Navigation Links
Unusual mechanism keeps repair protein accurate

Cancer researchers have discovered that a recently identified protein critical for repairing damaged genes uses an unusual mechanism to keep its repairs accurate.

The protein, called DNA polymerase lambda, is one of a group of proteins known as DNA polymerases that are vital for accurately making and repairing DNA.

But while other DNA-repair proteins insure their accuracy with the help of so-called proof-reading regions or accessory molecules, this protein maintains its accuracy using an otherwise ordinary-looking portion of its molecular structure.

The study was led by Zucai Suo, assistant professor of biochemistry and a researcher with the Ohio State University Comprehensive Cancer Center ?Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. The research, published in the July 14 issue of The Journal of Biological Chemistry, provides new insights into how cells repair damaged DNA.

"DNA is constantly attacked and damaged by a variety of agents," Suo says. "The body must properly repair that damage, or it can lead to cell death or to cancer, birth defects and other diseases.

"There are six families of DNA polymerases," Suo says, "and this is the first polymerase to use this mechanism to maintain its accuracy when making new DNA. It is both surprising and unprecedented."

The repair protein itself was first discovered by scientists studying DNA sequence data produced by the Human Genome Project. Suo and his colleagues then became interested in learning how the repair protein worked.

The protein has four distinct regions, or domains. Three of the regions had molecular structures that strongly suggest the task they performed.

For example, regions three and four closely resemble a well-known repair protein called DNA polymerase beta. In fact, it was this similarity that tipped off scientists that the new protein was probably involved in DNA repair.

Region one als
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Unusual antibiotics show promise against deadly superbugs
2. A new mechanism of regulating RNA degradation
3. Plants, animals share molecular growth mechanisms
4. PET/MRI scans may help unravel mechanisms of prenatal drug damage
5. Researchers discover molecular mechanism that desensitizes us to cold
6. Chemists identify immune system mechanism for methamphetamine binges
7. Key mechanism in genetic inheritance during cell division identified
8. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
9. Mouse gene shows new mechanism behind cardiac infarction in man
10. UCSD research reveals mechanism involved with type of fatal epilepsy
11. Ancient immune defense mechanism is no match for HIV-1
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Unusual mechanism keeps repair protein accurate

(Date:3/24/2015)... Mar. 24, 2015 Research and Markets ... "Global Iris Recognition Market 2015-2019" report to ... Iris Recognition market to grow at a CAGR of ... report covers the present scenario and the growth prospects ... 2015-2019. To calculate the market size, the report considers ...
(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... CA---- Researchers at the Salk Institute for Biological Studies have, ... and turned them into induced pluripotent stem cells (iPSCs), a ... other cell or tissue in the body. Mouse iPSCs ... at Kyoto University in Japan, and human iPSCs soon followed----feats ...
... and mobile internet to navigate strange cities in search of ... and upload their videos directly to social media sites while ... can save a well-loved device from dying when its battery ... ailment that plagues solar power plants and wind farms ...
... using bubble nets, scientists at the University of Southampton, ... Services, have developed a new kind of radar that ... twin inverted pulse radar (TWIPR) is able to distinguish ... that may be used in explosive or espionage devices, ...
Cached Biology News:Induced pluripotent stem cells reveal differences between humans and great apes 2Induced pluripotent stem cells reveal differences between humans and great apes 3Futuristic copper foam batteries get more bang for the buck 2Futuristic copper foam batteries get more bang for the buck 3Dolphins inspire new radar system to detect hidden surveillance and explosive devices 2Dolphins inspire new radar system to detect hidden surveillance and explosive devices 3
(Date:3/31/2015)... Pa. , March 31, 2015   ... by integrating Mapi,s Medical Affairs and global Risk ... from a previously announced acquisition . ... operations are conducted by a global team that ... that have decades of experience in navigating complex ...
(Date:3/31/2015)... Angeles, CA (PRWEB) March 31, 2015 ... and Professors from the top U.S and International Medical ... share their latest research on the application of stem ... diseases. The symposium is organized and funded by the ... independent nonprofit that has been convening intimate meetings of ...
(Date:3/30/2015)... 2015 With recent advancements in residential ... government, major companies are getting into the Solar Energy ... mandates for renewable energy production, many homeowners are looking ... Power is a new solar distribution company in California ... allow qualifying homeowners to enjoy the benefits of solar ...
(Date:3/30/2015)... March 30, 2015  NuGene International, Inc. ("NuGene") ... NuGene BioPharma, Inc. has added another internationally recognized ... Guan is an internationally recognized researcher in bio-inspired ... education at Peking University, China ... the University of North Carolina, Chapel Hill. Following ...
Breaking Biology Technology:Mapi expands Pharmacovigilance and Risk Management capabilities 2Mapi expands Pharmacovigilance and Risk Management capabilities 3Sight Restoration Through Stem Cell Therapy - Subject of June Symposium of Experts 2Solara Power Announces Residential Solar Power with No Up-Front Fees 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 3
... - In the wake of shareholder lawsuits alleging ... of Merge Technologies, Inc. has accepted the ... ,Bill Mortimore, who founded the company and served as ... been appointed as the company's interim CEO. Mike Dunham, ...
... Hartford-based api Software, Inc . has entered into agreements ... and health systems, for whom it may become a key ... system so that parts of the bundle play a role ... era of severe nursing shortages. , ,Shift bidding, for ...
... for new ways to increase sales tax revenues. Some ... to develop open lands and renovate old structures. Others ... reduced fees to relocate a business within their municipalities. ... large municipalities in Chicago giving away tax incentives and ...
Cached Biology Technology:Merge president steps down in wake of shareholder suits 2Merge president steps down in wake of shareholder suits 3Medical software may be a retention tool 2Electronic signs for municipalities: Las Vegas or lost revenues? 2Electronic signs for municipalities: Las Vegas or lost revenues? 3Electronic signs for municipalities: Las Vegas or lost revenues? 4
... role in the regulation of signaling pathways ... variants have been reported that affect both ... pathways. With Apoptosis and Cell Death ... profiling and at the same time detect ...
Mouse monoclonal antibody raised against a full length recombinant CSNK2A2. NCBI Entrez Gene ID = CSNK2A2...
... manufactured for DNA purification from agarose gels ... light. The Purification of DNA from an ... work. The conventional method of visualizing DNA ... light damages DNA and significantly decreases cloning ...
... partial recombinant MAK. Immunogen: ... recombinant protein with GST tag. ... BC039825 Protein Accession Number: ... GeneID: 4117 ...
Biology Products: