Navigation Links
Using nanomagnets to enhance medical imaging

Nanoscale magnets in the form of iron-containing molecules might be used to improve the contrast between healthy and diseased tissue in magnetic resonance imaging (MRI)—as long as the concentration of nanomagnets is carefully managed—according to a new report* by researchers at the National Institute of Standards and Technology (NIST) and collaborators. Molecular nanomagnets are a new class of MRI contrast agents that may offer significant advantages, such as versatility in design, over the compounds used today.

Contrast agents are used to highlight different tissues in the body or to help distinguish between healthy and diseased tissue. NIST is working with two universities and a hospital to design, produce and test nanomolecules that might make MRI imaging more powerful and easier to perform. The new paper resolves a debate in the literature by showing that iron-containing magnets just two nanometers wide, dissolved in water, do provide reasonable contrast in non-clinical MRI images—as long as the nanomagnet concentration is below a certain threshold. (A nanometer is one billionth of a meter.) Previous studies by other research groups had reached conflicting conclusions on the utility of molecular nanomagnets for MRI, but without accounting for concentration. NIST scientists, making novel magnetic measurements, were able to monitor the molecules' decomposition and magnetic properties as the composition was varied.

The injectable dyes currently used as MRI contrast agents are of two types. Magnetic ions, which alter the nuclear properties of hydrogen in water, offer the advantage of consistent identical design but provide low contrast. The second category encompasses particles of thousands of atoms or crystals, which alter local magnetic fields; they provide contrast variation in a larger region but have irregular designs and magnetic properties that are difficult to control. By comparison, molecular nanomagnets can be designed to have consistent properties and high contrast. In addition, they might be modified to act as "smart" materials whose contrast could be turned on only when bonded to a target molecule or cell. Toxicity is not believed to be an issue, because iron is naturally found in the body and other studies have found that these materials are non-toxic at the concentrations used in MRI.

NIST works with Florida State University to make single-molecule magnets less than five nanometers (nm) in diameter, and works with the University of Colorado at Boulder to make nanocrystals in the 10-50 nm range. The agency is pioneering methods for manipulating and measuring the magnetic properties of these compounds and is developing instrumentation for understanding how contrast agents work and how to control contrast properties. Researchers correlate the measured properties to the observed MRI response under non-clinical conditions using imagers at The Children's Hospital in Denver. The information gained is fed back into recipes for making even better nanomagnets. The work described in the new paper was supported in part by the National Science Foundation.


'"/>

Source:National Institute of Standards and Technology (NIST)


Related biology news :

1. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
2. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
3. Researchers Closer To Helping Hearing-Impaired Using Stem Cells
4. Using nanoparticles, in vivo gene therapy activates brain stem cells
5. Using computers and DNA to count bacteria
6. Using the genomic shortcut to predict bacterial behavior
7. Using natures most primitive anti-viral defense system to find new approaches to cancer research
8. Using dental X-rays to detect osteoporosis
9. Using brain scans, researchers find evidence for a two-stage model of human perceptual learning
10. Amino acids in nectar enhance butterfly fecundity: A long awaited link
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
(Date:6/9/2016)... -- Paris Police Prefecture ... to ensure the safety of people and operations in several ... tournament Teleste, an international technology group specialised in ... that its video security solution will be utilised by ... safety across the country. The system roll-out is scheduled for ...
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
Breaking Biology Technology: