Navigation Links
Using nanoparticles, in vivo gene therapy activates brain stem cells

brid, organically modified silica (ORMOSIL), the structure and composition of which allow for the development of an extensive library of tailored nanoparticles to target gene therapies for different tissues and cell types.

A key advantage of the UB team's nanoparticle is its surface functionality, which allows it to be targeted to specific cells, explained Dhruba J. Bharali, Ph.D., a co-author on the paper and post-doctoral associate in the UB Department of Chemistry and UB's Institute for Lasers, Photonics and Biophotonics.

While they are easier and faster to produce, non-viral vectors typically suffer from very low expression and efficacy rates, especially in vivo.

"This is the first time that a non-viral vector has demonstrated efficacy in vivo at levels comparable to a viral vector," Bharali said.

In the UB experiments, targeted dopamine neurons -- which degenerate in Parkinson's disease, for example -- took up and expressed a fluorescent marker gene, demonstrating the ability of nanoparticle technology to deliver effectively genes to specific types of cells in the brain.

Using a new optical fiber in vivo imaging technique (CellviZio developed by Mauna Kea Technologies of Paris), the UB researchers were able to observe the brain cells expressing genes without having to sacrifice the animal. Then the UB researchers decided to go one step further, to see if they could not only observe, but also manipulate the behavior of brain cells.

Their finding that the nanoparticles successfully altered the development path of neural stem cells is especially intriguing because of scientific concerns that embryonic stem cells may not be able to function correctly since they have bypassed some of the developmental stages cells normally go through.

"What we did here instead was to reactivate adult stem cells located on the floor of brain ventricles, germinal cells that normally produce progeny that then die if they are not u
'"/>

Source:University at Buffalo


Page: 1 2 3

Related biology news :

1. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
2. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
3. Researchers Closer To Helping Hearing-Impaired Using Stem Cells
4. Using computers and DNA to count bacteria
5. Using the genomic shortcut to predict bacterial behavior
6. Using natures most primitive anti-viral defense system to find new approaches to cancer research
7. Using dental X-rays to detect osteoporosis
8. Using brain scans, researchers find evidence for a two-stage model of human perceptual learning
9. Using nanomagnets to enhance medical imaging
10. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
11. Columbia research lifts major hurdle to gene therapy for cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Using nanoparticles vivo gene therapy activates brain stem cells

(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
(Date:4/2/2015)... April 2, 2015 In ... by far outperforms the strongest competitors, showing outstanding ... accuracy, the system is capable of a throughput ... proves up to be ten times faster than ... runner-up performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... 17, 2009 Representatives of the nation,s leading public ... and other Members of Congress, today announced the launch ... research and related activities that have been made possible ... (ARRA), also known as the stimulus. The ...
... be as intelligent as much bigger animals, despite only ... scientists at Queen Mary, University of London. "Animals ... to Lars Chittka, Professor of Sensory and Behavioural Ecology ... of Cambridge colleague, Jeremy Niven. This begs the important ...
... Two University of New Hampshire assistant professors ... Early Career Development (CAREER) grants. Vaughn Cooper of ... received $1 million to better understand beneficial mutations ... data collection. Christopher White of the mechanical engineering ...
Cached Biology News:Members of Congress, university leaders, scientists launch ScienceWorksForUS 2Members of Congress, university leaders, scientists launch ScienceWorksForUS 3Members of Congress, university leaders, scientists launch ScienceWorksForUS 4Bigger not necessarily better, when it comes to brains 22 UNH faculty receive $1.4M in CAREER grants from NSF 2
(Date:4/24/2015)... April 24, 2015 Leading Regenerative ... in its allogeneic stem-cell product development program and ... reflect the corporate strategic direction. , “I am ... adipose stem cell development program has been kicked ... cGMP manufacturing facility and hiring of our new ...
(Date:4/24/2015)... , April 24, 2015 /CNW Telbec/ - Mirego, leader in ... the making of three mobile app extensions for the all ... for its clients, Familiprix, OMSignal and MediaMiser, these extensions will ... to functions designed specifically for wrist use.  ... Watch is a highly customizable tactile smartwatch that makes for ...
(Date:4/23/2015)... 2015 Ralco announced today that it ... (ABN) for the exclusive worldwide rights to sell and ... is a new in-line milk system that increases the ... to move supplementation milk cups within a farrowing facility ... technology lets producers get Birthright™ milk to the right ...
(Date:4/23/2015)... -- BioTE Medical President and Founder Gary Donovitz ... - Avoiding Over-Medication through Natural Hormone Balance" (ISBN: 9780990706458) ... at JW Marriott / Ritz Carlton Grande Lakes April ... Happier, is a welcomed response to many men and ... higher quality of life thanks to bio-identical hormone replacement ...
Breaking Biology Technology:Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Ralco Acquires License to Birthright™ Moveable Milk Cup 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3
... Talent Management Vendor,s Model ... Market, OTTAWA, Feb. 26 /PRNewswire/ - Halogen Software ... management software,today announced that FactPoint Group has profiled Halogen ... market. The Silicon Valley based research and,consulting firm selected ...
... Inc., a company focused,on developing novel therapies targeting ... Bussineau, Ph.D., to the,position of vice president of ... vice president, business development and nonvascular,operations., "Dr. ... experience to,BioVascular that will allow us to advance ...
... Ambrx Inc. today announced the,appointment of Douglas ... Clinical Research and Development., Axelrod joins Ambrx ... Procter & Gamble Pharmaceuticals. Most recently, he served ... and Product,Development where he accelerated the discovery process, ...
Cached Biology Technology:FactPoint Group Recognizes Halogen for "On-Choice" Deployment Model 2BioVascular, Inc. Expands Executive Team 2Ambrx Appoints Douglas Axelrod Senior Vice President for Clinical Research and Development 2
... Sphingobeads are designed for ... and characterize sphingosine binding proteins. ... 1 mL of agarose beads ... bound through the terminus of ...
... PolarScreen Androgen Receptor (AR) Competitor Assay Kits ... studying and screening potential AR ligands using ... AR ligand binding domain protein tagged with ... novel, selective fluorescent androgen ligand (Fluormone AL ...
... Plus is a chemiluminescent signal enhancing ... to boost the signal obtained with ... kits. ChemiLucent™ Plus is derived from ... conjugated complex- or chemiluminescent substrate enhancers, ...
... proteomic scale kinase profiling, quantitative measurement ... discovery research built on the flexible ... platform. These microarrays are available as ... Substrate - Peptide Microarray Service. ...
Biology Products: