Navigation Links
VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells

Researchers at the Virginia Commonwealth University Massey Cancer Center have found a new signaling component that influences movement of human breast cancer cells toward epidermal growth factor.

In the August issue of the Journal of Biological Chemistry, researchers showed that epidermal growth factor, which plays a critical role in breast cancer progression, stimulates sphingosine kinases - SphK1 and SphK2 - a family of enzymes that forms the potent lipid mediator, sphingosine-1-phosphate, and that breast cancer cells are unable to move without these kinases.

"If we understood how tumor cells spread or metastasize, we would be able to design better tools to help treat cancers," said lead author Sarah Spiegel, Ph.D., chair and professor in the VCU Department of Biochemistry and co-leader of the Massey Cancer Center Cell Signaling program.

Spiegel, who is internationally recognized for her pioneering work on new lipid mediators that regulate cell growth and cell death, and her colleagues, first discovered the role of sphingosine-1-phosphate in cell growth regulation nearly a decade ago. While researchers know that SphK1 is stimulated by multiple growth factors, less is known about how SphK2 is regulated. Spiegel and her team are continuing this work to better understand the functions of these enzymes.

"Our work suggests that sphingosine kinases are potential new targets in cancer therapy," she said.


'"/>

Source:Virginia Commonwealth University


Page: 1

Related biology news :

1. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
2. VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
3. Massey researchers induce cell death in leukemia
4. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
5. Jump-starting T Cells In Skin Cancer
6. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
7. Fox Chase Cancer Center scientists identify immune-system mutation
8. Breakthrough Microarray-based Technology for the Study of Cancer
9. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
10. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
11. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
Post Your Comments:
(Date:4/17/2014)... honored Clemson professor Rajendra Singh Thursday as a ... and expand solar deployment in the residential, commercial ... Banks Professor of Electrical and Computer Engineering and ... considered a local hero leading the charge across ... in solar power and driving policy changes at ...
(Date:4/17/2014)... honeybees in Europe, Asia and the United States are ... be impacting native honeybee populations at this time, according ... include including Nosema microsporidia and Varroa ... resilient to these invasive pests, which suggests to us ... Asia and the United States currently are not necessary ...
(Date:4/17/2014)... Researchers in France have hit on a novel ... receive the correct and most effective treatment possible., ... the western and developing world. If left untreated, ... to renal failure and other complications. In many ... problem. Clearly a more effective pathological approach to ...
Breaking Biology News(10 mins):White House honors Clemson professor as 'Champion of Change' for solar deployment 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... throughout the world and ensuring safe water supplies would do ... any other possible measure, according to an analysis released today ... water and sanitation reduces poverty in three ways. ... entrepreneurs; , Significant savings are achieved in the ...
... Researchers have discovered a mechanism for the rapid growth seen ... The tumors, which are made up of proliferating blood ... descent, with girls more frequently afflicted than boys. The ... blood-red lump on the head or facethen grow rapidly in ...
... Missouri Botanical Garden in St. Louis operates one of ... and the second largest in the western hemisphere. With ... a gigantic new aroid species from Ecuador, the ... has reached a milestone of six million specimens. ...
Cached Biology News:Providing toilets, safe water is top route to reducing world poverty: UN University 2Providing toilets, safe water is top route to reducing world poverty: UN University 3Providing toilets, safe water is top route to reducing world poverty: UN University 4Providing toilets, safe water is top route to reducing world poverty: UN University 5Researchers identify Achilles heel of common childhood tumor 2Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen 2Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen 3
(Date:1/14/2014)... and BETHESDA, Md. , ... joining together with two institutes from the National Institutes ... tools for bringing safer, more effective treatments to patients ... National Center for Advancing Translational Sciences (NCATS) and the ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
(Date:1/14/2014)... Washington, USA, and Cardiff, UK (PRWEB) January 13, 2014 ... photonics technology development leader with more than 20 years ... society for optics and photonics . Hainsey will serve ... are delighted to have Dr. Hainsey join SPIE as ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... Genzyme Corp. said on Wednesday it has agreed ... Wisconsin-Madison biotech spinoff, for $600 million in cash. , ,Bone ... more than $2 billion and almost 7,000 employees worldwide, plan ... companies recently reported healthy quarterly profits and revenues. Bone Care ...
... a new copy machine for $57,000. , ,The Z-Corp ... typical office copier: It makes three-dimensional models of small structures ... , ,Using white polymer powder and colored inks, the printer ... a time. Z-Corp is headquartered in Burlington, Massachusetts. , , ...
... can submit executive summaries of their businesses for angel ... May 9. , ,The Wisconsin Angel Network ... investor networks with entrepreneurs based on the investors' market ... a deal-flow pipeline, has been designed to be a ...
Cached Biology Technology:Massachusetts firm to buy UW spinoff Bone Care for $600 million 2Massachusetts firm to buy UW spinoff Bone Care for $600 million 3Start-ups, angels can connect on new state Web site 2Start-ups, angels can connect on new state Web site 3
...
... Multidizer is designed with a variety of ... - all in one unit. Shake, rock, ... operating compartments allow for hybridization and blotting ... , The upper chamber uses a ...
... sleek design loaded with class-leading features, the 1400 Series ... work is safe and consistent every time you use ... 1400 Series reduces power consumption by as much as ... over the life of the cabinet. Multiply this ...
... Concentrator, the SPD series takes the 'Classic' ... twist., The SPD121P SpeedVac comes equipped with ... runs; preventing samples from freezing; and allowing ... end-users preset level., Standard features on the ...
Biology Products: