Navigation Links
Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax

profloxacin twice daily for 14 days, beginning one to two hours after exposure. One group also received three doses of the licensed human anthrax vaccine (anthrax vaccine adsorbed) postexposure.

In the group that received ciprofloxacin but no vaccine, only four of nine monkeys, or 44 percent, survived the challenge. The animals remained healthy while on antibiotics but succumbed when the antibiotics were discontinued after 14 days. In contrast, all 10 monkeys that received 14 days of antibiotics plus vaccination survived when the antibiotics were discontinued. Thus, postexposure vaccination enhanced the protection afforded by 14 days of antibiotic prophylaxis alone, and completely protected all the animals against inhalational anthrax.

"This provides direct evidence that the combination of anthrax vaccine with a short course of antibiotics given postexposure can completely protect nonhuman primates from inhalational anthrax," said senior author Arthur M. Friedlander, M.D., of USAMRIID. "Our results also suggest that the appearance of an antibody response--after treatment with antibiotics alone or in conjunction with vaccination--might be useful in determining when antibiotics can be safely discontinued."

According to Friedlander, inhalational anthrax begins when anthrax spores are ingested into the deep recesses of the lung. When the spores germinate, they are transformed into vegetative cells that produce three components contributing to virulence--lethal toxin, edema toxin, and capsule. The capsule surrounds the vegetative cell and prevents it from being ingested by host white blood cells that would otherwise destroy it, thus allowing anthrax infection to progress. The toxins are thought to act mainly by damaging defensive cells called phagocytes, causing the immune system to malfunction. The organism then spreads unimpeded to all major organs of the body, causing tissue damage and death.

While most spores probably germinate wit
'"/>

Source:US Army Medical Research Institute of Infectious Diseases


Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. Live Recombinant Adenovirus Vaccine Technique Explored
3. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
4. NIAID Initiates Trial of Experimental Avian Flu Vaccine
5. Study Models Impact Of Anthrax Vaccine
6. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
7. Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
8. EuroVacc 02 HIV Vaccine Trial Begins
9. Active Vaccine Prevents Mice From Developing Prion Disease
10. New Vaccine To Be Used For First Time In Polio Outbreak Response
11. Boosting The BCG Vaccine To Beat Tuberculosis
Post Your Comments:
(Date:8/1/2014)... Journal of Nutrition Education and Behavior (JNEB) announces the ... awards, which were presented at the Society for Nutrition ... Local to Global," in Milwaukee, Wisconsin, June 28 ... authors of the best article and best GEM published ... the JNEB Journal Committee and Board of Editors. ...
(Date:8/1/2014)... -- LiveScan Service Provider Binary Biometrics is pleased to welcome Kevin ... will improve its mobile service capabilities and add more daily appointments, which will ... service several new cities such as, but not limited to, Daytona ... Deltona , Edgewater , Holly ... Beach , Oak Hill , Orange City ...
(Date:7/31/2014)... of bigeye tuna movements in the northwestern Atlantic Ocean ... Research Center at the University of Massachusetts Amherst, found ... geographical range with pronounced north-south movements from Georges Bank ... area off Cape Hatteras southwest of Bermuda for foraging. ... to study one of the most important commercial tuna ...
Breaking Biology News(10 mins):Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3
... Nov. 12, 2013 One of the most comprehensive ... today, demonstrating an unprecedented level of genetic variation that ... ovarian cancer. The study highlights potential new pathways for ... multiple disease sites may be required for effective targeted ...
... as clear as glass, or why bakers use sugar, even ... in the American Chemical Society,s (ACS,) latest Bytesize Science ... . "Everything that happens in the kitchen is science," ... of it, you,re going to have more power over your ...
... protein, they tend to eat a small amount at ... at dinner. New research presented today at The ... eating high protein sausage and egg-based breakfasts curbed hunger ... and syrup) or skipping breakfast, in 18-55-year-old women., ...
Cached Biology News:Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment 2Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment 3
(Date:8/1/2014)... 01, 2014 Chantel Lee ’15 and Eli ... 10 40-hour weeks with Dr. Juan Rodriguez, Professor of Physics, ... a common diabetic eye disease caused by changes in the ... and Eli accomplished is quite remarkable,” said Rodriguez. “They took ... when they started, and together carried it to near completion ...
(Date:8/1/2014)... August 01, 2014 This is a ... the Ammonium Bicarbonate industry in Global and China. The ... definitions, applications and industry chain structure. Global market analysis ... focus on history, developments, trends and competitive landscape of ... situation is also offered. , The report also focuses ...
(Date:8/1/2014)... MD (PRWEB) August 01, 2014 ... RFID Solutions provider, today officially announces the opening ... prestigious Boji Science Park, Baoshan District in Shanghai, ... Shanghai is under the management of Mr. Shen ... , In the past three years, RURO’s has ...
(Date:8/1/2014)... CHICAGO , Aug. 1, 2014 AACC, ... better health through laboratory medicine, unveiled an updated brand ... laboratory professionals adapt to the changing healthcare environment and ... insight to physicians, so patients get the care they ... make up AACC,s membership play an essential role in ...
Breaking Biology Technology:Two Centenary College Students Tackle Diabetic Retinopathy Research 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 2Ammonium Bicarbonate Market in Internations & Chinese Regions Research Analysis Now Available at DeepResearchReports.com 3RURO Opens Office in Shanghai, China 2AACC Debuts Refreshed Brand Identity 2
... BioMarin Pharmaceutical,Inc. (Nasdaq: BMRN ) today announced that ... on February 27, 2009. Dr. Kakkis has,decided to leave his ... more of his time to personal endeavors related to rare diseases. ... for the foreseeable,future. , "I ...
... ANN ARBOR, Mich., Nov. 21 MichBio, the ... professionals,and service providers to its fourth annual Expo ... Rock Financial ShowPlace in Novi, MI. The ... bioscience industry professionals.,In addition, this year,s event attracted ...
... Eli Lilly and,Company (NYSE: LLY ) and ImClone ... completion of the previously announced tender offer,by Lilly,s wholly-owned subsidiary, ... price of $70.00 per share in cash. The,offer expired ... The depositary for the ...
Cached Biology Technology:BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 2BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 3BioMarin Announces the Planned Retirement of Dr. Emil Kakkis, Chief Medical Officer 4MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 3Lilly Completes Cash Tender Offer for ImClone Systems 2Lilly Completes Cash Tender Offer for ImClone Systems 3
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
Anti-BAR Immunogen: Peptide of aa 3-21 from human Bar Available Date: 38226...
... the HECT protein, E6-AP and ... suggests that this E2 is ... of non-""N-end rule"" protein substrates ... proteins as well as the ...
Anti-Mouse D011.10 TCR, Biotin (Clone KJ1-26) (mouse IgG2a)...
Biology Products: