Navigation Links
Use of Antibiotics for Acne May Increase Risk of Common Illness

Novel use of genetic testing methods helped public health officials control and limit the further spread of four outbreaks of foodborne hepatitis A virus in 2003 related to the consumption of green onions, according to a detailed analysis published in the October 15 issue of The Journal of Infectious Diseases, now available online.

The authors of the study, Joseph J. Amon, PhD, MSPH, and colleagues at the Centers for Disease Control and Prevention (CDC), explained that these molecular epidemiologic methods had not previously been used in an ongoing investigation of a hepatitis A virus outbreak. The methods, involving genetic sequencing analysis of virus found in blood samples from infected individuals, have greatly improved understanding of outbreaks of other foodborne pathogens, but are time-consuming and not widely available.

In September 2003, Tennessee, North Carolina, and Georgia reported a total of 422 cases of foodborne hepatitis A virus infection to CDC. Preliminary investigations suggested clustering of reported cases among patrons of three unrelated restaurants. Investigators identified green onions as the likely culprit in the outbreak by interviewing infected and uninfected restaurant patrons. In addition to these standard techniques, the researchers also compared viral RNA sequences from case patients and individuals concurrently ill with hepatitis A virus infection in non-outbreak settings in the United States and Mexico.

Viral RNA sequences from patients in the three states, plus patients involved in a subsequent outbreak in Pennsylvania in October 2003 (the latter recently described in the Sept. 1 issue of the New England Journal of Medicine), were slightly different from each other. The viral sequence from each outbreak, however, was identical to one or more sequences isolated from northern Mexican residents infected with hepatitis A virus. The researchers concluded that the sources of the green onions served in restaurants in Tennessee and Georgia were three farms in northern Mexico.

Dr. Amon and colleagues credited the viral sequencing techniques with helping them to identify the relationships between the outbreaks in four separate locations, and to define the scope of the outbreaks quickly. The sequencing allowed them to determine if cases reported in other states were related to the four original outbreaks and provided reassurance that a larger outbreak was not occurring. The molecular epidemiologic methods also enabled public health officials to respond quickly to the later Pennsylvania outbreak. As a result, consumers were warned of the potential risk, and entry of green onions from four Mexican farms into the state was banned.

"This research highlights the role of viral sequence analysis in improving our overall understanding of the roughly 50 percent of hepatitis A cases in the U.S. that are from an unknown source," Dr. Amon said. "Just as the E. coli-contaminated beef outbreaks in the early 1990s prompted changes in epidemiological surveillance that have increased our knowledge of foodborne bacteria, the 2003 hepatitis A outbreaks demonstrated the potential for integrated molecular surveillance to provide a better understanding of the epidemiology of hepatitis A and facilitate rapid responses to outbreaks."


'"/>

Source:


Related biology news :

1. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
2. Increased risk of osteoporosis associated with gene that one in five people have
3. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
4. Morphine for Chest Pain Increases Death Risk
5. Sea Ice May Be on Increase in the Antarctic
6. Increased sensitivity to nerve signals keeps diabetes at bay
7. Increase in carbon dioxide emissions accelerating
8. Increase in drug development for killer diseases is not enough
9. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
10. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
11. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... 7, 2017   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that the ... innovative, highly flexible and award winning eClinical solution, is ... iMedNet is a proven Software-as-a-Service (SaaS) clinical research ... (EDC), but also delivers an entire suite of eClinical ...
(Date:2/7/2017)... 7, 2017 Ipsidy Inc. ( ... [OTC: IDGS], ("Ipsidy" or the "Company") a provider of ... services, is pleased to announce the following changes as ... Effective January 31, 2017, Philip D. Beck ... and President.  An experienced payment industry professional and public ...
(Date:2/3/2017)... -- Texas Biomedical Research Institute announced that its Board of Trustees ... the Institute,s new President and CEO. Dr. Schlesinger will take ... is currently the Chair of the Department of Microbial Infection ... Biology at Ohio State University. "We are delighted ... of Texas Biomed," said Dr. James O. Rubin , ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... ... February 21, 2017 , ... During ... connected digital health applications, announced a partnership with Redox, a leader in cloud-based ... to many clinical systems while keeping data secure in the cloud. , The ...
(Date:2/21/2017)... ... 2017 , ... The medical potential of stem cells is both extensive and ... due to their differentiating characteristics. Stem cells are unique as the have the potential ... to become tissue or organic-specific cells with special functions. , Stem cell therapy ...
(Date:2/21/2017)... and VANCOUVER, British Columbia , Feb. ... ) today announced that apatorsen results from two randomized Phase ... Clinical Oncology (ASCO) 2017 Genitourinary Cancers Symposium, held February 16 ... . Clinical data from trials in bladder and prostate cancers ... in combination with standard-of-care treatments. ...
(Date:2/21/2017)... , Feb. 21, 2017   Invitae Corporation ... information companies, today announced that members of the company,s ... 37th Annual Health Care Conference on Monday, March 6, ... Pacific in Boston, Massachusetts . ... may be accessed by visiting the investors section of ...
Breaking Biology Technology: