Navigation Links
Use of PET can reduce, may eliminate more strenuous drug development trials with animals

iagnosis of disorders such as Alzheimer's and Parkinson's diseases, epilepsy, cardiovascular illnesses and many cancers. Researchers can gain a broader understanding of basic insights into normal physiology and disease processes to drug development and early response to anticancer and gene therapy. In addition, small animal imaging significantly reduces the preclinical evaluation time for therapeutic pharmaceuticals, possibly speeding the way for innovative drugs to patients, said Welch. Since there is no public registry of animal researchers, Welch estimates that there may be as many as 12,000 academic and private animal imaging labs in the world and that more than 200 may do small animal PET routinely.

Through small animal imaging research, Welch and his researchers gained more of an understanding about titanium anti-cancer drugs and new techniques for PET imaging with 45Ti, which they found to have excellent imaging characteristics and to be relatively inexpensive to produce. Welch and his researchers are also investigating the effect of cancer therapies on tumor function and performing cardiac studies that explore drugs that reverse the conditions of animals.

The JNM articles on small animal imaging, with numerous SNM members as authors, are listed here.

* Welch's co-author of "Preparation, Biodistribution and Small Animal PET of 45Ti-Transferrin" is Amy L. Vavere, Ph.D., Mallinckrodt Institute of Radiology at Washington University School of Medicine and the department of chemistry, Washington University, both in St. Louis, Mo.

* Authors of "Noninvasive Monitoring of Target Gene Expression by Imaging Reporter Gene Expression in Living Animals Using Improved Bicistronic Vectors" are Yanling Wang, Ph.D., and Meera Iyer, Ph.D., both with Crump Institute for Molecular Imaging and the department of molecular and medical pharmacology, David Geffen School of Medicine at UCLA, both in Los Angeles, Calif.; Alexander J. Annala, Ph.D
'"/>

Source:Society of Nuclear Medicine


Page: 1 2 3 4

Related biology news :

1. New therapy for HIV/AIDS eliminates needles and excessive toxicity
2. Stanford snake venom study shows that certain cells may eliminate poison
3. Malaria vaccine prompts victims immune system to eliminate parasite from mosquitoes
4. A much-needed shot in the arm for HIV vaccine development
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. Zebrafish may hold key to understanding human nerve cell development
7. Scientists identify new model Of NK cell development
8. Influenza vaccine uses insect cells to speed development
9. Chemists identify key gene in development of type 1 diabetes
10. Liposome finding implies electrical effect on cell development
11. Multi-purpose protein regulates new protein synthesis and immune cell development
Post Your Comments:
(Date:9/7/2008)...rules to govern commercial and research activities...ed to reflect new environmental realities and to t...osystems, according to several of the experts conv...rking the International Polar Year. , Due to cli...an is fast disappearing, creating new opportunitie...
(Date:9/5/2008)... pleased to announce the recipients of its 2009 So...eir awards at the Society,s 53rd Annual Meeting on...d Exhibitions Center in Massachusetts. The awardee...ifornia, San Francisco, will receive the Anatrace ...utions to transmembrane biology, and pioneering ne...
(Date:9/5/2008)...oundation has awarded Iowa State University and it...nt to establish the NSF Engineering Research Cente..., The award is part of the National Science Foun...ters (ERC) Program. The third-generation Engineeri...ity and industry partnerships in research and educ...
(Date:9/5/2008)...icated computer model pioneered at Princeton Unive...many governments worldwide are recommending the wr...ilability of many drugs and therapies to treat mal...using what is known as a single first-line therapy...atients. Writing in the Sept. 16 issue of the Pro...
Breaking Biology News(10 mins):Experts meet on need for new rules to govern world's fragile polar regions 2Experts meet on need for new rules to govern world's fragile polar regions 3Experts meet on need for new rules to govern world's fragile polar regions 4Experts meet on need for new rules to govern world's fragile polar regions 5Experts meet on need for new rules to govern world's fragile polar regions 6Biophysical Society names 2009 award recipients 2Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals 2Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals 3Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals 4Best way to treat malaria: Avoid using same drug for everyone, scientists say 2Best way to treat malaria: Avoid using same drug for everyone, scientists say 3Grubb 26 Ellis Healthcare REIT Acquires Epler Parke Building B in Indianapolis 15455 1Grubb 26 Ellis Healthcare REIT Acquires Epler Parke Building B in Indianapolis 15455 2Grubb 26 Ellis Healthcare REIT Acquires Epler Parke Building B in Indianapolis 15455 3MINRAD International Inc Announces Appointment of David T DiGiacinto as President and Chief Operating Officer 4253 1MINRAD International Inc Announces Appointment of David T DiGiacinto as President and Chief Operating Officer 4253 2MINRAD International Inc Announces Appointment of David T DiGiacinto as President and Chief Operating Officer 4253 3MINRAD International Inc Announces Appointment of David T DiGiacinto as President and Chief Operating Officer 4253 4Leading Epilepsy Advocates Propose Strategies to Heighten Treatment Expectations and Close Patient and Physician Communication Gaps 15451 1Leading Epilepsy Advocates Propose Strategies to Heighten Treatment Expectations and Close Patient and Physician Communication Gaps 15451 2Leading Epilepsy Advocates Propose Strategies to Heighten Treatment Expectations and Close Patient and Physician Communication Gaps 15451 3Leading Epilepsy Advocates Propose Strategies to Heighten Treatment Expectations and Close Patient and Physician Communication Gaps 15451 4Leading Epilepsy Advocates Propose Strategies to Heighten Treatment Expectations and Close Patient and Physician Communication Gaps 15451 5American Heart Association Teams Up With the Presidents Council on Physical Fitness and Sports to Promote Physical Activity and Healthy Eating 15448 1American Heart Association Teams Up With the Presidents Council on Physical Fitness and Sports to Promote Physical Activity and Healthy Eating 15448 2American Heart Association Teams Up With the Presidents Council on Physical Fitness and Sports to Promote Physical Activity and Healthy Eating 15448 3
...ecies, researchers have been able to show that a n...n in non-vertebrate organisms can also do so in at...ted by Alessandro Cellerino of the Scuola Normale ...tial utility of the compound in human aging resear...onset of aging-related diseases and improve qualit...
...ists at the University of Texas at Austin uncovere...ok similar, and it hinges on the way predators lea.... , In the Mar. 8 issue of Nature, Catherine Dars...l frog living in the Amazonian rainforest gets pro...isonous neighbor, but by looking like a frog who,s...
...ity of New Hampshire campus, David Berlinsky, assi...plastic tub. Inside, black sea bass circle slowly ...aculture research facility for the College of Life... latest research. , Black sea bass feature promine...sh are in decline and their availability is limite...
... accepted theory on the cause of sepsis -- a condi...ck and often death. Sepsis is thought to occur whe...the cells. , The Mayo researchers challenge that l...iece in the current issue of Trends in Molecular M...nal/14714914 . Their findings suggest that sepsis ...
Other Biology News:Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate 2Poison dart frog mimics gain when birds learn to stay away 2Poison dart frog mimics gain when birds learn to stay away 3Uncovering sex-change secrets of black sea bass 2Mayo Clinic researchers challenge sepsis theory 2Mayo Clinic researchers challenge sepsis theory 3
(Date:9/5/2008)...pt. 5 /- Campbell Alliance, the leadi...pharmaceutical and biotech,industry, today announc...ct,two speaking engagements at the Center for Busi...lving the Pharma Sales Model, to be held September...lphia, PA., An award-winning sales professional b...
(Date:9/4/2008)...., Sept. 4 /- MedQuist Inc....f directors has elected John,F. Jastrem, Colin J. ...tive,September 4, 2008. Prior to the election of t...the size of the board from seven to 10 members., ... Aquilina, "We are,pleased to have this opportunit...
(Date:9/4/2008)..., Sept. 4 /- BioForm Medica...cial results for the fourth,quarter and full fisca...illion for the quarter ended June 30, 2008 as comp...0, 2007, an increase of $1.3 million or 8.4%.,The ...une 30, 2008 as,compared to a net loss of $4.9 mil...
(Date:9/4/2008)...lights: - Revenues of $88.4 million, up 14% from t...re of $0.28, an increase of, 47% over last year,s...n, (Year-to-date operating cash flow of $62 millio...venues and earnings guidance, COLUMBIA, Md., Sept...orporation (Nasdaq: MATK ) today announced its fi...
Breaking Biology Technology:Campbell Alliance Sales Practice to Present at CBI's Leadership Summit on Evolving the Pharma Sales Model 2Campbell Alliance Sales Practice to Present at CBI's Leadership Summit on Evolving the Pharma Sales Model 3Campbell Alliance Sales Practice to Present at CBI's Leadership Summit on Evolving the Pharma Sales Model 4MedQuist Announces Additions to Board of Directors 2MedQuist Announces Additions to Board of Directors 3BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 2BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 3BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 4BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 5BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 6BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 7BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 8BioForm Reports Financial Results for the Fourth Quarter and Full Fiscal Year Ended June 30, 2008 9Martek Announces Third Quarter 2008 Financial Results 2Martek Announces Third Quarter 2008 Financial Results 3Martek Announces Third Quarter 2008 Financial Results 4Martek Announces Third Quarter 2008 Financial Results 5Martek Announces Third Quarter 2008 Financial Results 6Martek Announces Third Quarter 2008 Financial Results 7Martek Announces Third Quarter 2008 Financial Results 8Martek Announces Third Quarter 2008 Financial Results 9Martek Announces Third Quarter 2008 Financial Results 10
... Perfect gDNA Blood Mini Kit , by Varyin... , , , Laura Pollock and Jennifer Ha...orado, , , , , , Introduc...d Mini Kit protocol recommends , an eluti...dard , application. In some instances, th...
... , , , Efficiency of the standard prot...anded DNA may be improved through the use of PLG. ...one of the standard procedures: , , ...ating bacteria (57 , hours, 50 ml c... with 300 l M13 phage stock (1 x 1011...
... , E-mail us your application notes for inc...ontribution published will be acknowledged with a ... , , , , , , Protocols fo...am negative , , <A , ...p?id=575">Actinobacillus , pleuropnomon...
..., Genetic reporter systems have developed into ...y promoter and enhancer sequences as well as trans...ent under investigation (promoter, enhancer) is cl...n expression vector, which is subsequently , ...eporter indirectly provides , information o...
Other Biology Technology:Higher gDNA Concentrations with the Perfect gDNA Blood Mini Kit , by Varying the Final Elution Volume 2Higher gDNA Concentrations with the Perfect gDNA Blood Mini Kit , by Varying the Final Elution Volume 3Higher gDNA Concentrations with the Perfect gDNA Blood Mini Kit , by Varying the Final Elution Volume 4Higher gDNA Concentrations with the Perfect gDNA Blood Mini Kit , by Varying the Final Elution Volume 5Higher gDNA Concentrations with the Perfect gDNA Blood Mini Kit , by Varying the Final Elution Volume 6Higher gDNA Concentrations with the Perfect gDNA Blood Mini Kit , by Varying the Final Elution Volume 7M13/Phagemid DNA Extraction Protocol 2Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 2Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 3Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 4Eppendorf Electroporation Application Notes Your participation , is highly welcome !!! 5Genetic Reporter Systems 2Genetic Reporter Systems 3Genetic Reporter Systems 4
... Phosphorylated Anti-GluR1 Glutamate is the main ... years it had been considered to act only on the l...d kainate receptors that are involved in the fast ...ate has been shown to regulate enzymes producing s...
Anti-ADP-Ribosylation Factor 1, clone 3F1 Immunogen: Synthetic peptide corresponding to the C-terminal amino acid sequence of human ARF1. Available Date: 38495
TNF-Related Apoptosis Inducing Ligand-Receptor-1
Pim-1 (12H8)
Biology Products: