Navigation Links
Using nature's most primitive anti-viral defense system to find new approaches to cancer research

The humble fruit fly and a grant from the AICR ?the Association for International Cancer Research - are helping a leading scientist in London identify potential targets for drugs that block the spread of cancer.

In one of the first studies of its kind, Dr Buzz Baum of the UCL Branch of the global Ludwig Institute for Cancer Research (LICR) is using the tiny fruit fly, Drosophila, as a simple genetic system in which to identify genes that may impact on the spread of human cancer cells.

He explains: "Long ago a cellular defence system evolved in our single-celled ancestors to protect them from viruses. This system, called RNAi, is still present today in humans, plants and animals. Recently, we have learnt how to harness this anti-viral system, so that we can use it to silence the function of any normal or mutant gene at will. This new technology has the potential to change forever the way researchers and doctors fight cancer and other diseases.

"By combining the benefits of Drosophila RNAi screens with the functional analysis in human cell culture models of metastasis, we expect to identify novel, conserved proteins involved in cell migration and invasion, some of which could prove to be good anti-cancer drug targets."

According to Dr Mark Matfield, AICR's scientific adviser: "Metastasis of tumours (the spread of cancer cells around the body) is the cause of mortality in the majority of human cancers and it is a complex, multi-step process. Understanding the molecular mechanisms that underlie each stage is therefore an important goal for cancer scientists. Dr Baum's research builds on his earlier work when, in collaboration with others, he completed a full study of the function of every one of the fruit fly's genes in cells. This is allowing him now to compare those to similar genes in human cell lines to help him understand why some cancer cells invade and spread to other parts of the body."

Derek Napier, AICR's Chief Exe cutive says the grant awarded to Dr Baum and worth £136,000 has been given in line with the charity's policy of funding the most exciting and novel approaches to research worldwide. "We believe it important to fund work that pushes the boundaries of science, and Dr Baum and his team are charged with tackling one of the greatest scientific challenges of all."
'"/>

Source:Ludwig Institute for Cancer Research


Related biology news :

1. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
2. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
3. Researchers Closer To Helping Hearing-Impaired Using Stem Cells
4. Using nanoparticles, in vivo gene therapy activates brain stem cells
5. Using computers and DNA to count bacteria
6. Using the genomic shortcut to predict bacterial behavior
7. Using dental X-rays to detect osteoporosis
8. Using brain scans, researchers find evidence for a two-stage model of human perceptual learning
9. Using nanomagnets to enhance medical imaging
10. The circadian clock: Understanding natures timepiece
11. Researchers create functioning artificial proteins using natures rules

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... , ... June 23, 2016 , ... In a new ... in Denmark detail how a patient who developed lymphedema after being treated for breast ... results could change the paradigm for dealing with this debilitating, frequent side effect of ...
(Date:6/23/2016)... -- Andrew D Zelenetz , ... Published recently in Oncology & ... Andrew D Zelenetz , discusses the fact ... placing an increasing burden on healthcare systems worldwide, ... the patents on many biologics expiring, interest in ...
Breaking Biology Technology: