conference on Molecular Targets ... They will highlight drug discovery,efforts focused on significant ... like kinase 1 (PLK1) and Janus tyrosine kinase,2 ...
Cached Biology Technology:Baxter Adds Recombinant Protein to Specialty Therapeutics Portfolio 2Baxter Adds Recombinant Protein to Specialty Therapeutics Portfolio 3Baxter Adds Recombinant Protein to Specialty Therapeutics Portfolio 42007 Massachusetts Biotechnology Council MASS Opportunities Investment Conference Showcases Leading Growth Companies 22007 Massachusetts Biotechnology Council MASS Opportunities Investment Conference Showcases Leading Growth Companies 3Rigel to Present Research Programs at Scientific Conferences 2Rigel to Present Research Programs at Scientific Conferences 3
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Prostaglandin E2 Luminex Standard Product Lines: Unspecified...
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
... Highly efficient delivery of siRNA while ... Electroporate up to 96 samples simultaneously ... from cell harvest to post-electroporation incubation ... , Designed for use with ...
Biology Products: