Navigation Links
Using nanomagnets to enhance medical imaging

Nanoscale magnets in the form of iron-containing molecules might be used to improve the contrast between healthy and diseased tissue in magnetic resonance imaging (MRI)—as long as the concentration of nanomagnets is carefully managed—according to a new report* by researchers at the National Institute of Standards and Technology (NIST) and collaborators. Molecular nanomagnets are a new class of MRI contrast agents that may offer significant advantages, such as versatility in design, over the compounds used today.

Contrast agents are used to highlight different tissues in the body or to help distinguish between healthy and diseased tissue. NIST is working with two universities and a hospital to design, produce and test nanomolecules that might make MRI imaging more powerful and easier to perform. The new paper resolves a debate in the literature by showing that iron-containing magnets just two nanometers wide, dissolved in water, do provide reasonable contrast in non-clinical MRI images—as long as the nanomagnet concentration is below a certain threshold. (A nanometer is one billionth of a meter.) Previous studies by other research groups had reached conflicting conclusions on the utility of molecular nanomagnets for MRI, but without accounting for concentration. NIST scientists, making novel magnetic measurements, were able to monitor the molecules' decomposition and magnetic properties as the composition was varied.

The injectable dyes currently used as MRI contrast agents are of two types. Magnetic ions, which alter the nuclear properties of hydrogen in water, offer the advantage of consistent identical design but provide low contrast. The second category encompasses particles of thousands of atoms or crystals, which alter local magnetic fields; they provide contrast variation in a larger region but have irregular designs and magnetic properties that are difficult to control. By comparison, molecular nanomagnets can be designed to have consistent properties and high contrast. In addition, they might be modified to act as "smart" materials whose contrast could be turned on only when bonded to a target molecule or cell. Toxicity is not believed to be an issue, because iron is naturally found in the body and other studies have found that these materials are non-toxic at the concentrations used in MRI.

NIST works with Florida State University to make single-molecule magnets less than five nanometers (nm) in diameter, and works with the University of Colorado at Boulder to make nanocrystals in the 10-50 nm range. The agency is pioneering methods for manipulating and measuring the magnetic properties of these compounds and is developing instrumentation for understanding how contrast agents work and how to control contrast properties. Researchers correlate the measured properties to the observed MRI response under non-clinical conditions using imagers at The Children's Hospital in Denver. The information gained is fed back into recipes for making even better nanomagnets. The work described in the new paper was supported in part by the National Science Foundation.


'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
2. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
3. Researchers Closer To Helping Hearing-Impaired Using Stem Cells
4. Using nanoparticles, in vivo gene therapy activates brain stem cells
5. Using computers and DNA to count bacteria
6. Using the genomic shortcut to predict bacterial behavior
7. Using natures most primitive anti-viral defense system to find new approaches to cancer research
8. Using dental X-rays to detect osteoporosis
9. Using brain scans, researchers find evidence for a two-stage model of human perceptual learning
10. Amino acids in nectar enhance butterfly fecundity: A long awaited link
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2017)... -- Wake Forest Baptist Medical Center today announced Julie Ann Freischlag, ... (CEO). Freischlag joins the medical center on May 1 ... who last year announced that he would transition to ... it since 2008.   As CEO, Freischlag ... academic health system, which includes Wake Forest School of ...
(Date:2/8/2017)... 8, 2017 About Voice Recognition Biometrics Voice ... it against a stored voiceprint template. Acoustic features ... and tone are compared to distinguish between individual ... as most PCs already have a microphone and ... recognition biometrics are most likely to be deployed ...
(Date:2/7/2017)... Feb. 7, 2017   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce that ... its innovative, highly flexible and award winning eClinical solution, ... iMedNet is a proven Software-as-a-Service (SaaS) clinical ... Capture (EDC), but also delivers an entire suite of ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... , ... February 23, 2017 , ... ... (such as insulin, cortisol, CRP, adiponectin, uric acid, and/or other biomarkers or SNPs ... Insulin Assay from Salimetrics’ SalivaLab , the relationship between insulin and other ...
(Date:2/23/2017)... SAN FRANCISCO , Feb. 23, 2017 ... company, and Beyond Type 1, a not-for-profit advocacy and ... today announced a grant from Beyond Type 1 to ... type 1 and other insulin-requiring diabetes.  ... innovative stem cell-derived cell replacement therapies with a focus ...
(Date:2/22/2017)... ... February 22, 2017 , ... Park Systems , a leader in ... for all SPIE attendees and Park customers on Feb. 27, 2017 from ... San Jose Convention Center. The luncheon will feature a talk on Automated AFM ...
(Date:2/22/2017)... ... February 22, 2017 , ... ProMIS Neurosciences ... treatments for neurodegenerative diseases, today announced it has issued a scientific white paper ... one of a series of commentaries from ProMIS’s scientific team offering insight into ...
Breaking Biology Technology: